DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB20

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_191092.1	Gene:	ABCB20 / 824698	AraportID:	AT3G55320	Length:	1408	Species:	Arabidopsis thaliana

Alignment Length:	1422	Identity:	408/1422 - (28%)
Similarity:	694/1422 - (48%)	Gaps:	191/1422 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MTETREDVPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVF 67
            :.|..|::...|..|..|||             |.:::||.....:|:::::.|.|||....
plant    51 LAEADEEMDDQDELEPPPAA-------------VPFSQLFACADRFDWVLMIVGSVAAAAHG--- 99

  Fly    68 PIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLN 132
             .|::||....|                        ||:...::..:..:.|.:. .|..|:.|:
plant   100 -TALIVYLHYFA------------------------KIVDVLAFSNDSSQQRSEH-QFDRLVQLS 138

  Fly   133 TLLMLFSGVYYVDAFNRLAL------KLTVRMRREFFKATLRQEIGWHD-MAKDQNFAVRITDNM 190
            ..::..:|..::..:..::.      :.|..:|.::.:..|.|::.:.| ...:.:...::..::
plant   139 LTIVYIAGGVFISGWIEVSCWILTGERQTAVIRSKYVQVLLNQDMSFFDTYGNNGDIVSQVLSDV 203

  Fly   191 EKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQ 255
            ..|:|.::|.:|:|:..|...|..:|:.|:..|::||..:...|..:........:..:|....|
plant   204 LLIQSALSEKVGNYIHNMATFISGLVIGFVNCWEIALITLATGPFIVAAGGISNIFLHRLAENIQ 268

  Fly   256 SSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFIT 320
            .:|..|:.:.|:.|..|||:.||..|......|.:.|:..|:.|.......||.......:...:
plant   269 DAYAEAAGIAEQAISYIRTLYAFTNETLAKYSYATSLQATLRYGILISLVQGLGLGFTYGLAICS 333

  Fly   321 GAGSFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASA 385
            .|...|.|...:...|     .:..|...|:..:::||:  ..||.:..   ..:|...|.:|..
plant   334 CALQLWIGRFFVHNGR-----ANGGEIIAALFAVILSGL--GLNQAATN---FYSFDQGRIAAYR 388

  Fly   386 ILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGP 450
            :.::|.|:|.:  .::.|.:| ..::|.:|||:|:|.|.:|.::.:|.|..:.|...:.|||||.
plant   389 LFEMITRSSSV--ANQEGAVL-ASVQGNIEFRNVYFSYLSRPEIPILSGFYLTVPAKKAVALVGR 450

  Fly   451 SGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKP 515
            :|.|||:.|.|::|||||..|:||||||:::...::||||.|.:|.|||.|...||.|||.:|:
plant   451 NGSGKSSIIPLMERFYDPTLGEVLLDGENIKNLKLEWLRSQIGLVTQEPALLSLSIRENIAYGR- 514

  Fly   516 EATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEAT 580
            :||..::|:|||.|:||.||.:|.|||:|.:...|:.::..|:.:::||||::..|.||||||.|
plant   515 DATLDQIEEAAKNAHAHTFISSLEKGYETQVGRAGLAMTEEQKIKLSIARAVLLNPTILLLDEVT 579

  Fly   581 SALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYH 645
            ..||:.:|::||.|||....||:|::::.|||.|::|..|..:|.|:.||.|||:||:.|.|.|.
plant   580 GGLDFEAERIVQEALDLLMLGRSTIIIARRLSLIKNADYIAVMEEGQLVEMGTHDELINLGGLYA 644

  Fly   646 KM------------VTVHSYDDSA-------------------------------------EELL 661
            ::            :.|.:|.:||                                     :||.
plant   645 ELLKCEEATKLPRRMPVRNYKESAVFEVERDSSAGCGVQEPSSPKMIKSPSLQRGSGVFRPQELC 709

  Fly   662 NELEEVAEIK--------ERKMSYEV---EPYQLGTRNSIVSLEKNAEFQMK------------- 702
            .:.||..:..        |..||.:.   ||          ::::...|:|:
plant   710 FDTEESPKAHSPASEKTGEDGMSLDCADKEP----------TIKRQDSFEMRLPHLPKVDVQCPQ 764

  Fly   703 -NLNGLA-------------------NITMNQEIDDPRVPSANFIS----------TFFRILGWA 737
             ..||..                   :.|.::.:..|....||..:          :|:|:...:
plant   765 QKSNGSEPESPVSPLLTSDPKNERSHSQTFSRPLSSPDDTKANGKASKDAQHKESPSFWRLAQLS 829

  Fly   738 RPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVC 802
            .|||.:.::|::.|.::|...|:.:.|:|.:.....|.....:.|:.....:|...:||...|..
plant   830 FPEWLYAVLGSLGAAIFGSFNPLLAYVIALVVTEYYKSKGGHLREEVDKWCLIIACMGIVTVVAN 894

  Fly   803 YIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSN 867
            ::|.|:|.:.|..:|.|:|...|..::..|:||||.:|||...||.||:.||..|:.|....||.
plant   895 FLQHFYFGIMGEKMTERVRRMMFSAMLRNEVGWFDDEENSPDTLSMRLANDATFVRAAFSNRLSI 959

  Fly   868 IIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATET 932
            .||.....|.::.|.....|.|||:.|:|.|.:..|.:.:..:....:...:|:..:.|.:..:.
plant   960 FIQDSFAVIVALLIGLLLGWRLALVALATLPILTLSAIAQKLWLAGFSKGIQEMHRKASLVLEDA 1024

  Fly   933 ITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCA 997
            :..|.||.......:::::|..:::|...|........|......:.|:|...|:.|........
plant  1025 VRNIYTVVAFCAGNKVMELYRMQLQRILRQSYLHGMAIGFAFGFSQFLLFACNALLLWCTALSVN 1089

  Fly   998 DGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNG 1062
            .|.:|..|.:.......:..|.|.:.....|.......|...::||:||.|.|:..::
plant  1090 RGYMKLSTAITEYMVFSFATFALVEPFGLAPYILKRRKSLISVFEIVDRVPTIEPDDN------- 1147

  Fly  1063 NGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRY 1127
              :|.|...|...:..:.::|.||:||.|.||.||:|.|:.|||||:||.|||||||.:.|:.||
plant  1148 --SALKPPNVYGSIELKNVDFCYPTRPEILVLSNFSLKISGGQTVAVVGVSGSGKSTIISLVERY 1210

  Fly  1128 YDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYG-DTSRQVPMQQIIEAA 1191
            |||..|::|:|...:.. .:|:.||..:|:|.|||.:|..:|.:||.|. ..:.:..|:   |||
plant  1211 YDPVAGQVLLDGRDLKL-YNLRWLRSHMGLVQQEPIIFSTTIRENIIYARHNASEAEMK---EAA 1271

  Fly  1192 KMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVV 1256
            ::||||.||.|||..|||.:|.:|.:|:.||||||||||.:::|..|:|:|||:|:::.:|.|||
plant  1272 RIANAHHFISSLPHGYDTHIGMRGVELTPGQKQRIAIARVVLKNAPIILIDEASSSIESESSRVV 1336

  Fly  1257 QQALDSACSG-RTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKL 1312
            |:|||:...| :|.|:||||.:.:::.:.|.|:..|:|||:|:|..|.||||:|.:|
plant  1337 QEALDTLIMGNKTTILIAHRAAMMRHVDNIVVLNGGRIVEEGTHDSLAAKNGLYVRL 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	388/1341 (29%)
		ABC_membrane	<147..333	CDD:279056	39/192 (20%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	108/246 (44%)
		ABC_membrane	749..1019	CDD:279056	65/269 (24%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	114/239 (48%)
ABCB20	NP_191092.1	MdlB	86..651	CDD:224055	178/607 (29%)
		ABC_membrane	93..366	CDD:279056	56/306 (18%)
		P-loop_NTPase	414..648	CDD:304359	108/234 (46%)
		MdlB	821..1400	CDD:224055	198/586 (34%)
		ABC_membrane	841..1112	CDD:279056	66/270 (24%)
		P-loop_NTPase	1159..1395	CDD:304359	114/239 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780