DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB19

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_189528.1	Gene:	ABCB19 / 822519	AraportID:	AT3G28860	Length:	1252	Species:	Arabidopsis thaliana

Alignment Length:	1337	Identity:	460/1337 - (34%)
Similarity:	736/1337 - (55%)	Gaps:	110/1337 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MTETREDVPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVF 67
            |:||.    ..|| :..||..:||  ||::.|   :.:||.:...:|||::..|.:.|.:.....
plant     1 MSETN----TTDA-KTVPAEAEKK--KEQSLP---FFKLFSFADKFDYLLMFVGSLGAIVHGSSM 55

  Fly    68 PIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLN 132
            |:..:::.::|.                     |.||  ......:.:.|:.:.|:.|..|
plant    56 PVFFLLFGQMVN---------------------GFGK--NQMDLHQMVHEVSRYSLYFVYL---- 93

  Fly   133 TLLMLFSGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDM-AKDQNFAVRITDNMEKIRSG 196
            .|::.||....:..:.....:....:|:::.:|.|:|::|:.|. |:..:....::.:...::..
plant    94 GLVVCFSSYAEIACWMYSGERQVAALRKKYLEAVLKQDVGFFDTDARTGDIVFSVSTDTLLVQDA 158

  Fly   197 IAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRA 261
            |:|.:|:::..:...:..:|:.|:..|||||..|..||.........|:....:|.:.:.||..|
plant   159 ISEKVGNFIHYLSTFLAGLVVGFVSAWKLALLSVAVIPGIAFAGGLYAYTLTGITSKSRESYANA 223

  Fly   262 SSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFW 326
            ..:.|:.|..:|||.::.||......|...::..||.|...|...||.......:..::.|..||
plant   224 GVIAEQAIAQVRTVYSYVGESKALNAYSDAIQYTLKLGYKAGMAKGLGLGCTYGIACMSWALVFW 288

  Fly   327 YGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVID 391
            |..   ::.|:..  .|..:...|:...::.|:     .:.::...|..|:..:.:...::::|:
plant   289 YAG---VFIRNGQ--TDGGKAFTAIFSAIVGGM-----SLGQSFSNLGAFSKGKAAGYKLMEIIN 343

  Fly   392 R--TSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCG 454
            :  |.:.|||.  ||.|:. :.|.:||:||.|.||:|.||::.|..|:....|:|||:||.||.|
plant   344 QRPTIIQDPLD--GKCLDQ-VHGNIEFKDVTFSYPSRPDVMIFRNFNIFFPSGKTVAVVGGSGSG 405

  Fly   455 KSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQ 519
            |||.:.|::|||||..||:||||.:::...:|:||..|.:|.|||.||..:|.|||.:|||:||.
plant   406 KSTVVSLIERFYDPNSGQILLDGVEIKTLQLKFLREQIGLVNQEPALFATTILENILYGKPDATM 470

  Fly   520 KEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALD 584
            .|||.||.|||||.||..|.|||||.:.|:||||||||:||||||||:::.||||||||||||||
plant   471 VEVEAAASAANAHSFITLLPKGYDTQVGERGVQLSGGQKQRIAIARAMLKDPKILLLDEATSALD 535

  Fly   585 YHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVT 649
            ..||.:||.|||:...||||:||:|||..||:...|..|:.|:.||.||||||:...|.|..::.
plant   536 ASSESIVQEALDRVMVGRTTVVVAHRLCTIRNVDSIAVIQQGQVVETGTHEELIAKSGAYASLIR 600

  Fly   650 VHSYDDSAEELLNELE----EVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANI 710
            .       :|::...:    .....:..::|:.:....|..|:.  ||...:.......:|...:
plant   601 F-------QEMVGTRDFSNPSTRRTRSTRLSHSLSTKSLSLRSG--SLRNLSYSYSTGADGRIEM 656

  Fly   711 TMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAEL------- 768
            ..|.|.|.......|:   |:|:|....|||.:.|:||:.:.|.|...|.|::|::.:
plant   657 ISNAETDRKTRAPENY---FYRLLKLNSPEWPYSIMGAVGSILSGFIGPTFAIVMSNMIEVFYYT 718

  Fly   769 -YGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQE 832
             |.|:.:.|.|.|        .|.:..|:.|.....||.:||::.|..||||:|......|:..|
plant   719 DYDSMERKTKEYV--------FIYIGAGLYAVGAYLIQHYFFSIMGENLTTRVRRMMLSAILRNE 775

  Fly   833 MGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTS 897
            :||||..|::...::|||:.|||.|:.||...:|.|:|..|:.:.|..:||...|.::|:.|.|.
plant   776 VGWFDEDEHNSSLIAARLATDAADVKSAIAERISVILQNMTSLLTSFIVAFIVEWRVSLLILGTF 840

  Fly   898 PFMVASIVFEARFGEKSALK-----EKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVE 957
            |.:|.     |.|.::.:||     ..:...:||.||.|.::.|||||....:.:::.::..|:.
plant   841 PLLVL-----ANFAQQLSLKGFAGDTAKAHAKTSMIAGEGVSNIRTVAAFNAQSKILSLFCHELR 900

  Fly   958 RYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQ 1022
            ..:.:.|.|.:..|.:..|.:..::...|:.|.||.|:.:.|...|..::|:...::.....:|:
plant   901 VPQKRSLYRSQTSGFLFGLSQLALYGSEALILWYGAHLVSKGVSTFSKVIKVFVVLVITANSVAE 965

  Fly  1023 SLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPS 1087
            :::..|.......:...::.::||:.:|...::         .|.....::..:.:|.::|:|||
plant   966 TVSLAPEIIRGGEAVGSVFSVLDRQTRIDPDDA---------DADPVETIRGDIEFRHVDFAYPS 1021

  Fly  1088 RPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLR 1152
            ||.:.|.::|||.|..|.:.|||||||||||:.:.::.|:|||..||::||.:.|.. ::||:||
plant  1022 RPDVMVFRDFNLRIRAGHSQALVGASGSGKSSVIAMIERFYDPLAGKVMIDGKDIRR-LNLKSLR 1085

  Fly  1153 RRLGIVSQEPSLFEKSIADNIGYG-DTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGT 1216
            .::|:|.|||:||..:|.|||.|| |.:.:   .::|:||:.||||.||..||..|.|.:|.:|.
plant  1086 LKIGLVQQEPALFAATIFDNIAYGKDGATE---SEVIDAARAANAHGFISGLPEGYKTPVGERGV 1147

  Fly  1217 QLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQN 1281
            |||||||||||||||:::||.:|||||||||||.:||.|:|:||:....|||.:|:|||||||:.
plant  1148 QLSGGQKQRIAIARAVLKNPTVLLLDEATSALDAESECVLQEALERLMRGRTTVVVAHRLSTIRG 1212

  Fly  1282 ANVICVIQAGKIVEQGSHSQLLAK-NGIYSKLYRCQT 1317
            .:.|.|||.|:||||||||:|::: .|.||:|.:.||
plant  1213 VDCIGVIQDGRIVEQGSHSELVSRPEGAYSRLLQLQT 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	435/1251 (35%)
		ABC_membrane	<147..333	CDD:279056	43/186 (23%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	135/234 (58%)
		ABC_membrane	749..1019	CDD:279056	79/282 (28%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	129/241 (54%)
ABCB19	NP_189528.1	PTZ00265	17..1247	CDD:240339	451/1312 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	180	1.000	Domainoid score	I1042
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.790