DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB16

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_189477.4	Gene:	ABCB16 / 822465	AraportID:	AT3G28360	Length:	1228	Species:	Arabidopsis thaliana

Alignment Length:	1325	Identity:	438/1325 - (33%)
Similarity:	706/1325 - (53%)	Gaps:	149/1325 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFG 101
            |...:|.:..|.|::::..|.:.|.....:.||...:.:.|                   |:.||
plant     6 SMRSIFMHADGVDWMLMGLGLIGAVGDGFITPILFFITAML-------------------LNDFG 51

  Fly   102 GGKILTNASYEEN--MQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKLTVRMRREFFK 164
                  :.|:.:.  ||.:.|::::...:...:.::....|..:.....|.|.|    ||..:.:
plant    52 ------SFSFNDETFMQPISKNALAMLYVACASWVICFLEGYCWTRTGERQAAK----MRERYLR 106

  Fly   165 ATLRQEIGWHDM--AKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLAL 227
            |.|||::|:.|:  ....:....::.:...|:..::|.|.:.:......:.|.::.|:..|:|.:
plant   107 AVLRQDVGYFDLHVTSTSDIITSVSSDSLVIQDFLSEKLPNILMNASAFVGSYIVGFMLLWRLTI 171

  Fly   228 A-----IVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLR 287
            .     |:..|| .|:...|:.....|:    :..|..|.|:.|:.|.::|||.||..|:....:
plant   172 VGFPFIILLLIP-GLMYGRALIGISRKI----REEYNEAGSIAEQAISSVRTVYAFVSEKKMIEK 231

  Fly   288 YDSLLKPALKAGKWKGAFSGL---SDTVMKAML-FITGAGSFWYGANLILYYRDPSIPIDEREYT 348
            :...|:.::|.|..:|...|:   |:.::.|:. |:|     |||:.:::.|          .|.
plant   232 FSDALQGSVKLGLRQGLAKGIAIGSNGIVYAIWGFLT-----WYGSRMVMNY----------GYK 281

  Fly   349 PAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGA 413
            ...|..|...:......:.:....|:.|:.|..:...|..:|.|...||..:..|.||. .::|.
plant   282 GGTVSTVTVCVTFGGTALGQALSNLKYFSEAFVAGERIQKMIKRVPDIDSDNLNGHILE-TIRGE 345

  Fly   414 VEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGE 478
            |||.:|..:||:|.:.::...|.:.:..|:||||||.||.||||.|.||||||||..|.:|:|..
plant   346 VEFNNVKCKYPSRPETLIFDDLCLKIPSGKTVALVGGSGSGKSTVISLLQRFYDPNEGDILIDSV 410

  Fly   479 DVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYD 543
            .:....:|||||.:.:|.|||.||..||.|||..||.:|:..||.:||||:|||:||.....||.
plant   411 SINNMQVKWLRSQMGMVSQEPSLFATSIKENILFGKEDASFDEVVEAAKASNAHNFISQFPHGYQ 475

  Fly   544 TDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVS 608
            |.:.|:||.:||||:||||||||||:.|.||||||||||||..||::||.|||.|..||||:|::
plant   476 TQVGERGVHMSGGQKQRIAIARALIKSPIILLLDEATSALDLESERVVQEALDNASVGRTTIVIA 540

  Fly   609 HRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAE---- 669
            ||||.||:|..|..:.||..||.|:|::||:::|.|..:|.:       :::.|  ||..:
plant   541 HRLSTIRNADIICVLHNGCIVETGSHDKLMEIDGKYTSLVRL-------QQMKN--EESCDNTSV 596

  Fly   670 -IKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDD-------PRVPSANF 726
             :||.::|               ||..:.::..::|....:.::...:.|       |.|||
plant   597 GVKEGRVS---------------SLRNDLDYNPRDLAHSMSSSIVTNLSDSIPQDKKPLVPS--- 643

  Fly   727 ISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAIIS 791
               |.|::...||||...:.|.:.|.|.|...|::: ..:.|..|:...|:.|.::::..:.::
plant   644 ---FKRLMAMNRPEWKHALCGCLSASLGGAVQPIYA-YSSGLMISVFFLTNHEQIKENTRIYVL- 703

  Fly   792 LVIGIAAGVVCYIQTFF--------FNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSA 848
            |..|:|      :.|||        |:..|.:||.|:|.:....|:..|:.|||.:|||.||:.:
plant   704 LFFGLA------LFTFFTSISQQYSFSYMGEYLTKRIREQMLSKILTFEVNWFDEEENSSGAICS 762

  Fly   849 RLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEK 913
            ||:.||..|:..:|..:|.::|..:..:.:..|....:|...::.:|..|.::.....:....:.
plant   763 RLAKDANVVRSLVGERMSLLVQTISTVMVACTIGLVIAWRFTIVMISVQPVIIVCYYIQRVLLKN 827

  Fly   914 SALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKW-RGLVNSLG 977
            .:.|.....:|:|::|.|.::.|||:.....:|.::|:.::..|..|.: .:|..| .|::....
plant   828 MSKKAIIAQDESSKLAAEAVSNIRTITTFSSQERIMKLLERVQEGPRRE-SARQSWLAGIMLGTT 891

  Fly   978 KSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLF-----ILAQSLAFTPAFNAALLSA 1037
            :||:....|:...|||.:.||||:..:...:     |:.:|     .:|::...|........|.
plant   892 QSLITCTSALNFWYGGKLIADGKMVSKAFFE-----LFLIFKTTGRAIAEAGTMTTDLAKGSNSV 951

  Fly  1038 NRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDIN 1102
            :.::.::||:..|: ||        |...|....::..:::..::|:||:||::.:..||:::|:
plant   952 DSVFTVLDRRTTIE-PE--------NPDGYILEKIKGQITFLNVDFAYPTRPNMVIFNNFSIEIH 1007

  Fly  1103 QGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESI--HHDMDLKTLRRRLGIVSQEPSLF 1165
            :|::.|:||.|.|||||.:.|:.|:|||.:|.:.||...|  :|   |::||:.:.:|||||:||
plant  1008 EGKSTAIVGPSRSGKSTVIGLIERFYDPLQGIVKIDGRDIRSYH---LRSLRQHMSLVSQEPTLF 1069

  Fly  1166 EKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIAR 1230
            ..:|.:||.||..|.::...:||||.|.|||||||.||...|||..|.:|.||||||||||||||
plant  1070 AGTIRENIMYGRASNKIDESEIIEAGKTANAHEFITSLSDGYDTYCGDRGVQLSGGQKQRIAIAR 1134

  Fly  1231 AMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVE 1295
            .:::||.||||||||||||.|||||||.||:....|:|.:|||||||||||.:.|.|:..||:||
plant  1135 TILKNPSILLLDEATSALDSQSERVVQDALEHVMVGKTSVVIAHRLSTIQNCDTIAVLDKGKVVE 1199

  Fly  1296 QGSHSQLLAK--NGIYSKLYRCQTK 1318
            .|:|:.||||  .|.|..|...|.|
plant  1200 SGTHASLLAKGPTGSYFSLVSLQRK 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	426/1272 (33%)
		ABC_membrane	<147..333	CDD:279056	47/196 (24%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	127/234 (54%)
		ABC_membrane	749..1019	CDD:279056	69/283 (24%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	128/243 (53%)
ABCB16	NP_189477.4	PTZ00265	21..1208	CDD:240339	426/1292 (33%)
		ABC_membrane	26..277	CDD:279056	59/289 (20%)
		ABC_MTABC3_MDL1_MDL2	346..583	CDD:213216	128/243 (53%)
		ABC_membrane	662..927	CDD:279056	68/278 (24%)
		ABC_MTABC3_MDL1_MDL2	981..1222	CDD:213216	128/243 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	90	1.000	Domainoid score	I2655
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790