Protein Alignment CG10226 and ABCB4

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_182223.1
• Gene: ABCB4 / 819314
• AraportID: AT2G47000
• Length: 1286
• Species: Arabidopsis thaliana
• Alignment Length: 1347
• Identity: 491/1347 - (36%)
• Similarity: 779/1347 - (57%)
• Gaps: 107/1347 - (7%)

  Fly     3 MTETREDVPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVF 67
            ::||:.|   .:.:|.....:||.:..||.: .|.:.:||.:...:|:|:::.|.:.:....|.|
plant    17 VSETKRD---KEEEEEVKKTEKKDEEHEKTK-TVPFYKLFAFADSFDFLLMILGTLGSIGNGLGF 77

  Fly    68 PIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLN 132
            |:..:::.:|:..|                     |:..||.:     .::.|.::.| :.:.:.
plant    78 PLMTLLFGDLIDAF---------------------GENQTNTT-----DKVSKVALKF-VWLGIG 115

  Fly   133 TLLMLF---SGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAV-RITDNMEKI 193
            |....|   ||  ::.:..|.|    .|:|..:.|..|||:|.:.|:..:....| |::.:...|
plant   116 TFAAAFLQLSG--WMISGERQA----ARIRSLYLKTILRQDIAFFDIDTNTGEVVGRMSGDTVLI 174

  Fly   194 RSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSY 258
            :..:.|.:|..::::...:...|::|:.||.|.|.::..|||.::..:.:|....|...:.|::|
plant   175 QDAMGEKVGKAIQLLATFVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTASRGQTAY 239

  Fly   259 VRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAG 323
            .:|::|||:.||:||||.:|.||:.....|:..|..|.|||..:|..:||....:..::|.:.|.
plant   240 AKAATVVEQTIGSIRTVASFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYAL 304

  Fly   324 SFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILD 388
            :.|||..|||          ::.||...|:.:|..::..:..:.:|||.|..||..:.:|..:.:
plant   305 AVWYGGKLIL----------DKGYTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAAAYKMFE 359

  Fly   389 VIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGC 453
            .|:|...||..|..||:|: .:||.:|.:||:|.||||.|..:.||.::.:..|.||||||.||.
plant   360 TIERRPNIDSYSTNGKVLD-DIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGTTVALVGQSGS 423

  Fly   454 GKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEAT 518
            ||||.:.|::|||||..|.||:||.:::::.:||:||.|.:|.||||||..||.:||.:||.:||
plant   424 GKSTVVSLIERFYDPQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKEDAT 488

  Fly   519 QKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSAL 583
            .:|::.||:.|||..|:..|.:|.||.:.|.|.||||||:||||:|||:::.|:|||||||||||
plant   489 TEEIKAAAELANASKFVDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSAL 553

  Fly   584 DYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMK-LEGFYHKM 647
            |..||::||.|||:....|||:||:||||.:|:|..|..|..||.||:|:|.||:| .||.|.::
plant   554 DAESERVVQEALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQL 618

  Fly   648 VTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPY-QLGTRNSIV--SLEK------NAEFQMKN 703
            :.:.      ||..:: |..||  |:||| .:|.: |...|.|.:  ||.|      |:.....|
plant   619 IRLQ------EEKKSD-ENAAE--EQKMS-SIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFN 673

  Fly   704 LNGL-----ANITMNQEIDDPRVPSANFIS-TFFRILGWARPEWSFLIIGAICAGLYGVTMPVFS 762
            :.|.     .|:..:||.||...|...... :.|||....:||...||:|:|.|...||.:|:|.
plant   674 MFGFPAGIDGNVVQDQEEDDTTQPKTEPKKVSIFRIAALNKPEIPVLILGSISAAANGVILPIFG 738

  Fly   763 VVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRC 827
            ::::.:..:..:| .:::.|.::..|||.:|:|.|:.:....|||||.:||..|..|:||..|..
plant   739 ILISSVIKAFFQP-PKKLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEK 802

  Fly   828 IMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALI 892
            :::.|:||||..|||.|.:.||||.|||:::|.:|..|:..:|..::.:..:.|||...|:||.:
plant   803 VVHMEVGWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFV 867

  Fly   893 CLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVE 957
            .|:..|.:..:.....:|.:..:...|::..|.|::|.:.:..|||||....|::::.:|.|:.|
plant   868 VLAMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMYSKKCE 932

  Fly   958 RYRHQILSRLKWRGLVNSLGKSLMFF----GYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLF 1018
            ......:.    :|:|:.:|....||    .||.:...|..:..|||..|:::.::...:.....
plant   933 GPMKNGIR----QGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFALTMAAM 993

  Fly  1019 ILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQ-SPESFEIQQNGNGTAYKTNVVQQGVSYRGLN 1082
            .::||.:.:|..:.|.::|..::.|:||:.:|. |.||..:..|          |:..:..|.::
plant   994 AISQSSSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDN----------VKGDIELRHVS 1048

  Fly  1083 FSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMD 1147
            |.||:||.:::.|:..|.|..|:||||||.|||||||.:.||.|:||||.|:|.:|...| ..:.
plant  1049 FKYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVEI-KSLR 1112

  Fly  1148 LKTLRRRLGIVSQEPSLFEKSIADNIGY---GDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDT 1209
            ||.||::.|:|||||.||.::|..||.|   ||.|.    .:|:.:|:::|||.||..|...|||
plant  1113 LKWLRQQTGLVSQEPILFNETIRANIAYGKGGDASE----SEIVSSAELSNAHGFISGLQQGYDT 1173

  Fly  1210 VLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAH 1274
            ::|.:|.|||||||||:|||||:|::||:|||||||||||.:||||||.|||.....||.||:||
plant  1174 MVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTIVVAH 1238

  Fly  1275 RLSTIQNANVICVIQAGKIVEQGSHSQLL-AKNGIYSKLYRCQTKAS 1320
            |||||:||:||.|::.|.|||:|.|..|: .|:|:|:.|.:....|:
plant  1239 RLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQLHLTAA 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	205/506 (41%)
		MdlB	723..1320	CDD:440747	232/606 (38%)
ABCB4	NP_182223.1	PTZ00265	46..1280	CDD:240339	482/1307 (37%)
		MdlB	705..1285	CDD:440747	232/599 (39%)