DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB4

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001323911.1	Gene:	ABCB4 / 819314	AraportID:	AT2G47000	Length:	1286	Species:	Arabidopsis thaliana

Alignment Length:	1347	Identity:	491/1347 - (36%)
Similarity:	779/1347 - (57%)	Gaps:	107/1347 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MTETREDVPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVF 67
            ::||:.|   .:.:|.....:||.:..||.: .|.:.:||.:...:|:|:::.|.:.:....|.|
plant    17 VSETKRD---KEEEEEVKKTEKKDEEHEKTK-TVPFYKLFAFADSFDFLLMILGTLGSIGNGLGF 77

  Fly    68 PIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLN 132
            |:..:::.:|:..|                     |:..||.:     .::.|.::.| :.:.:.
plant    78 PLMTLLFGDLIDAF---------------------GENQTNTT-----DKVSKVALKF-VWLGIG 115

  Fly   133 TLLMLF---SGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAV-RITDNMEKI 193
            |....|   ||  ::.:..|.|    .|:|..:.|..|||:|.:.|:..:....| |::.:...|
plant   116 TFAAAFLQLSG--WMISGERQA----ARIRSLYLKTILRQDIAFFDIDTNTGEVVGRMSGDTVLI 174

  Fly   194 RSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSY 258
            :..:.|.:|..::::...:...|::|:.||.|.|.::..|||.::..:.:|....|...:.|::|
plant   175 QDAMGEKVGKAIQLLATFVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTASRGQTAY 239

  Fly   259 VRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAG 323
            .:|::|||:.||:||||.:|.||:.....|:..|..|.|||..:|..:||....:..::|.:.|.
plant   240 AKAATVVEQTIGSIRTVASFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYAL 304

  Fly   324 SFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILD 388
            :.|||..|||          ::.||...|:.:|..::..:..:.:|||.|..||..:.:|..:.:
plant   305 AVWYGGKLIL----------DKGYTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAAAYKMFE 359

  Fly   389 VIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGC 453
            .|:|...||..|..||:|: .:||.:|.:||:|.||||.|..:.||.::.:..|.||||||.||.
plant   360 TIERRPNIDSYSTNGKVLD-DIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGTTVALVGQSGS 423

  Fly   454 GKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEAT 518
            ||||.:.|::|||||..|.||:||.:::::.:||:||.|.:|.||||||..||.:||.:||.:||
plant   424 GKSTVVSLIERFYDPQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKEDAT 488

  Fly   519 QKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSAL 583
            .:|::.||:.|||..|:..|.:|.||.:.|.|.||||||:||||:|||:::.|:|||||||||||
plant   489 TEEIKAAAELANASKFVDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSAL 553

  Fly   584 DYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMK-LEGFYHKM 647
            |..||::||.|||:....|||:||:||||.:|:|..|..|..||.||:|:|.||:| .||.|.::
plant   554 DAESERVVQEALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQL 618

  Fly   648 VTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPY-QLGTRNSIV--SLEK------NAEFQMKN 703
            :.:.      ||..:: |..||  |:||| .:|.: |...|.|.:  ||.|      |:.....|
plant   619 IRLQ------EEKKSD-ENAAE--EQKMS-SIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFN 673

  Fly   704 LNGL-----ANITMNQEIDDPRVPSANFIS-TFFRILGWARPEWSFLIIGAICAGLYGVTMPVFS 762
            :.|.     .|:..:||.||...|...... :.|||....:||...||:|:|.|...||.:|:|.
plant   674 MFGFPAGIDGNVVQDQEEDDTTQPKTEPKKVSIFRIAALNKPEIPVLILGSISAAANGVILPIFG 738

  Fly   763 VVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRC 827
            ::::.:..:..:| .:::.|.::..|||.:|:|.|:.:....|||||.:||..|..|:||..|..
plant   739 ILISSVIKAFFQP-PKKLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEK 802

  Fly   828 IMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALI 892
            :::.|:||||..|||.|.:.||||.|||:::|.:|..|:..:|..::.:..:.|||...|:||.:
plant   803 VVHMEVGWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFV 867

  Fly   893 CLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVE 957
            .|:..|.:..:.....:|.:..:...|::..|.|::|.:.:..|||||....|::::.:|.|:.|
plant   868 VLAMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMYSKKCE 932

  Fly   958 RYRHQILSRLKWRGLVNSLGKSLMFF----GYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLF 1018
            ......:.    :|:|:.:|....||    .||.:...|..:..|||..|:::.::...:.....
plant   933 GPMKNGIR----QGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFALTMAAM 993

  Fly  1019 ILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQ-SPESFEIQQNGNGTAYKTNVVQQGVSYRGLN 1082
            .::||.:.:|..:.|.::|..::.|:||:.:|. |.||..:..|          |:..:..|.::
plant   994 AISQSSSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDN----------VKGDIELRHVS 1048

  Fly  1083 FSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMD 1147
            |.||:||.:::.|:..|.|..|:||||||.|||||||.:.||.|:||||.|:|.:|...| ..:.
plant  1049 FKYPARPDVQIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVEI-KSLR 1112

  Fly  1148 LKTLRRRLGIVSQEPSLFEKSIADNIGY---GDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDT 1209
            ||.||::.|:|||||.||.::|..||.|   ||.|.    .:|:.:|:::|||.||..|...|||
plant  1113 LKWLRQQTGLVSQEPILFNETIRANIAYGKGGDASE----SEIVSSAELSNAHGFISGLQQGYDT 1173

  Fly  1210 VLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAH 1274
            ::|.:|.|||||||||:|||||:|::||:|||||||||||.:||||||.|||.....||.||:||
plant  1174 MVGERGIQLSGGQKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTIVVAH 1238

  Fly  1275 RLSTIQNANVICVIQAGKIVEQGSHSQLL-AKNGIYSKLYRCQTKAS 1320
            |||||:||:||.|::.|.|||:|.|..|: .|:|:|:.|.:....|:
plant  1239 RLSTIKNADVIAVVKNGVIVEKGKHDTLINIKDGVYASLVQLHLTAA 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	471/1258 (37%)
		ABC_membrane	<147..333	CDD:279056	56/186 (30%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	126/235 (54%)
		ABC_membrane	749..1019	CDD:279056	80/273 (29%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	130/243 (53%)
ABCB4	NP_001323911.1	PTZ00265	46..1280	CDD:240339	482/1307 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.790