DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and abcb5

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_001922717.3	Gene:	abcb5 / 798527	ZFINID:	ZDB-GENE-030131-6414	Length:	1338	Species:	Danio rerio

Alignment Length:	1372	Identity:	522/1372 - (38%)
Similarity:	788/1372 - (57%)	Gaps:	112/1372 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTMTETREDVPAADADEATPA-----AQKKKKTKEKAQPM--VSYTELFRYIAGWDYLVLLSGFV 58
            :.:..::::.|..|..|..|:     .:|.|.:|:..:||  |.:.:||||....:..::|.|.:
Zfish    25 VNLAYSQDEKPHEDKPEEPPSDSKHKGKKGKNSKDNKEPMKSVGFFQLFRYATCPEVFLMLIGLL 89

  Fly    59 AAFLQSLVFPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYE-ENMQELRKDS 122
            .|....:..|:..||:.::...|::       |..|..|:.| .|...:|.::. .|.......|
Zfish    90 CAAAHGVALPLMCVVFGQMTDSFVQ-------SGQTYNLTGF-NGNFTSNFTFTLNNTSTCLAGS 146

  Fly   123 VSFGILMTLNTLLMLFSGV---------YYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAK 178
            ...||...:......|.|:         :.|..|...|.|.|.|:|:::|.|.|.|::.|.|...
Zfish   147 PEIGIEPKMTKQAYFFIGIGGAVLVLGTFQVMLFLLTAAKQTKRIRQKYFHAILHQQMSWFDTHP 211

  Fly   179 DQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAV 243
            .....:|:||::..|..|:.:.:..:|:..|..|..:|:.|::||||.|.|:...|| |..::||
Zfish   212 IGELNIRLTDDINTINDGLGDKIAVFVQFFCSFISGLVIGFVFGWKLTLVILAVSPL-LAGSAAV 275

  Fly   244 -AHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSG 307
             :.....||.:|.::|.:|.:|.||::.||||||||.|::....:|:..|..|...|..|...:.
Zfish   276 WSKILASLTSKELTAYAKAGAVAEEILVAIRTVVAFNGQKKAVEKYEKNLVEAKDFGVKKAISTN 340

  Fly   308 LSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPIDERE-YTPAVVMIVISGIIVSANQISRTSP 371
            :|..:.:.::|.|.|.:||||..|         .:||.| ||...|:.|...:::....:.:.:|
Zfish   341 VSMGLTQFIVFATYALAFWYGTKL---------SVDEPENYTIGRVLTVFFSVMIGTFSLGQGAP 396

  Fly   372 FLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLN 436
            .||..|.|||:|..:...||....||..||.|...: .::|.:||:::.|.||:|:||.:|:|::
Zfish   397 NLEAIAKARGAAYEVYKTIDMPRPIDSSSKEGHKPD-RVRGDIEFKNINFNYPSRKDVTILQGMS 460

  Fly   437 VVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVL 501
            :.|..|:|:||||.|||||||.||||||||||..|:|.|||.|:|..|::|||.|:.:|.|||||
Zfish   461 LKVPHGKTIALVGASGCGKSTTIQLLQRFYDPDSGEVTLDGHDIRSLNVRWLRENMGIVSQEPVL 525

  Fly   502 FQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARA 566
            |..:|.||||:|:.:||..::|.|.|.|||:|||..|....:|.:.|:|.||||||:||||||||
Zfish   526 FGTTIAENIRYGREDATDADIEQAIKEANAYDFISKLPDKLNTMVGERGAQLSGGQKQRIAIARA 590

  Fly   567 LIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQ 631
            |::.||||||||||||||..||.:||||||||..||||:|::||||.||.|..|.....|:.|||
Zfish   591 LVKNPKILLLDEATSALDTQSESIVQAALDKARAGRTTIVIAHRLSTIRSADIIAGFSEGRVVEQ 655

  Fly   632 GTHEELMKLEGFYHKMVTVH---------------SYDDSAEELLNE------LEEVAEIKERKM 675
            |:|.|||..:|.|:.:||..               :.|||.||...:      ||...|:|..:.
Zfish   656 GSHRELMAKKGVYYSLVTQQTSGRQNEELDANEDDTQDDSEEETGEDSSDPEILEGGVEMKLERG 720

  Fly   676 SYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFFRILGWARPE 740
            |:         |.|:....|....:.|:.....:....:| :.|.:|       |.:||...:|:
Zfish   721 SF---------RKSLKRSSKRRSSRKKSKKSRKDKKAKKE-EIPEMP-------FTKILALNKPD 768

  Fly   741 WSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASM-AIISLVIGIAAGVVCYI 804
            |.:|::|...:.:.|...|..:::.|::.|..|:| |.||..|...| :::.|:||:.|.:..:.
Zfish   769 WPYLVVGTFASLVGGAVYPCVAILFAKIIGVFAEP-DPEVKRQKTMMFSLLYLLIGVVAFLTYFF 832

  Fly   805 QTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNII 869
            |.|.|..:|..||.|:||:.|:.|:.||:||||...|::|.|:.:|:.||:.|:||.|..|.
Zfish   833 QGFMFGKSGELLTMRLRSQAFKAIVRQEIGWFDDNNNAVGILTTKLATDASLVKGAAGSRLG--- 894

  Fly   870 QAFTNFIC----SIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIAT 930
             ..||.||    ::.:||.:.|:|.|:.|:..||:..:...:.|.......|::..||.:.:|:|
Zfish   895 -LATNTICALLIAVIVAFVFCWQLTLLILACVPFLTGANFIQLRATAGHTSKDQSALEMSGKIST 958

  Fly   931 ETITQIRTVAGLRREEELI-KIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGH 994
            ||:...:||..|.||:... |..|.....|:.. |.:....|:..:|.:::.:...|....:|..
Zfish   959 ETVENFKTVVALTREDVFFHKFIDSLSTPYKAS-LCKAPIYGITFALAQAIPYLVNAAIFRFGAW 1022

  Fly   995 MCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQI-------QS 1052
            :.|....::|.:..:.:.:::....:.||.:|.|.|..|..:|.|:.:::::||:|       :.
Zfish  1023 LIAHCYTEYENVFLVFSVIVFAAMNIGQSSSFAPDFAKAKAAAGRIIQLLEKKPEIDIYDESGER 1087

  Fly  1053 PESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGK 1117
            |.:|    :||            :.::.:.||||:||::||||..|:.:.||||:||||:||.||
Zfish  1088 PSTF----SGN------------IDFKDVQFSYPTRPNVKVLQGLNVSVRQGQTLALVGSSGCGK 1136

  Fly  1118 STCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQV 1182
            ||.:|||.|:|||..|::|:|... ...::|..||.::|:|||||.||:.:|::||.|||.||.|
Zfish  1137 STTIQLLERFYDPAGGQVLVDGRD-SKSVNLAWLRTQMGLVSQEPILFDCTISENIQYGDNSRTV 1200

  Fly  1183 PMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSA 1247
            ..::|.||||.||.|.||::||.:|:|.:|.||||||||||||||||||:||.||:|||||||||
Zfish  1201 TQEEIEEAAKKANIHNFILTLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRKPKLLLLDEATSA 1265

  Fly  1248 LDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKL 1312
            ||.:||::||.|||.|..|||||||||||:|||||::|.|:|.||:||||:|:||:||...|..|
Zfish  1266 LDTESEKIVQAALDEARLGRTCIVIAHRLTTIQNADIIVVVQNGKVVEQGTHAQLMAKQEAYFAL 1330

  Fly  1313 YRCQTKA 1319
            ...|..|
Zfish  1331 VNAQVSA 1337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	499/1275 (39%)
		ABC_membrane	<147..333	CDD:279056	64/186 (34%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	137/234 (59%)
		ABC_membrane	749..1019	CDD:279056	78/275 (28%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	143/239 (60%)
abcb5	XP_001922717.3	PTZ00265	48..1328	CDD:240339	514/1338 (38%)
		ABC_membrane	88..389	CDD:279056	89/318 (28%)
		ABC_MTABC3_MDL1_MDL2	438..675	CDD:213216	139/236 (59%)
		ABC_membrane	776..1046	CDD:279056	78/275 (28%)
		ABC_MTABC3_MDL1_MDL2	1095..1334	CDD:213216	143/239 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7260
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.730