DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and TAP1

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_000584.3	Gene:	TAP1 / 6890	HGNCID:	43	Length:	748	Species:	Homo sapiens

Alignment Length:	676	Identity:	203/676 - (30%)
Similarity:	333/676 - (49%)	Gaps:	115/676 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LFRYIAGW------DYLVLL------SGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGTS-- 91
            |||.:..|      |...||      :.||.::..:|.   |..::.:|.::::..  |||.|
Human   112 LFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALP---AAALWHKLGSLWVPG--GQGGSGN 171

  Fly    92 ----------SVTIGLSLF---------GGGKI------LTNASYEENMQELRKDSVSFGILMTL 131
                      |.|..||||         |...|      ||:...::...:....:::...::|:
Human   172 PVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTI 236

  Fly   132 NTLLMLF--SGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIR 194
            .:.::.|  .|:|     |.....:...::.|.|.|.||||..:....:..|...|:|::...:.
Human   237 ASAVLEFVGDGIY-----NNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLS 296

  Fly   195 SGIAENLG----HYVEIMCDVIISVVLSFIYGW---KLALAIVFYIPLTLVVNSAVAHYQGKLTG 252
            ..::|||.    :.|..:|  ::.::|     |   .|.:..:..:||..::...|..:...|..
Human   297 DSLSENLSLFLWYLVRGLC--LLGIML-----WGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEV 354

  Fly   253 QEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKP----------ALKAGKWKGAFSG 307
            |.:.|..::|.|..|.:.|:.||.:|..|..|:.::...|:.          |.....|..:.||
Human   355 QVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISG 419

  Fly   308 LSDTVMK-AMLFITG----AGSFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQIS 367
            :   ::| .:|:|.|    :|:...| ||:.:.      :.:.::|.||.:::
Human   420 M---LLKVGILYIGGQLVTSGAVSSG-NLVTFV------LYQMQFTQAVEVLL------------ 462

  Fly   368 RTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVL 432
               ........|.||:..|.:.:|||....|   :|.:....|:|.|:|:||.|.||.|.||:||
Human   463 ---SIYPRVQKAVGSSEKIFEYLDRTPRCPP---SGLLTPLHLEGLVQFQDVSFAYPNRPDVLVL 521

  Fly   433 RGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQ 497
            :||...:..|:..|||||:|.||||...|||..|.|..||:||||:.:.:|..::|...:|.|||
Human   522 QGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQ 586

  Fly   498 EPVLFQGSIGENIRHG---KPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQ 559
            ||.:|..|:.|||.:|   ||  |.:|:..||..:.||.||..|.:||||::.|.|.||||||||
Human   587 EPQVFGRSLQENIAYGLTQKP--TMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQ 649

  Fly   560 RIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACK--GRTTLVVSHRLSAIRHAHRIVY 622
            .:|:|||||::|.:|:||:||||||.:|:..|:..|.::.:  .|:.|:::..||.:..|..|::
Human   650 AVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILF 714

  Fly   623 IENGKAVEQGTHEELMKLEGFYHKMV 648
            :|.|...|.|||::||:.:|.|..||
Human   715 LEGGAIREGGTHQQLMEKKGCYWAMV 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	191/624 (31%)
		ABC_membrane	<147..333	CDD:279056	47/207 (23%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	112/240 (47%)
		ABC_membrane	749..1019	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	201/674 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910