Protein Alignment CG10226 and ABCC8

DIOPT Version :9

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_016873686.1
• Gene: ABCC8 / 6833
• HGNCID: 59
• Length: 1604
• Species: Homo sapiens
• Alignment Length: 1492
• Identity: 346/1492 - (23%)
• Similarity: 607/1492 - (40%)
• Gaps: 396/1492 - (26%)

  Fly    70 AIVVYSELVAMF-------IERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVS--- 124
            |:..|..|...|       |:.|  ||..::...||...|.:::.::::     .:..|.:.
Human   259 ALTNYQRLCEAFDAQVRKDIQGT--QGARAIWQALSHAFGRRLVLSSTF-----RILADLLGFAG 316

  Fly   125 ----FGILMTL---NTLLM---LFSGVYYVDAFNRLA--------LKLTVRMRREFFKAT----- 166
                |||:..|   |.:..   .|.|||:|.:...||        |.|.:.::|.|.:|:
Human   317 PLCIFGIVDHLGKENDVFQPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAI 381

  Fly   167 -----LRQEIGWHDMAKDQNFAVRI-TDN--MEKIRSG-------IAENLGHYVEIMCDVIISVV 216
                 ||..|    ..|..|..:.: |.|  |.::.:|       |..|...:...:|..:.::.
Human   382 ETGINLRGAI----QTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMP 442

  Fly   217 LSFIYGWKLALAIVFYI-PLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGG 280
            :..|.|    :.:::|| .::.::.:||......:      .|..|:.:.:    |.|:.:.:..
Human   443 VQIIVG----VILLYYILGVSALIGAAVIILLAPV------QYFVATKLSQ----AQRSTLEYSN 493

  Fly   281 ER----SESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIP 341
            ||    :|.||...|||  |.|  |:..|....:|..:..:....|.:.:...::   :.:.:||
Human   494 ERLKQTNEMLRGIKLLK--LYA--WENIFRTRVETTRRKEMTSLRAFAIYTSISI---FMNTAIP 551

  Fly   342 I--------------DEREYTPAVVMIVIS--GIIVSANQISRTSPFLETFAMARGSASAILDVI 390
            |              .|.:::|:|....:|  .|:|        :|.....::.|.:..|::.|
Human   552 IAAVLITFVGHVSFFKEADFSPSVAFASLSLFHILV--------TPLFLLSSVVRSTVKALVSV- 607

  Fly   391 DRTSLIDPLSKA---------------GKILNYGLKGAVE----------------------FRD 418
              ..|.:.||.|               |....|   .|||                      .|.
Human   608 --QKLSEFLSSAEIREEQCAPHEPTPQGPASKY---QAVEEGLPSLHSSQPSGSSPPNHPQPLRV 667

  Fly   419 VFFRYPARED-------------------------------------VIVLRGLNVVVEEGQTVA 446
            |..:.|||||                                     :..|..:.:.:..||...
Human   668 VNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTM 732

  Fly   447 LVGPSGCGKSTCIQL----LQRFYDPVF-GQVLLDGE---------------DVRKYNIKWLRSN 491
            :||..|||||:.:..    :|:....|| ...|.|.|               |:||      |..
Human   733 IVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPERETATDLDIRK------RGP 791

  Fly   492 IAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGG 556
            :|...|:|.|...::.|||....|...|: .:...:|.:....|..|..|..|.|.|:|:.||||
Human   792 VAYASQKPWLLNATVEENIIFESPFNKQR-YKMVIEACSLQPDIDILPHGDQTQIGERGINLSGG 855

  Fly   557 QRQRIAIARALIQQPKILLLDEATSALDYH-SEKLVQAAL------DKACKGRTTLVVSHRLSAI 614
            |||||::||||.|...::.||:..||||.| |:.|:||.:      ||    ||.::|:|:|..:
Human   856 QRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDK----RTVVLVTHKLQYL 916

  Fly   615 RHAHRIVYIENGKAVEQGTHEELMKLEG--FYHKMVTVHSYDDSAEELLNELEEVAEIKERKMSY 677
            .||..|:.:::|....:||.::..:.|.  |.|....::..|       .|||: ..:.|||.:
Human   917 PHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQD-------QELEK-ETVTERKAT- 972

  Fly   678 EVEPYQ-----LGTRNSIVSLEKNAEFQM------KNLNGLANITMNQEIDDPRVPSANFISTFF 731
              ||.|     :.:|:.::..|:..|.:.      .||:.:    ::|..:.|....|.::|:
Human   973 --EPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSM----LHQRAEIPWRACAKYLSS-- 1029

  Fly   732 RILGWARPEWSFLIIGAICAGLYGVTMPVFS-----VVLAELYGSLAKPTD-------------- 777
                               ||:..:::.|||     :||..:...|||.||
Human  1030 -------------------AGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSL 1075

  Fly   778 --EEVLEQSASMAIISLV--IGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDR 838
              |..|:|:....:.:::  :||   |:|.:.:......|:.:..|:.......|:...|.:|:
Human  1076 SQECTLDQTVYAMVFTVLCSLGI---VLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFE- 1136

  Fly   839 KENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVA- 902
             ...:|::..|.|.|..::...|...|..:.:  :..:|..|        ||:|...|..|:||
Human  1137 -TTPLGSILNRFSSDCNTIDQHIPSTLECLSR--STLLCVSA--------LAVISYVTPVFLVAL 1190

  Fly   903 -SIVFEARFGEK---SALKEKEVLEETSRIA-----TETITQIRTVAGLRRE----EELIKIYDK 954
             .:.....|.:|   .|.::.:.|::|:::.     .||:..:.|:...|.|    ::|::..|.
Human  1191 LPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDS 1255

  Fly   955 EVERYRHQILS------------RLKWRG-----------LVNSLGKSLMFFGYAVTLTYGGHMC 996
                  :.|.|            |:::.|           :.|||.:.|......:.|||.
Human  1256 ------NNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYA---- 1310

  Fly   997 ADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQN 1061
                      :.:||.:.:    :.::||   .....|.:..|::.::  |.:.:|.|.....
Human  1311 ----------LMVSNYLNW----MVRNLA---DMELQLGAVKRIHGLL--KTEAESYEGLLAP-- 1354

  Fly  1062 GNGTAYKTNVVQQG-VSYRGLNFSYPS--RPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQL 1123
               :....|...|| :..:.|:..|.|  :|   ||::.|..|..||.:.:.|.:|||||:....
Human  1355 ---SLIPKNWPDQGKIQIQNLSVRYDSSLKP---VLKHVNALIAPGQKIGICGRTGSGKSSFSLA 1413

  Fly  1124 LMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQII 1188
            ..|..|..||.|:||...| ..:.|.|||.||.|:.|:|.||..:|..|:   |..|:.....:.
Human  1414 FFRMVDTFEGHIIIDGIDI-AKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPERKCSDSTLW 1474

  Fly  1189 EAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSE 1253
            ||.::|.....:.:||...|.::...|...|.||:|...:|||.||...|.::||||:::|..:|
Human  1475 EALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE 1539

  Fly  1254 RVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLA-KNGIYSKLYR 1314
            .::|:.:.:|.:.||.:.||||:.||.:|:::.|::.|.|:|.....:||: |:.:::...|
Human  1540 NILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVR 1601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	342/1476 (23%)
		ABC_membrane	<147..333	CDD:279056	43/218 (20%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	87/322 (27%)
		ABC_membrane	749..1019	CDD:279056	64/329 (19%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	81/242 (33%)
ABCC8	XP_016873686.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910