DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and Abcb10

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	634	Identity:	224/634 - (35%)
Similarity:	341/634 - (53%)	Gaps:	76/634 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 DDPRVPSANFISTFFRILGWARPE-------WSFLIIGAICAGLYGVTM--PVF-SVVLAELYGS 771
            |..|.|:|...|..:::||..|||       ..||.:.::      :||  |.| ..::..:|.:
Mouse   109 DSQRRPAATGRSEVWKLLGLVRPERGRLSAAVGFLAVSSV------ITMSAPFFLGRIIDVIYTN 167

  Fly   772 LAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWF 836
            .::...:.:....|.:..:.|....|.|    |:.:....:|..:..|:|:..|..|:.||:.:|
Mouse   168 PSEGYGDSLTRLCAVLTCVFLCGAAANG----IRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFF 228

  Fly   837 DRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMV 901
            |:...  |.|..|||.|.|.:..::...||:.::|.......:.:.|..|..||...||..|.:.
Mouse   229 DKTRT--GELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSVVPPIS 291

  Fly   902 ASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQI--L 964
            ...|...|:..|.:...::.|.|.:::|.|.|..|||:....:|.       .|||:|..::  |
Mouse   292 VLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEM-------TEVEKYTGRVDQL 349

  Fly   965 SRLKWRGLVNSLGKSLMFFGYA--------VTLTYGG-------HMCADGKIKFETIMKISNTML 1014
            .:|..:..:...|    |||.|        :::.|.|       ||         |:.::|:.::
Mouse   350 LQLAQKEALARAG----FFGAAGLSGNLIVLSVLYKGGLLMGSAHM---------TVGELSSFLM 401

  Fly  1015 YGLFILAQSLAFTPAFNAALL----SANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQG 1075
            |. |.:..|:....:|.:.|:    :..|::|:::|:|::...|...:.:       ||  .|..
Mouse   402 YA-FWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNEGMVLDE-------KT--FQGA 456

  Fly  1076 VSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQE 1140
            :.:|.::|:||:||.:.|.|:|:|.|..|...||||.|||||||.|.||:|.|||:.|.:.:|..
Mouse   457 LEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGH 521

  Fly  1141 SIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYG-DTSRQVPMQQIIEAAKMANAHEFIMSLP 1204
            .| ..::...||.::|.|||||.||..|:|:||.|| |....|..||:..||::|||.|||.|.|
Mouse   522 DI-RQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFP 585

  Fly  1205 AQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTC 1269
            ..:|||:|.||..||||||||||||||:::|||||||||||||||.::|.:||:|||....|||.
Mouse   586 QGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTV 650

  Fly  1270 IVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAK-NGIYSKLYRCQT 1317
            ::||||||||:|||.:.|:..|||.|.|:|.:||.| ||:|.||...|:
Mouse   651 LIIAHRLSTIKNANFVAVLDHGKICEHGTHEELLLKPNGLYRKLMNKQS 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	221/626 (35%)
		ABC_membrane	<147..333	CDD:279056
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216
		ABC_membrane	749..1019	CDD:279056	66/289 (23%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	133/241 (55%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	221/627 (35%)
		ABC_membrane	142..403	CDD:279056	67/292 (23%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	133/240 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910