DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB4

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_011514610.3	Gene:	ABCB4 / 5244	HGNCID:	45	Length:	1384	Species:	Homo sapiens

Alignment Length:	1321	Identity:	534/1321 - (40%)
Similarity:	786/1321 - (59%)	Gaps:	86/1321 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSE 76
            :|:.|.....:.|:|:.|.|...|:....||||....|.|.:..|.:.|.......|:.::|:.|
Human   106 SAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGE 170

  Fly    77 LVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELR--KDSVSFGILMTLNTLLMLFS 139
            :...|:: |.|..:..|...|||...||||     ||.|....  ...:..|:|:
Human   171 MTDKFVD-TAGNFSFPVNFSLSLLNPGKIL-----EEEMTRYAYYYSGLGAGVLV---------- 219

  Fly   140 GVYYVDAFNRLALKLTVR-MRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGH 203
            ..|...:|..||....:| :|::||.|.|||||||.|:........|:||::.||..||.:.:|.
Human   220 AAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGM 284

  Fly   204 YVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAV-AHYQGKLTGQEQSSYVRASSVVEE 267
            :.:.:.......::.||.||||.|.|:...|: |.:::|| |......:.:|.::|.:|.:|.||
Human   285 FFQAVATFFAGFIVGFIRGWKLTLVIMAISPI-LGLSAAVWAKILSAFSDKELAAYAKAGAVAEE 348

  Fly   268 VIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLI 332
            .:||||||:||||:..|..||...|:.|.:.|..|...:.:|..:...:::.:.|.:||||:.|:
Human   349 ALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLV 413

  Fly   333 LYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLID 397
            :          .:|||....|.|...|::.|..:.:.:|.::.||.|||:|..|.|:||....||
Human   414 I----------SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKID 468

  Fly   398 PLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLL 462
            ..|:.|...: .:||.:||.||.|.||:|.:|.:|:|||:.|:.||||||||.|||||||.:||:
Human   469 SFSERGHKPD-SIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLI 532

  Fly   463 QRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAK 527
            ||.|||..|.:.:||:|:|.:|:.:||..|.||.||||||..:|.|||.:|:...|..|::.|.|
Human   533 QRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVK 597

  Fly   528 AANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQ 592
            .|||::||:.|.:.:||.:.|:|.||||||:|||||||||::.||||||||||||||..||..||
Human   598 EANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQ 662

  Fly   593 AALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSA 657
            ||||||.:||||:|::||||.:|:|..|...|:|..||||:|.||||.||.|.|:|.:.:.....
Human   663 AALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQI 727

  Fly   658 EELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEID--DPR 720
            :      .|..|:.:.|.:..:.|....:|....|.:||    :|| :.:...:::.|.|  :..
Human   728 Q------SEEFELNDEKAATRMAPNGWKSRLFRHSTQKN----LKN-SQMCQKSLDVETDGLEAN 781

  Fly   721 VPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSA 785
            ||..:|:    ::|...:.||.:.::|.:||...|...|.|||:.:|:. ::..|.|:.|.:|..
Human   782 VPPVSFL----KVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEII-AIFGPGDDAVKQQKC 841

  Fly   786 SM-AIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSAR 849
            :: ::|.|.:||.:....::|.|.|..||..||.|:||..|:.::.|:|.|||..:||.||||.|
Human   842 NIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTR 906

  Fly   850 LSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKS 914
            |:.|||.||||.|..|:.|.|...|....|.|:|.|.|:|.|:.|:..|.:..|.:.|.:....:
Human   907 LATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGN 971

  Fly   915 ALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIY-DKEVERYRHQILSRLKWRGLVNSLGK 978
            |.::|:.||...:||||.|..||||..|.:|.:...:| :|....||:.: .:....|:..|:.:
Human   972 AKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSV-QKAHIYGITFSISQ 1035

  Fly   979 SLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEI 1043
            :.|:|.||....:|.::..:|.::|..::.:.:.:::|...|..:.:|.|.:..|.|||..::.:
Human  1036 AFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFML 1100

  Fly  1044 IDRKPQIQS-------PESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDI 1101
            .:|:|.|.|       |:.||    ||            :::..:.|:||:|.::.|||..:|::
Human  1101 FERQPLIDSYSEEGLKPDKFE----GN------------ITFNEVVFNYPTRANVPVLQGLSLEV 1149

  Fly  1102 NQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILID--------QESIHHDMDLKTLRRRLGIV 1158
            .:|||:||||:||.||||.||||.|:|||..|.:.:|        ||:  ..::::.||.:||||
Human  1150 KKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEA--KKLNVQWLRAQLGIV 1212

  Fly  1159 SQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQK 1223
            ||||.||:.|||:||.|||.||.|...:|:.|||.||.|.||.:||.:|:|.:|.||||||||||
Human  1213 SQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQK 1277

  Fly  1224 QRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVI 1288
            ||||||||::|.|:||||||||||||.:||:|||:|||.|..|||||||||||||||||::|.|.
Human  1278 QRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVF 1342

  Fly  1289 QAGKIVEQGSHSQLLAKNGIY 1309
            |.|::.|.|:|.||||:.|||
Human  1343 QNGRVKEHGTHQQLLAQKGIY 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	516/1252 (41%)
		ABC_membrane	<147..333	CDD:279056	67/187 (36%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	138/234 (59%)
		ABC_membrane	749..1019	CDD:279056	92/271 (34%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	142/242 (59%)
ABCB4	XP_011514610.3	AAA	108..1369	CDD:333001	533/1319 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2881
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H136368
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.730