DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB1

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001335874.1	Gene:	ABCB1 / 5243	HGNCID:	40	Length:	1350	Species:	Homo sapiens

Alignment Length:	1329	Identity:	533/1329 - (40%)
Similarity:	784/1329 - (58%)	Gaps:	112/1329 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQ 88
            |.:|.|::.:|.||...:|||....|.|.::.|.:||.:.....|:.::|:.|:..:|
Human    92 KSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIF------- 149

  Fly    89 GTSSVTIGLSLFGGGKILTNASYEENMQEL------RKDSVSFGILMTL----NTLLMLFSGV-- 141
                              .||.   |:::|      |.|....|..|.|    ......:||:
Human   150 ------------------ANAG---NLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGA 193

  Fly   142 ------YYVDAFNRLALKLTV-RMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAE 199
                  |...:|..||....: ::|::||.|.:||||||.|:........|:||::.||..||.:
Human   194 GVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGD 258

  Fly   200 NLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAV-AHYQGKLTGQEQSSYVRASS 263
            .:|.:.:.|.......::.|..||||.|.|:...|: |.:::|| |......|.:|..:|.:|.:
Human   259 KIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPV-LGLSAAVWAKILSSFTDKELLAYAKAGA 322

  Fly   264 VVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYG 328
            |.|||:.|||||:||||::.|..||:..|:.|.:.|..|...:.:|......:::.:.|.:||||
Human   323 VAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYG 387

  Fly   329 ANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRT 393
            ..|:|          ..||:...|:.|...:::.|..:.:.||.:|.||.|||:|..|..:||..
Human   388 TTLVL----------SGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNK 442

  Fly   394 SLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTC 458
            ..||..||:|...: .:||.:|||:|.|.||:|::|.:|:|||:.|:.||||||||.|||||||.
Human   443 PSIDSYSKSGHKPD-NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTT 506

  Fly   459 IQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVE 523
            :||:||.|||..|.|.:||:|:|..|:::||..|.||.||||||..:|.||||:|:...|..|:|
Human   507 VQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIE 571

  Fly   524 DAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSE 588
            .|.|.|||:|||:.|...:||.:.|:|.||||||:|||||||||::.||||||||||||||..||
Human   572 KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESE 636

  Fly   589 KLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSY 653
            .:||.|||||.|||||:|::||||.:|:|..|...::|..||:|.|:||||.:|.|.|:||:.:.
Human   637 AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTA 701

  Fly   654 DDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSL---------EKNAEFQMKNLNGLAN 709
            .:..     |||..|:  |.|.  |::..::.:.:|..||         .:.::.|.:.|:
Human   702 GNEV-----ELENAAD--ESKS--EIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLS---- 753

  Fly   710 ITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAK 774
               .:|..|..:|..    :|:||:.....||.:.::|..||.:.|...|.|:::.:::.|...:
Human   754 ---TKEALDESIPPV----SFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTR 811

  Fly   775 PTDEEVLEQSASM-AIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDR 838
            ..|.|...|:::: :::.|.:||.:.:..::|.|.|..||..||.|:|...||.::.|::.|||.
Human   812 IDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 876

  Fly   839 KENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVAS 903
            .:|:.|||:.||:.|||.|:||||..|:.|.|...|....|.|:|.|.|:|.|:.|:..|.:..:
Human   877 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIA 941

  Fly   904 IVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVE-RYRHQILSRL 967
            .|.|.:.....|||:|:.||.:.:||||.|...|||..|.:|::...:|.:.:: .||:. |.:.
Human   942 GVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNS-LRKA 1005

  Fly   968 KWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNA 1032
            ...|:..|..:::|:|.||....:|.::.|...:.||.::.:.:.:::|...:.|..:|.|.:..
Human  1006 HIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1070

  Fly  1033 ALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKT-----NVVQQGVSYRGLNFSYPSRPHIK 1092
            |.:||..:..||::.|.|.|              |.|     |.::..|::..:.|:||:||.|.
Human  1071 AKISAAHIIMIIEKTPLIDS--------------YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIP 1121

  Fly  1093 VLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGI 1157
            |||..:|::.:|||:||||:||.||||.||||.|:|||..||:|:|.:.|.. ::::.||..|||
Human  1122 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKR-LNVQWLRAHLGI 1185

  Fly  1158 VSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQ 1222
            |||||.||:.|||:||.|||.||.|..::|:.|||.||.|.||.|||.:|.|.:|.|||||||||
Human  1186 VSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQ 1250

  Fly  1223 KQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICV 1287
            |||||||||:||.|.||||||||||||.:||:|||:|||.|..|||||||||||||||||::|.|
Human  1251 KQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVV 1315

  Fly  1288 IQAGKIVEQGSHSQLLAKNGIYSKLYRCQ 1316
            .|.|::.|.|:|.||||:.|||..:...|
Human  1316 FQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	515/1265 (41%)
		ABC_membrane	<147..333	CDD:279056	66/187 (35%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	139/234 (59%)
		ABC_membrane	749..1019	CDD:279056	87/271 (32%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	148/239 (62%)
ABCB1	NP_001335874.1	PTZ00265	123..1337	CDD:240339	519/1289 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2881
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.730