Protein Alignment CG10226 and ABCC1

DIOPT Version :9

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_016878726.1
• Gene: ABCC1 / 4363
• HGNCID: 51
• Length: 1549
• Species: Homo sapiens
• Alignment Length: 1364
• Identity: 319/1364 - (23%)
• Similarity: 565/1364 - (41%)
• Gaps: 306/1364 - (22%)

  Fly    47 GWDYLVLLSGFVAAFLQSLV----FPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILT 107
            |:.|.|||  ||.|.||:||    |.|..|             .|....:..|| :::....::|
Human   381 GYFYTVLL--FVTACLQTLVLHQYFHICFV-------------SGMRIKTAVIG-AVYRKALVIT 429

  Fly   108 NASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKLTVRMRREFFKATLRQEIG 172
            |::        ||.|       |:..::.|.|    |||
Human   430 NSA--------RKSS-------TVGEIVNLMS----VDA-------------------------- 449

  Fly   173 WHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGW----KLALAIVFYI 233
                   |.|.                :|..|:.::....:.|:|:....|    ...||.|..:
Human   450 -------QRFM----------------DLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVM 491

  Fly   234 PLTLVVNSAVAHYQGKLTGQEQSSYVRAS----SVVEEVIGAIRTVVAFGGERSESLRYDSLLKP 294
            .|.:.||:.:|    ..|...|.:::::.    .::.|::..|:.:..:..|.:...:..::.:.
Human   492 VLMVPVNAVMA----MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQE 552

  Fly   295 ALKAGKWKGAFSGLSDTVMKAMLFITGAGSF-WYGANLIL------YYRDPSIPIDEREYTPA-- 350
            .||              |:|...:::..|:| |.....::      .|    :.|||.....|
Human   553 ELK--------------VLKKSAYLSAVGTFTWVCTPFLVALCTFAVY----VTIDENNILDAQT 599

  Fly   351 ----------------VVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPL 399
                            ::.:|||.|:.::..:.|...||....:..       |.|:|..:.|.
Human   600 AFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEP-------DSIERRPVKDG- 656

  Fly   400 SKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQR 464
                     |...::..|:..|.: ||.|...|.|:...:.||..||:||..|||||:.:..|..
Human   657 ---------GGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 711

  Fly   465 FYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHG--KPEATQKEVEDAAK 527
            ..|.|.|.|.:.|             ::|.|.|:..:...|:.|||..|  ..|...:.|..|
Human   712 EMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQA-- 761

  Fly   528 AANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLV- 591
            .|...|..| |..|..|:|.||||.|||||:||:::|||:.....|.|.|:..||:|.|..|.:
Human   762 CALLPDLEI-LPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIF 825

  Fly   592 ------QAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTV 650
                  :..|    |.:|.::|:|.:|.:.....|:.:..||..|.|:::||:..:|.:.:.:..
Human   826 ENVIGPKGML----KNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRT 886

  Fly   651 HS---YDDSAEELLNELEEVA----EIKERKMSYEVE-------PYQLGTRNSI---VSLEKNAE 698
            ::   .:..|||  |.:..|:    |.|:.:....|.       ..||.:.:|.   :|...|:.
Human   887 YASTEQEQDAEE--NGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNST 949

  Fly   699 FQMKNLNGLANITMN-QEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFS 762
            .:::........|.. .|.|..:..... :|.:          |.::  .||  ||:...:.:|.
Human   950 AELQKAEAKKEETWKLMEADKAQTGQVK-LSVY----------WDYM--KAI--GLFISFLSIFL 999

  Fly   763 VV------LAELYGSLAKPTDEEVLEQSASMAIISL----VIGIAAGVVCYIQTFFFNLAGVWLT 817
            .:      ||..|. |:..||:.::..:.....:.|    .:||:.|:..:..:...::.|:..:
Human  1000 FMCNHVSALASNYW-LSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFGYSMAVSIGGILAS 1063

  Fly   818 TRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIA 882
            ..:.......|:...|.:|:|..:  |.|..|.|.:..:|...|    ..:|:.|...:.::..|
Human  1064 RCLHVDLLHSILRSPMSFFERTPS--GNLVNRFSKELDTVDSMI----PEVIKMFMGSLFNVIGA 1122

  Fly   883 FPYSWELALICLSTSPFMVASIV---------FEARFGEKSALKEKEVLEETSRIA-----TETI 933
                   .::.|..:|  :|:|:         |..||...|:.:.|. ||..||..     .||:
Human  1123 -------CIVILLATP--IAAIIIPPLGLIYFFVQRFYVASSRQLKR-LESVSRSPVYSHFNETL 1177

  Fly   934 TQIRTVAGLRREEELIKIYDKEVER----YRHQILSRLKWRGL-VNSLGKSLMFFGYAVTLTYGG 993
            ..:..:.....:|..|...|.:|:.    |...|::. :|..: :..:|..::.|. |:......
Human  1178 LGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN-RWLAVRLECVGNCIVLFA-ALFAVISR 1240

  Fly   994 HMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRM------YEIIDRKPQIQS 1052
            |..:.|              |.||.: :.||..|...|..:..::.|      .|.:....:.:.
Human  1241 HSLSAG--------------LVGLSV-SYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEK 1290

  Fly  1053 PESFEIQQNGNGTAYKTNVVQQG-VSYRGLNFSYPSRPHIK-VLQNFNLDINQGQTVALVGASGS 1115
            ...::||:    ||..::..|.| |.:|  |:....|..:. ||::.|:.||.|:.|.:||.:|:
Human  1291 EAPWQIQE----TAPPSSWPQVGRVEFR--NYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGA 1349

  Fly  1116 GKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSR 1180
            |||:....|.|..:..||:|:||..:| ..:.|..||.::.|:.|:|.||..|:..|:   |...
Human  1350 GKSSLTLGLFRINESAEGEIIIDGINI-AKIGLHDLRFKITIIPQDPVLFSGSLRMNL---DPFS 1410

  Fly  1181 QVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEAT 1245
            |...:::..:.::|:..:|:.:||.:.|......|..||.||:|.:.:|||::|..|||:|||||
Human  1411 QYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1475

  Fly  1246 SALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIY 1309
            :|:|.:::.::|..:.:.....|.:.|||||:||.:...:.|:..|:|.|.|:.|.||.:.|::
Human  1476 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	304/1326 (23%)
		ABC_membrane	<147..333	CDD:279056	26/194 (13%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	78/243 (32%)
		ABC_membrane	749..1019	CDD:279056	58/298 (19%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	80/235 (34%)
ABCC1	XP_016878726.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910