DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and CG4562

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster

Alignment Length:	1430	Identity:	299/1430 - (20%)
Similarity:	567/1430 - (39%)	Gaps:	280/1430 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MTETREDVPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGF-VAAFLQSLV 66
            :.|.|.|...:....|.....:||:.|:|...::..:   ..:.||    .|:|. :..|:..:.
  Fly    49 LQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPSLLKAS---MNVFGW----RLAGLGLVLFILEIG 106

  Fly    67 FPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKI--LTNASYEENMQELRKDSVSFGILM 129
            |.:.                          ..||.||.:  ..:||.:|...:.:....:.|:::
  Fly   107 FRVT--------------------------QPLFLGGLVAYYADASNQEGDNQTKAYLYALGVIL 145

  Fly   130 TLNTLLMLFSGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIR 194
            | :...:||...|.:..|: :.:|..:.|....::..||..                       |
  Fly   146 T-SACNVLFMHPYMLGMFH-IGMKARIAMTSMIYRKALRLS-----------------------R 185

  Fly   195 SGIAE-NLGHYVEIMCDVI----ISVV-LSFIYGWKLALAIVFYIPLTLVVNSA----------- 242
            :.:.: .:|..|.::.:.:    :||: :::::...:.:.|:.|:....:..||
  Fly   186 TALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFI 250

  Fly   243 -VAHYQGKLTGQEQSSYVRASS---------VVEEVIGAIRTVVAFGGERSESLRYDSLLKPALK 297
             :..|.||.|     |.:|..:         ::.|:|..|:.:..:..|...|...:.:....:.
  Fly   251 PLQAYLGKKT-----SVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMN 310

  Fly   298 AGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLIL---------------YYR------DPSIP 341
            |.:......|   |:...::|:|....|......:|               ||.      ....|
  Fly   311 AIRNVNYIRG---TLQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFP 372

  Fly   342 IDEREYTPAVVMI--VISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGK 404
            :...::...:|.|  :.:.::....::...|..|:...:.:....|...|...|.::.|.|:.
  Fly   373 MGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRR-- 435

  Fly   405 ILNYGLKGAVEFRDVFFRYPAREDV----IVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRF 465
                  ....|...|..:..|:.|.    ..|..:::..:..|.||::||.|.|||:.||.:...
  Fly   436 ------TSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGE 494

  Fly   466 YDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAAN 530
            .:|..|.|.::|             .::...|||.||.|::.:||..|.|....:......:.|.
  Fly   495 LNPDSGSVKVNG-------------TLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCAL 546

  Fly   531 AHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAAL 595
            ..||.: |.....|.:.|:|..|||||:.||::|||:.::..|.|||:..||:|.|   :.:...
  Fly   547 ERDFEL-LPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTH---VGRHLF 607

  Fly   596 DKACKG----RTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDS 656
            |:..:|    ...|:|:|:|..:..|..||.::.||....||:|.:.|....:.:|:|..|..|
  Fly   608 DQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKD- 671

  Fly   657 AEELLNELEEVAEIKERKMSYEVEPYQLGTRN-SIVSLEKNAEFQMKNLNGLANITMNQEIDDPR 720
                    |...:..::| |...:..:|..|: ||.|:|..||       .|| .....:..:.|
  Fly   672 --------EGAGDAPDKK-SLSRQNSKLRDRHGSISSMESAAE-------SLA-AESPMQTQEGR 719

  Fly   721 VPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAE------------------ 767
            |.....:..:.:..| |.....|::....|.|         :.|||.
  Fly   720 VEGRIGMKLYKKYFG-ANGYGLFIVFAFFCIG---------AQVLASGGDIFLSYWVNKNGEAER 774

  Fly   768 --LYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCY--IQTFFFNLAGVWLTTRMRSKTFRCI 828
              ....|.:...|..:........|....||...|:.:  :::..|....:..:|.:.:..|:.:
  Fly   775 DTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGV 839

  Fly   829 MNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALIC 893
            ....|.:|:  .|..|.:..|.|.|...|...:...:.:::|.|...:..:.:          :|
  Fly   840 TRAAMHFFN--TNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVV----------LC 892

  Fly   894 LSTSPFMVAS----IVFE-ARFGEKSALKEKEVLEETSRI-----ATETITQIRTVAGLRREEEL 948
            :....:::|:    |||. .|....|..::.:.||..:|.     .:.::..:.|:.....::||
  Fly   893 IINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKEL 957

  Fly   949 IKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGY-----------AVTLTY-------GGHM 995
            |..:|...:.:.         .|....|..| ..|||           .:||::       ||
  Fly   958 IAEFDNYQDMHS---------SGYYMFLATS-RAFGYWLDCVCVVYIAVITLSFFLFSPENGG-- 1010

  Fly   996 CADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQ 1060
              |..:.....|.::..:.:|:...|:       ....:.:..|:.|..|.:|:    ..||.:.
  Fly  1011 --DVGLAITQAMGMTGMVQWGMRQSAE-------LENTMTAVERVVEYEDLEPE----GDFESKP 1062

  Fly  1061 NGNGTAYKTNVVQQG-VSYRGLNFSY-PSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQL 1123
            |...   ..:..:.| :.:..|:..| |.:....||::.|:.|...:.|.:||.:|:|||:.:..
  Fly  1063 NKKP---PKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINA 1124

  Fly  1124 LMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQII 1188
            |.| ...:||.||||:... :|:.|..||.::.|:.|||.||..::..|:...|......:.:.:
  Fly  1125 LFR-LSYNEGAILIDRRDT-NDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESL 1187

  Fly  1189 EAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSE 1253
            |..|:   .:.:..||:...:.:...||..|.||:|.:.:|||::|..:||::||||:.:|.|::
  Fly  1188 EEVKL---KQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTD 1249

  Fly  1254 RVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTK 1318
            .::|..:.:.....|.:.|||||.|:.:::.:.|:.|||.||.||..:||..:  ..|::....|
  Fly  1250 ALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTS--EKKVFHSMVK 1312

Fly 1319 1318
Fly 1313 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	283/1342 (21%)
		ABC_membrane	<147..333	CDD:279056	31/212 (15%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	71/242 (29%)
		ABC_membrane	749..1019	CDD:279056	52/319 (16%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	75/240 (31%)
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	296/1414 (21%)
		ABC_membrane	98..367	CDD:294371	48/327 (15%)
		ABCC_MRP_domain1	443..643	CDD:213217	63/216 (29%)
		ABC_membrane	799..1027	CDD:294371	44/253 (17%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	72/225 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910