Protein Alignment CG10226 and Mrp4

DIOPT Version :9

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_650086.2
• Gene: Mrp4 / 41387
• FlyBaseID: FBgn0263316
• Length: 1316
• Species: Drosophila melanogaster
• Alignment Length: 1500
• Identity: 325/1500 - (21%)
• Similarity: 582/1500 - (38%)
• Gaps: 416/1500 - (27%)

  Fly     8 EDVPAADADEATPAA------------QKKKKTKEKAQPMVSYTELFRYI-------------AG 47
            :::|....:.::|.:            :.:|||.|:       .:|:|.:             |.
  Fly     7 DELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQ-------KDLYRALKEHKSDSLGDRLCAA 64

  Fly    48 WD---------------------YLVLLSGFVAA--FLQSLVFPIAIVVYSELVAMFI----ERT 85
            ||                     :|.:...|:.|  ||..:..||.::   .::|.|.    :|:
  Fly    65 WDEQVAKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLI---GVMAYFAGNDPDRS 126

  Fly    86 LGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRL 150
            ..|..::..|..|:|                     ||..|....|.   :|..|:....|.:.|
  Fly   127 KAQLWAAGLIAGSVF---------------------SVCIGHPYMLG---LLHLGMKMRIALSSL 167

  Fly   151 ALKLTVRMRREFFKAT--------LRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEI 207
            ..:..:|:.|.....|        |..::|..|:                    :..|: ||:.|
  Fly   168 IYRKALRLSRTALGDTTVGQVVNLLSNDVGRFDL--------------------VLINV-HYLWI 211

  Fly   208 MCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASS--------- 263
            ....:|:|  :::...::.::.:|.:.:.|:. .....|.||.|     |.:|..:
  Fly   212 APLELIAV--TYLMYLEIGISSMFGVAIMLLF-LPFQSYLGKRT-----SVLRLRTALRTDERVR 268

  Fly   264 VVEEVIGAIRTVVAFGGERS-----ESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAG 323
            ::.|:|..|:.:..:..|:.     |..|::.:|                   .:|.:.:|.|.
  Fly   269 MMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEML-------------------CIKQVNYIRGI- 313

  Fly   324 SFWYGANLILYYRDPSIPIDEREYT-PAVVMIVISGIIVSA----------NQISRT-------- 369
                   ||.:....|     |.:| .:::..|:.|.|::|          |.:.|:
  Fly   314 -------LISFAMFLS-----RIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQG 366

  Fly   370 -SPFLETFAMARGSASAI----LDVIDRTSLIDPLSKAGKILNYGLKG------AVEFRDVFFRY 423
             |.|.|.....|...:.:    ..|.|::.:.:...||........||      .:||.....|:
  Fly   367 ISEFAELLVSVRRLEAFMHRPETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARW 431

  Fly   424 PAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWL 488
            .:......|..:|:.:...:.||::||.|.|||:.||       .:.|::..:...:|      :
  Fly   432 ESHSLEPTLEDINLQLGRRKLVAVIGPVGAGKSSLIQ-------AILGELPGESGTLR------I 483

  Fly   489 RSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQL 553
            ..:.:...|||.||.|::.:||..|......:......|.|...||.: |..|..|.:.|:|..|
  Fly   484 NGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYRTVVKKCALERDFEL-LPFGDKTIVGERGASL 547

  Fly   554 SGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKG--RTTLV--VSHRLSAI 614
            ||||:.||::|||:.::..|.|||:..||:|.|   :.:...|:..:|  |:.||  |:|:|..:
  Fly   548 SGGQKARISLARAVYRRADIYLLDDPLSAVDTH---VGRHLFDQCMRGYLRSELVILVTHQLQFL 609

  Fly   615 RHAHRIVYIENGKAVEQGTHEELMKLEGF-YHKMVTVHSYDDSAEELLNELE----------EVA 668
            ..|..||.::.|:....||:.. ||..|. :.:::|..:.|  ||: |:|::          .|.
  Fly   610 EQADLIVIMDKGRISAMGTYSS-MKRSGLDFAQLLTAPNKD--AED-LDEIDGAGGDGLDLLNVP 670

  Fly   669 EIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQE----IDDPRVPSANFIST 729
            .:..|           |::||..|...|:   ..:|:.:|. :|.||    :.:.||.
  Fly   671 SLSRR-----------GSKNSKPSTRNNS---FTSLSSMAE-SMAQEASLQMQETRVE------- 713

  Fly   730 FFRILGWARPEWSFLIIGAICAGLYG-----------VTMPVFSVVLAELYGSLAK--------- 774
                             |.|..|||.           :...||..:..::..|.|.
  Fly   714 -----------------GKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDK 761

  Fly   775 --------PTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQ 831
                    .||.:.:...|:       :.:|..|...::|..|....:..:|::.:..::.|...
  Fly   762 NVDGQTDINTDPQDMYYFAA-------LNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRA 819

  Fly   832 EMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLST 896
            .|.:|:  .|..|.:..|.|.|...:...:...:.:::|.|...:..|.:          ||: |
  Fly   820 AMYFFN--TNPSGRILNRFSKDLGQLDEVLPSVMLDVVQLFLTLLGIIVV----------ICI-T 871

  Fly   897 SPF-----MVASIVFE--ARFGEKSALKEKEVLEETSRI-----ATETITQIRTVAGLRREEELI 949
            :|:     :..:|:|.  ..|..|:: ::.:.||..:|.     .:.|||.:.|:..|..::|||
  Fly   872 NPYYLILTLALAIIFYYIREFYLKTS-RDVKRLEAVARSPIYSHLSATITGLPTIRALGAQKELI 935

  Fly   950 KIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTML 1014
            ..:|.         |..|...|....|..: ..|||     |....|.     ...::.|.|..:
  Fly   936 AEFDN---------LQDLHSSGYYTFLATN-RAFGY-----YLDCFCT-----LYIVIIILNYFI 980

  Fly  1015 --------YGLFILAQSLAFTPAFNAALLSA----NRM--------YEIID----------RKPQ 1049
                    .||.| .|::..|.....|:..:    |.|        |:.|:          :||.
  Fly   981 NPPQSPGEVGLAI-TQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEFDSREGKKPS 1044

  Fly  1050 IQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIK-VLQNFNLDINQGQTVALVGAS 1113
            ...||             |..::.:.:..|     |...|..| ||:..|..|...:.|.:||.:
  Fly  1045 PSWPE-------------KGEIIAEDLCLR-----YFPDPQAKYVLKALNFRIRPCEKVGIVGRT 1091

  Fly  1114 GSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDT 1178
            |:|||:.:..|.| ...:||.|.||:... .||.|..||.::.|:.|||.||..|:..|:...:.
  Fly  1092 GAGKSSLINALFR-LSYNEGIITIDERDT-ADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEE 1154

  Fly  1179 SRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDE 1243
            .....:...:|..|:   ...|..||....:.:...|:..|.||:|.:.:|||::|..::|::||
  Fly  1155 YNDAKLWDALEEVKL---KPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDE 1216

  Fly  1244 ATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGI 1308
            ||:.:|.|::.::|..:.|.....|.:.|||||:||.:::.:.|:.||.:||.||..:||..:
  Fly  1217 ATANVDPQTDALIQATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSS-- 1279

  Fly  1309 YSKLY 1313
            .||::
  Fly  1280 ESKIF 1284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	304/1375 (22%)
		ABC_membrane	<147..333	CDD:279056	32/207 (15%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	70/239 (29%)
		ABC_membrane	749..1019	CDD:279056	60/317 (19%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	77/238 (32%)
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	321/1484 (22%)
		ABC_membrane	93..359	CDD:294371	62/353 (18%)
		ABCC_MRP_domain1	422..622	CDD:213217	64/216 (30%)
		ABC_membrane	735..978	CDD:294371	53/283 (19%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	72/230 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910