Protein Alignment CG10226 and abcb5

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_031759158.1
• Gene: abcb5 / 394865
• XenbaseID: XB-GENE-5950198
• Length: 1317
• Species: Xenopus tropicalis
• Alignment Length: 1310
• Identity: 515/1310 - (39%)
• Similarity: 759/1310 - (57%)
• Gaps: 95/1310 - (7%)

  Fly    25 KKKTKEKAQPMVSYTELFRYIAGW-DYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQ 88
            |:..|.|.:.::....:|:: |.| |..:::.|.:.|......:|:..||:.|:...|:......
 Frog    82 KENEKNKQEQIIGPISIFQF-ADWLDIFLMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLCHNSSL 145

  Fly    89 GTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALK 153
            ..||..              |.::...:|::|.|:.:..|    ...:||.|...|..:...|.:
 Frog   146 QNSSAC--------------AKFKPIEEEIQKFSLYYAGL----GFAVLFCGYLQVSCWVVAASR 192

  Fly   154 LTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLS 218
            .|.:||:.||.:.|.|||||.|:.|..:...|:|:|:.||..||.:.:.|:.:.....:..:::.
 Frog   193 QTRKMRKAFFHSVLSQEIGWFDVTKSGDLNTRLTENINKINDGIGDKVAHFFQNTTICVSGILIG 257

  Fly   219 FIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERS 283
            .|.||||||.|:...|:..:.::..:.....||.:|.::|.:|.:|.:||:.:||||||||||..
 Frog   258 LIQGWKLALVILATSPVLTLASAMFSRIVVSLTTKELAAYAKAGAVAQEVLSSIRTVVAFGGEEK 322

  Fly   284 ESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPIDEREYT 348
            |..||...||.|...|..|...|..:..::....:.|....||||..|:|         ::.:||
 Frog   323 EIKRYTENLKQAKDIGIKKSIASQFALGLVNGAFYATYGVGFWYGTTLVL---------EDDDYT 378

  Fly   349 PAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAG-KILNYGLKG 412
            ...||.|...:..|:..|.:.:...|.|.:||.:||:|..||.::|.||..|..| |..|  :||
 Frog   379 IGDVMAVFFNVSFSSYAIGQAASHFEAFHIARAAASSIFKVIKQSSSIDNFSNDGFKPDN--IKG 441

  Fly   413 AVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDG 477
            .:|.:|::|.||:|..|.||.|||:.|:.||||||||.|||||||.:|||||.|||..|.:.:||
 Frog   442 NIELKDIYFSYPSRPGVKVLNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYDPKEGTLAVDG 506

  Fly   478 EDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGY 542
            .|::..|:.:.|..|.||.||||||..:|.:|||:|:.:.|.:|:|.|.|.|||:|||:||...|
 Frog   507 HDIKSLNVTYYRELIGVVSQEPVLFGTTIKQNIRYGRDDVTDEEIEKAVKEANAYDFIMALPDKY 571

  Fly   543 DTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVV 607
            :|.:.|:|.||||||:||||:||||::.||||||||||||||..||.:||||||||.|||||:||
 Frog   572 ETLVGERGAQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGSEAVVQAALDKARKGRTTIVV 636

  Fly   608 SHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKE 672
            :||||.|..|..||.|:||...|||||.|||:.:|.|..:.|..:..      |::..|..|..:
 Frog   637 AHRLSTIWTADVIVVIDNGAVAEQGTHSELMEKKGIYFSLATAQTVQ------LSDDNETTEKNQ 695

  Fly   673 RKMSYE----VEPY--QLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFF 731
            ..:.||    ::.:  |...::.|:..|...|...|:|              |.|       :||
 Frog   696 NGIIYEKASLIQRFNSQTSLKSKILEDEDEEEESKKDL--------------PTV-------SFF 739

  Fly   732 RILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGI 796
            ::|...|.||.::::|.|.||:.|..:|:|.:..|.:....|....|.:.::|   .:.||:.|:
 Frog   740 QLLKLNRSEWPYILLGIIAAGVIGSLLPLFCIFYARIIAVFASNDPETIRKES---DLCSLIFGL 801

  Fly   797 AAGVV--CYI-QTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQ 858
            ...|:  .|| :.:.|..:|..||.|:|...|:.::.|::.|||.|:|:.|||:.||:.||:.:|
 Frog   802 TGVVILLAYIARGYMFGRSGETLTMRLRHMAFKAMIQQDIAWFDDKDNNTGALTTRLATDASEIQ 866

  Fly   859 GAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMV--ASIVFEARFGEKSALKEKEV 921
            .|.|:.|..:.:.....:.::.|||.|.|||||:.|:.:||||  ..:.|.|..|  .|.::|:.
 Frog   867 TATGYRLGFLAENLIGIVLTVIIAFVYGWELALLGLAMAPFMVICGLLEFSALTG--FATRDKKQ 929

  Fly   922 LEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYA 986
            |:...:||||.:..|||:..|.||....::|.:.:::.....|.:.:..||..::|.:..:|.:|
 Frog   930 LQRAGKIATEAVDNIRTLVSLTRERTFEEMYSESLQKPYRNSLRKAQIYGLYFAIGHAFYYFTHA 994

  Fly   987 VTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQ 1051
            ....:|.::....:|..|..:.:.:.:.:|...|..:|.|.|.:..|..:|..::.:.:.||.|.
 Frog   995 ALFCFGAYLIKYERINVEEALLVFSVITFGAMTLGTTLTFAPDYAKATSAARYLFALFESKPAID 1059

  Fly  1052 SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSG 1116
            |.     .|.|.    |.:.....:.:|.::|:||:|..::||::..:.:..|||||.||:||.|
 Frog  1060 SS-----SQQGQ----KPDCFSGSLEFRNVSFNYPTRSDVRVLRDLCVKVESGQTVAFVGSSGCG 1115

  Fly  1117 KSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKT-----LRRRLGIVSQEPSLFEKSIADNIGYG 1176
            |||.||||.|:|||.||::|:|      |:|.|.     ||.::|||||||.||:.|||:||.||
 Frog  1116 KSTSVQLLQRFYDPKEGEVLLD------DVDAKCFNVQWLRSQMGIVSQEPVLFDCSIAENIAYG 1174

  Fly  1177 DTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLL 1241
            |.||.|.|.:|..|||.||.|.||..||.:|:|::|:||||||||||||||||||::|.||||||
 Frog  1175 DNSRTVSMDEIQSAAKAANIHSFIEGLPLKYETLVGAKGTQLSGGQKQRIAIARALIRAPKILLL 1239

  Fly  1242 DEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKN 1306
            ||||||||.:||:|||||||.|..|||||:|||||:|:|||::|.|:..|||:|.|||.:||||.
 Frog  1240 DEATSALDNESEKVVQQALDQARKGRTCILIAHRLTTVQNADIIVVMNKGKIIEHGSHQELLAKC 1304

  Fly  1307 GIYSKLYRCQ 1316
            |.|..|...|
 Frog  1305 GAYYDLVNAQ 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	230/505 (46%)
		MdlB	723..1320	CDD:440747	247/604 (41%)
abcb5	XP_031759158.1	PTZ00265	164..1311	CDD:240339	494/1208 (41%)