DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10226 and tap2a

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001006594.1	Gene:	tap2a / 368771	ZFINID:	ZDB-GENE-030616-245	Length:	725	Species:	Danio rerio

Alignment Length:	704	Identity:	233/704 - (33%)
Similarity:	352/704 - (50%)	Gaps:	133/704 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTMTETREDVPAADADEATPAAQKKKKTKEKAQPM-VSYTELFRYIAGWDYLVLLSGFVAAFLQS 64
            :|:.:|.|:             ...|:.|:||:.: :....|:|.    ||::|...||  ||
Zfish   117 ITLPDTNEE-------------SNGKERKQKARVLFIRVIRLYRP----DYILLFGAFV--FL-- 160

  Fly    65 LVFPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKI-LTNASYE-ENMQELRKDSVSFGI 127
                 |:.|..|   |||               .|:.|..| :..:.|: :|.:       |..|
Zfish   161 -----ALAVLCE---MFI---------------PLYTGEVIDILGSHYQWDNFR-------SAII 195

  Fly   128 LMTLNTLLMLFS----GVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITD 188
            .|.|.:|...||    |..::.|.|    ..|.|::.:.|.:.:||:||:.:..|..:...|::.
Zfish   196 FMGLFSLGSSFSAGCRGGLFMCAIN----SFTCRVKVQLFGSLIRQDIGFFETIKTGDITSRLST 256

  Fly   189 NMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLT-LVVNSAVAHYQGKLTG 252
            :...:...:|.|:...:..:...:..:.|.....|||.|.::...||| |:.|....||| ||:.
Zfish   257 DTTLMGRAVALNVNVLLRTLVKTLGMLYLMVSLSWKLTLLMLMETPLTGLLQNIYDTHYQ-KLSK 320

  Fly   253 QEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPA--LKAGKWKGAFSGLSDTV--- 312
            :.|.|..:|:....|.:..||||.:|..|..|:.|||..|...  ||..:         |||
Zfish   321 EVQDSMAQANDAAGEAVSGIRTVKSFKTELGEAHRYDGRLMETHNLKTRR---------DTVRAI 376

  Fly   313 -----------MKAMLFITGAGSFWYG-------ANLILYYRDPSIPIDEREYTPAVVMIVISGI 359
                       ||..:...|.....||       .:.|||.:|....|.        .:|.|.|.
Zfish   377 YLLIRRMTELGMKVAMLYYGRLFIQYGQMSTGNLVSFILYQQDLGDNIR--------TLIYIFGD 433

  Fly   360 IVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYP 424
            ::  |.:              |:|..:.:..||.|   .:|..|.::...|||.|:|:.:.|.||
Zfish   434 ML--NSV--------------GAAGKVFEYQDRKS---EVSIDGNLMPKDLKGHVKFQKLTFSYP 479

  Fly   425 AREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLR 489
            .|.|..||:..::.::.||..||||.||.|||||:.||:|||.|..|.:||||:.::.|..|:|.
Zfish   480 RRPDHNVLKDFSLELKPGQITALVGMSGGGKSTCVSLLERFYQPQQGTILLDGKPLQDYQHKYLH 544

  Fly   490 SNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLS 554
            |.:|:||||||||.|::.:||.:|....:.:.|::||..||||.||..|.||||||:.|:|..||
Zfish   545 SKVAMVGQEPVLFSGTVRDNIAYGLQGCSMERVKEAASKANAHSFISKLEKGYDTDVGERGNLLS 609

  Fly   555 GGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHR 619
            ||::||||||||||::|::|:|||.||:||..||::||.|| ..|..:|.||::|||..|..|.:
Zfish   610 GGEKQRIAIARALIREPQVLILDEVTSSLDTESEQMVQQAL-SCCPTQTLLVIAHRLKTIERADQ 673

  Fly   620 IVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKER 673
            ||.|::|:.||:|||||||:.:|.|:|:         .|.|.::.:...:.||:
Zfish   674 IVVIDSGELVEKGTHEELMEKKGSYYKL---------RERLFSDDKTTKQEKEK 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	213/623 (34%)
		ABC_membrane	<147..333	CDD:279056	52/209 (25%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	122/234 (52%)
		ABC_membrane	749..1019	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216
tap2a	NP_001006594.1	MdlB	136..708	CDD:224055	224/660 (34%)
		ABC_membrane	157..417	CDD:279056	78/307 (25%)
		ABCC_TAP	458..682	CDD:213215	114/224 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910