Protein Alignment CG10226 and Mdr50

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Alignment Length: 1341
• Identity: 517/1341 - (38%)
• Similarity: 763/1341 - (56%)
• Gaps: 115/1341 - (8%)

  Fly    13 ADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSEL 77
            :||.:....:|..:..|:     |||.:||||....|..:.:.|.::|....|..|...:::..|
  Fly    53 SDASDEEDGSQYHEDVKQ-----VSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIFGNL 112

  Fly    78 VAMFIERTLGQGTSSVTIGLSLFGGGKILTNASY--EENMQELRKDSV-SFGILMTLNTLLMLFS 139
            ....|:.                 ||.:.:..||  ::.:..|..|.| .|.:..|...::||..
  Fly   113 ANDMIDL-----------------GGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIMLVC 160

  Fly   140 GVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHY 204
            ....:..||..|....:.:|.:||::.|.|::.|:|..:....|.|:.:::.|:..|:||.:..:
  Fly   161 SYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVVMF 225

  Fly   205 VEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVI 269
            |..:...:.|:||:|:.||:|:|..:..:|||.:....||....:|..:|.:.|..|:.|.|..:
  Fly   226 VHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEGAL 290

  Fly   270 GAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILY 334
            ..||||.||.||..|...|...:..|......:..|||:...::...::.:.|.:||||..|::.
  Fly   291 SGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLVIK 355

  Fly   335 -YRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDP 398
             |.:|:.    ..|....::.|...:::.:..|...:|::|.|.:|:|:.:.:..:|::...|:|
  Fly   356 GYHEPAY----ENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINP 416

  Fly   399 LSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQ 463
            :...||.||..|. .:||::|.|:||.|.:|.:|..||:.:..||||||||||||||||||||:|
  Fly   417 IDGEGKKLNEPLT-TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQ 480

  Fly   464 RFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKA 528
            |||||..|.:|.:|.:::..:|.||||.|.||||||:||..||.||||:|:.:||::|:|.||.|
  Fly   481 RFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAA 545

  Fly   529 ANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQA 593
            |||..||..|.|||||.:.|:|.||||||:||||||||||:.|:||||||||||||..||..|||
  Fly   546 ANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQA 610

  Fly   594 ALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAE 658
            ||:|...||||::|:||||.:|.|.|||.|..|:.||.|||:|||:|:..|..:||....:|...
  Fly   611 ALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVTTQLGEDDGS 675

  Fly   659 EL--LNELEEVAEIK-----ERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEI 716
            .|  ..::.:..:||     |.|:..|.|     ..:.:|:.|||.:.:.|            ::
  Fly   676 VLSPTGDIYKNFDIKDEDEEEIKVLSEDE-----DEDVMVTDEKNKKKKKK------------KV 723

  Fly   717 DDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSL-----AKPT 776
            .||     |.:.....::...:|||..:.:|.|.:.:.|..||:|:|    |:||:     .|..
  Fly   724 KDP-----NEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAV----LFGSILQILSVKDN 779

  Fly   777 DEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKEN 841
            |:.|.|.|...::..|:.||..|:..::|.:||.:||..||.|:|...|..::.||:.|||.|.|
  Fly   780 DQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKAN 844

  Fly   842 SIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVF 906
            ..|:|.||||||||:||||.|..:..|:|:.:.....||::..|.|.|.|:.|:.:||::.:...
  Fly   845 GTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYM 909

  Fly   907 EARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIY------DKEV-ERYRHQIL 964
            :.....|..:...:.:|..:::|.|.::.|||||.|.|||...:.|      ..|: :|..|
  Fly   910 QRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTH--- 971

  Fly   965 SRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPA 1029
                :||||..|.:|||||.||..:.||........|.|..:.|:|..::.|...:|.:|||.|.
  Fly   972 ----FRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPN 1032

  Fly  1030 FNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVS-----------YRGLNF 1083
            ....:.:|..::..:.|:|.|                    |.:.|||           :..:.|
  Fly  1033 MQKGVSAAKTIFTFLRRQPSI--------------------VDRPGVSRDPWHSEGYVRFDKVKF 1077

  Fly  1084 SYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDL 1148
            |||:|..|:||:...|.:::||.:||||.||.|||||:||:.|:||.|||..|||:..: .::.:
  Fly  1078 SYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDV-RNVSM 1141

  Fly  1149 KTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGS 1213
            ..||.:||||||||.||:::|.:||.|||.:|.|..|:||.|.|.:|.||||.:||..|||.:|.
  Fly  1142 TNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGE 1206

  Fly  1214 KGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLST 1278
            ||.|||||||||||||||::|||||:||||||||||.:||:|||.|||:|..|||.|.|||||||
  Fly  1207 KGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLST 1271

  Fly  1279 IQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTKA 1319
            :.:::||.|.:.|.:.|.|.|.||||..|:|..||:.|:.|
  Fly  1272 VVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTLYKLQSGA 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	220/505 (44%)
		MdlB	723..1320	CDD:440747	253/620 (41%)
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	512/1319 (39%)