Protein Alignment CG10226 and Mdr49

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Alignment Length: 1309
• Identity: 564/1309 - (43%)
• Similarity: 822/1309 - (62%)
• Gaps: 41/1309 - (3%)

  Fly    23 QKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLG 87
            |.|:.:...|....||.:||||....:..:|:...:.|...|...|..:::|.|..::.::||:|
  Fly    16 QLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVG 80

  Fly    88 QGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLAL 152
            .||||....|.:||||:.|||||.|||.|.:..|:.:|||...:.::.|.......:|..||:||
  Fly    81 VGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIAL 145

  Fly   153 KLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVL 217
            ....|:|:.|.:|.|||:|.|:|.:...|||.::|::::|::.||.|.:...|.::...:|.:|.
  Fly   146 NQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVS 210

  Fly   218 SFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGER 282
            :|:|||||.|.::..:|..:...|.||..||.|..:|..||..|::|||||...||||.||.|:.
  Fly   211 AFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQE 275

  Fly   283 SESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPIDEREY 347
            .|..|:..||.||...|:.||.:||:.:.:...::::..|.:.|||..|||..||    :.:|.|
  Fly   276 KEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERD----LPDRVY 336

  Fly   348 TPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKG 412
            ||||::||:..:|:.|..:...||.:|..|:|..:...:.::|||.|.:||:.:.|. ......|
  Fly   337 TPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN-RPENTAG 400

  Fly   413 AVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDG 477
            .:.|..:.||||||.||.:|:||.|.|..|||||.||.|||||||.|||:||||||..|.|.|||
  Fly   401 HIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDG 465

  Fly   478 EDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGY 542
            .|:|..|:.||||.|.|||||||||..:||||||:|:|.|||.::|.||:|||.||||..|.|||
  Fly   466 RDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGY 530

  Fly   543 DTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVV 607
            ||.:.|||.|:||||:|||||||||::||::|||||||||||..|||.||:||:.|.:|.|||||
  Fly   531 DTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVV 595

  Fly   608 SHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAE------------EL 660
            :||||.|.:|.:||::::|...|||||||||:..|.|.::|::....::.|            :.
  Fly   596 AHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKS 660

  Fly   661 LNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSAN 725
            .|..:|..:..|.....:.|| :|.|..|    .:::.|:........:....::.|...|...:
  Fly   661 QNLSDEETDDDEEDEEEDEEP-ELQTSGS----SRDSGFRASTRRKRRSQRRKKKKDKEVVSKVS 720

  Fly   726 FISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAII 790
            |.    :::....|||.|:::|.|.:.::|.|.|::.:...:.:|.|:...|:.|..:...:::|
  Fly   721 FT----QLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMI 781

  Fly   791 SLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAA 855
            .:.||:.||:...:||:.|..|||.:|||:|.:.|..|:.|::.:||.:.||:|||.:||:.|.:
  Fly   782 FVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCS 846

  Fly   856 SVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKE 920
            :||||.|..:..::||....:..:.:.|.:||:..|:.|.|.|.:..|:..|.||..|||.|.|.
  Fly   847 NVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKA 911

  Fly   921 VLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGY 985
            .:||.|::|.|.||.||||.||..|.:::..|.::::|.......::::||||.:||::..|..|
  Fly   912 SIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAY 976

  Fly   986 AVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQI 1050
            .:::.|||.:.|:.::.:|.|:|::..:::|.::|.|:||:.|..|.|:|||.|:.::..|.
  Fly   977 GISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRT--- 1038

  Fly  1051 QSPESFEIQQNGNGTAYKTNVVQQG-VSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASG 1114
                  ..|.|...:.|.|....:| :.|..:.|.||:|....:||..||.|.:..||||||.||
  Fly  1039 ------STQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSG 1097

  Fly  1115 SGKSTCVQLLMRYYDPDEGKI-LIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDT 1178
            ||||||||||:|||||..|.: |....|....:|  |||.:||:|||||.||:::||:||.||:.
  Fly  1098 SGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLD--TLRSKLGLVSQEPVLFDRTIAENIAYGNN 1160

  Fly  1179 SR-QVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLD 1242
            .| .|.||:||||||.:|.|.||.:||..|||.|| |.:|||||||||||||||:|||||||:||
  Fly  1161 FRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILD 1224

  Fly  1243 EATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNG 1307
            |||||||.:||:|||||||.|.|||||:.|||||:|::||::|||::.|.:||.|:|.:|:|.|.
  Fly  1225 EATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNK 1289

  Fly  1308 IYSKLYRCQ 1316
            ||:.||..|
  Fly  1290 IYANLYLMQ 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	249/504 (49%)
		MdlB	723..1320	CDD:440747	261/597 (44%)
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	282/603 (47%)
		MdlB	720..1299	CDD:440747	261/595 (44%)