DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and Sur

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001334732.1	Gene:	Sur / 34350	FlyBaseID:	FBgn0028675	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	1877	Identity:	360/1877 - (19%)
Similarity:	615/1877 - (32%)	Gaps:	692/1877 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TETREDVPAADADEATPAAQKKKKTKEKAQPMVSY---------TELFRYIAGWDYLVLLSGFVA 59
            :.|.::....|...|||     :.....::|.:|:         ||..|.|..: :|::
  Fly   452 SSTSDEKQKNDDSMATP-----EHVDNPSEPNISHDIGSITNHMTEDTRNIMEF-FLII------ 504

  Fly    60 AFLQSLVFPIAIVVYSELVAMFIERTLGQGTSSVTI-GLSLFGGGKILTNASY-----EENMQEL 118
            .:..::.|.||:|:|...:.:.|...:|.....|.: .|..|.|..:..||..     :|.::.:
  Fly   505 HYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRI 569

  Fly   119 RKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFA 183
            ....|...::.              ::|::.:.||.....||:..|...:....|..||...:.|
  Fly   570 HDTLVGIKVIK--------------LNAWDEVFLKKIQEARRKELKYLNKDATFWTLMAVLTHIA 620

  Fly   184 -VRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQ 247
             |.||          ...||.||.:..|....:..|.::. .|||.....:||.:...:......
  Fly   621 TVLIT----------FVTLGVYVWLHRDQEFDLNASRLFS-SLALFQQLTVPLLIFPITVPIIIA 674

  Fly   248 GKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESL-RYDSLLKPALKAGKWKGAFSGLSDT 311
            .:::.:....::::|.:.::..| ||.:.....:...|| .|::..|               |:.
  Fly   675 ARVSTRRLERFLKSSEIQKQFEG-IRNMARILSKSDASLDMYETQEK---------------SNM 723

  Fly   312 VMKAMLFITGAGSFWYGANLILYYRDP-----SIPI------DEREYTPAVVM-IVISGIIVSAN 364
            .|:.    ..|.:......|....:.|     |.|:      ...:.:|:.|. :..:.::....
  Fly   724 TMRT----AQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRR 784

  Fly   365 QISRTSPFLETF-AMARGSASAILDVIDRT---SLI-----DPLSKAGKILNYGLKGAVEFRDVF 420
            ::.|.:|::... ...|||      |::|.   |:|     |...:...:|......||...|..
  Fly   785 ELLRNTPYVAIRPPKMRGS------VMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGL 843

  Fly   421 FRYPARED--VIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKY 483
            |.:..:..  |:.|....::|.:|:...:||.:|.||::.:..|      :....||.|
  Fly   844 FTWQPQSQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSAL------LMEMPLLAG------ 896

  Fly   484 NIKWLRS-NIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFII----------A 537
            |:.|.:: .|:.|.|:|.|...:|.|||..|:....::           :||::          .
  Fly   897 NMFWHKTCTISYVSQQPWLLNDTIRENILFGESFRPKR-----------YDFVLEACALKPDIEL 950

  Fly   538 LHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALD-----YHSEKLVQAALDK 597
            :.:|..:.|.|:|:.:|||||||||||||:.....::::|:..::||     :..:..::..|.|
  Fly   951 MPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQK 1015

  Fly   598 ACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHE--ELM---------------------- 638
            :  .||.::|:.:|..|:.|..::.|::|:....|::.  |||
  Fly  1016 S--NRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYADIELMQPRITAEWNAIIAMAKAKNDNP 1078

  Fly   639 ------KLEGFYHKM--------------------VTVH--SYDDS-----AEELLNELEEVAEI 670
                  |..|...|:                    |..|  :.|.|     |....|.:||..::
  Fly  1079 SQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACHADAIDGSGCISVANMQSNVVEEDDQV 1143

  Fly   671 K---------------ERKMS---------YEV-----------------EPYQLGTRNSIVSLE 694
            .               :||.|         |:|                 ..:.||.|.|
  Fly  1144 SVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDECQGDDVIMRPRRRHTLGRRGS----- 1203

  Fly   695 KNAEFQMKNLNGLANITMNQE-------------------------ID---------DPRVPS-- 723
            :|.. ....|:||:.:|...|                         :|         :|||.|
  Fly  1204 RNTN-SSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAESSVDGGDLATAAPEPRVQSWQ 1267

  Fly   724 -----------------------AN--------------------------FISTFFRILGWARP 739
                                   ||                          ....|.|.:...|.
  Fly  1268 PPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPLDDHVRGSFQQFLRRMSMRRS 1332

  Fly   740 EW------------SFLIIG-----------------------------AICAGLYGVTMPV--- 760
            ..            |.|.|.                             ..|..:......:
  Fly  1333 NKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQSEEKPKKCVNIDSKETTINCD 1397

  Fly   761 ---FSVVLAELYGSL-AKPTDEE------VLEQSA------SMAIISLVIGI------------- 796
               :|....||..:: :.|.|:|      ||.:.|      ||.:..|.|..
  Fly  1398 DNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPLARLAIDTERKYGKISDDIYL 1462

  Fly   797 ----AAGVVCYIQTFFFNLAGVW----------------LTTRMRSKTFRCI----MNQEMGWFD 837
                |||:.  |.|.||..|.:|                :..|:.||....:    .:.|:.::.
  Fly  1463 MYIRAAGLP--IITIFFITALIWQCLRVYTDIWLQQWSNVHGRVASKGHVVLHPSEQDHEVTYYF 1525

  Fly   838 RKENSIGA---LSARLSGDAASVQG------------------AIGF----PLSNIIQAFTNFIC 877
            |...:|..   :.|.:|..|....|                  .:.|    ||..|:..|:|.:.
  Fly  1526 RMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMA 1590

  Fly   878 ----SIAIAFPYSWELALICLS---------------TSPFMVASIVFEARFGEKSALKEKEVLE 923
                .||.......:..|:|||               |.|...|..:.: :|...|| :|.:.:|
  Fly  1591 VIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPICGAYYLIQ-KFYRCSA-RELQRIE 1653

  Fly   924 ETSRI-----ATETITQIRTVAGLRREEELIKIYDKEVE--RYRHQILSRL-KWRGL-VNSLGKS 979
            ..:..     .:|||..:.|:....::....:|..|.:|  ...:.:|:.. :|.|: ::.||..
  Fly  1654 NATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAYALLNTSHRWLGVSLDYLGGC 1718

  Fly   980 LMFFGYAVTLTYGGHMC------------ADGKIKFETI-----------------MKISNTMLY 1015
            ::|......||.....|            :.....|||.                 :.|:.|:|.
  Fly  1719 IVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSPSELRPSPSLVGLAINYTLLV 1783

  Fly  1016 GLFILAQSLAFTPAFNAALLSANRMY-----------------------------EIIDRKPQIQ 1051
            .:::         .:...||:...||                             ..:|.:|...
  Fly  1784 PIYL---------NWVVKLLADMEMYAGSVERIAHYAQGQDADADADADADADVDADLDHEPSSN 1839

  Fly  1052 SPESFEIQQN------------------------------------------------------- 1061
            ...|.|:.::
  Fly  1840 EDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGYRQGHENGAEANADK 1904

  Fly  1062 ---GNGT----------------------AYKTNVV-------QQG----------------VSY 1078
               ||.|                      ..||:|:       ||.                ..|
  Fly  1905 LNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKKVVLPNEPARKLERY 1969

  Fly  1079 RGLNFSYPSRPHI--------------KVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYD 1129
            :.:..|:|.|..|              .|:.|..|.|..||.:.:.|.:|||||:....|.....
  Fly  1970 QSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICGRTGSGKSSLGLSLFGVLQ 2034

  Fly  1130 PDEGKILIDQESIHHDMDLK-----TLRRRLGIVSQEPSLFEKSIADNI---GYGDTSRQVPMQQ 1186
            ...|.|.||      |:|::     .||.||.|:.|:..||..:|.:|:   ||...      .|
  Fly  2035 TTRGHIYID------DVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYFQD------LQ 2087

  Fly  1187 IIEAAKMANAHEFIMS-LPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDF 1250
            :....::|...||:.. ||...|||:...|..||.|.:|.:.:|||::|....|:||||||.||.
  Fly  2088 LWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATSVLDS 2152

  Fly  1251 QSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNG 1307
            .:|..:.:|.|.|..|||.|.|||||:||.:.:.:.|:..|:|||.|:..:|....|
  Fly  2153 STESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRELQQLEG 2209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	343/1791 (19%)
		ABC_membrane	<147..333	CDD:279056	35/187 (19%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	67/302 (22%)
		ABC_membrane	749..1019	CDD:279056	75/407 (18%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	86/255 (34%)
Sur	NP_001334732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910