DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB5

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	1317	Identity:	487/1317 - (36%)
Similarity:	740/1317 - (56%)	Gaps:	102/1317 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTL 86
            |:::.|.:::|   |...|:||:..|.|..:::.|.:|:.:.....|:..:|..|:
Human    20 AEEQPKLRKEA---VGSIEIFRFADGLDITLMILGILASLVNGACLPLMPLVLGEM--------- 72

  Fly    87 GQGTSSVTIGLSLFGGGKILTNASYEEN----MQELRKDSVSFGILMTLNTL-------LMLFSG 140
                     ..:|..|..:.||.:..:|    .::|.:|       |||.||       ..|..|
Human    73 ---------SDNLISGCLVQTNTTNYQNCTQSQEKLNED-------MTLLTLYYVGIGVAALIFG 121

  Fly   141 VYYVDAFNRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYV 205
            ...:..:...|.:.|.|:|::||.:.|.|:|||.|.........|:||:::||..||.:.:....
Human   122 YIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKIALLF 186

  Fly   206 EIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIG 270
            :.|....|.:.:..:.||||.|..:...||.:...:|.:.....||.:|.|:|.:|.:|.|||:.
Human   187 QNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYSKAGAVAEEVLS 251

  Fly   271 AIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFI---TGAGSFWYGANLI 332
            :||||:||..:..|..||...||.|...|..:...|.:|   :.|:.|.   |...:||||.:||
Human   252 SIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRTIASKVS---LGAVYFFMNGTYGLAFWYGTSLI 313

  Fly   333 LYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLID 397
            |.        .|..||...|:.|...:|.|:..|....|..||||:|||:|..|..|||:...||
Human   314 LN--------GEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSID 370

  Fly   398 PLSKAGKILNY---GLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCI 459
            ..|.||    |   .::|.|||::|.|.||:|..:.:|:|||:.::.|:||||||.:|.||||.:
Human   371 NFSTAG----YKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVV 431

  Fly   460 QLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVED 524
            |||||.|||..|.:::|..|:|..|::..|.:|.||.||||||..:|..||::|:.:.|.:|:|.
Human   432 QLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMER 496

  Fly   525 AAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEK 589
            ||:.|||:|||:.....::|.:.|||.|:||||:|||||||||::.||||:|||||||||..|:.
Human   497 AAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKS 561

  Fly   590 LVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYD 654
            .|||||:||.|||||:||:||||.||.|..||.:::|...|:|.|.|||...|.|:.:|......
Human   562 AVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIK 626

  Fly   655 DSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDP 719
            .:.|::            ..|:|..|     .:.:.:.|......:...::.....|.::||..|
Human   627 KADEQM------------ESMTYSTE-----RKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLP 674

  Fly   720 RVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAE---LYGSLAKPTDEEVL 781
            .|       :..:||...:|||.|:::|.:.:.|.|...||||::.|:   ::|:    .|:..|
Human   675 EV-------SLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGN----NDKTTL 728

  Fly   782 EQSASM-AIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGA 845
            :..|.: ::|.:::|:...|..::|..|:..||..||.|:|...|:.::.|::.|||.||||.|.
Human   729 KHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGG 793

  Fly   846 LSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARF 910
            |:..|:.|.|.:|||.|..:..:.|..||...|:.|:|.|.||:..:.||.:|.:..:.:.|...
Human   794 LTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAA 858

  Fly   911 GEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNS 975
            ....|.|:|:.|:...:||||.:..|||:..|.||:...::|::.::........:.:..|...:
Human   859 MTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYA 923

  Fly   976 LGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRM 1040
            ...:.::|.||....:|.::...|::..|.:..:...:.||...:.::|...|.::.|...|..:
Human   924 FSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHL 988

  Fly  1041 YEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQ 1105
            :.::::||.|.|.     .|.|.    |.:..:..:.:|.::|.||.||.:.:|:..:|.|.:|:
Human   989 FALLEKKPNIDSR-----SQEGK----KPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGK 1044

  Fly  1106 TVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIA 1170
            |||.||:||.||||.||||.|.|||.:|::|.|.... .:::::.||.::.||.|||.||..|||
Human  1045 TVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDA-KELNVQWLRSQIAIVPQEPVLFNCSIA 1108

  Fly  1171 DNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRN 1235
            :||.|||.||.||:.:|.|||..||.|.||..||.:|:|.:|.||.|||||||||:|||||:::.
Human  1109 ENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQK 1173

  Fly  1236 PKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHS 1300
            ||||||||||||||..||:|||.|||.|.:||||:|:.||||.||||::|.|:..|||.|||:|.
Human  1174 PKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQ 1238

  Fly  1301 QLLAKNGIYSKLYRCQT 1317
            :||....||.||...|:
Human  1239 ELLRNRDIYFKLVNAQS 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	470/1250 (38%)
		ABC_membrane	<147..333	CDD:279056	62/188 (33%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	126/234 (54%)
		ABC_membrane	749..1019	CDD:279056	77/273 (28%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	134/239 (56%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		1/3 (33%)
		PTZ00265	8..1251	CDD:240339	485/1311 (37%)
		ABC_membrane	52..333	CDD:279056	87/316 (28%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	127/236 (54%)
		ABC_membrane	696..962	CDD:279056	75/269 (28%)
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216	134/238 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2881
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.730