Protein Alignment CG10226 and Abcb5

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: XP_006240775.1
• Gene: Abcb5 / 314537
• RGDID: 1566342
• Length: 1255
• Species: Rattus norvegicus
• Alignment Length: 1287
• Identity: 484/1287 - (37%)
• Similarity: 732/1287 - (56%)
• Gaps: 85/1287 - (6%)

  Fly    40 ELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGK 104
            |:||:....|.:::..|.:|:.:.....|:..:|..|:...||...|.|
  Rat    36 EIFRFADNLDIVLMTLGILASMINGATVPLMSLVLGEISDHFINGCLVQ---------------- 84

  Fly   105 ILTNASYEEN----MQELRKDSVSFGILMTLNTL----LMLFSGVYYVDAFNRLALKLTVRMRRE 161
              ||.:..:|    .::|.:|.    |::||..:    ..|..|...:..:...|.:.|.|:|::
  Rat    85 --TNKTKYQNCSQSQEKLNEDI----IMLTLYYVGIGAAALVLGYVQISFWVITAARQTTRIRKQ 143

  Fly   162 FFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLA 226
            ||.:.|.|:|.|.|.........|:..::.|:..||.:.:....:.:....|.:|:|.|..|||:
  Rat   144 FFHSILAQDISWFDGTDICELNTRMNGDISKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLS 208

  Fly   227 LAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSL 291
            |||:...||.:..::..:.....||.:|..:|.:|.:|.||.:.:||||.|||.:..|..||...
  Rat   209 LAILSTSPLIMAASALCSRMVISLTSKELDAYSKAGAVAEEALSSIRTVTAFGAQEKEIQRYTQN 273

  Fly   292 LKPALKAGKWKGAFSGLSDTVMKAMLFITGAG--SFWYGANLILYYRDPSIPIDEREYTPAVVMI 354
            ||.|..||..:...|.||  :.....|:.||.  :||||.:|| :..:|.       ||...::.
  Rat   274 LKDAKDAGIKRAIASKLS--LGAVYFFMNGAYGLAFWYGTSLI-FGGEPG-------YTVGTILA 328

  Fly   355 VISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNY---GLKGAVEF 416
            |...:|.|:..|...:|.||||.:|||:|..|..|||:...||..|.||    |   .::|.:||
  Rat   329 VFFSVIHSSYCIGSVAPHLETFTIARGAAFNIFHVIDKKPNIDNFSTAG----YKPESIEGNIEF 389

  Fly   417 RDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVR 481
            ::|.|.||:|....:|:|.|:.::.|:|||||||||.||:|.:|||||.|||..|.:.:|..|:|
  Rat   390 KNVSFSYPSRPSAKILKGFNLKIKSGETVALVGPSGSGKTTTVQLLQRLYDPEEGCITVDENDIR 454

  Fly   482 KYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDI 546
            ..|::..|..|.||.||||||..:||.||:.|:...:::|:|.||:.|||:|||:|..|.::|.:
  Rat   455 TQNVRHYREQIGVVSQEPVLFGTTIGNNIKFGREGVSEEEMEQAAREANAYDFIMAFPKKFNTLV 519

  Fly   547 SEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRL 611
            .|||.|:||||:|||||||||::.||||:|||||||||..||.||||||:||.||||||||:|||
  Rat   520 GEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQAALEKASKGRTTLVVAHRL 584

  Fly   612 SAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERKMS 676
            |.||.|..||.:::|:.||:|.|.|||..:|.|:.:.           :..::::|.|..|.:..
  Rat   585 STIRGADLIVTMKDGEVVEKGIHAELMAKQGLYYSLA-----------VAQDIKKVDEQMESRTC 638

  Fly   677 YEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFFRILGWARPEW 741
            ........|:..::.|.:.....|.:      ....:|:...|.|       :..:|...::.||
  Rat   639 SAAGNASNGSLCNVNSAKSPCTDQFE------EAVPHQKTTLPEV-------SLLKIFKLSKSEW 690

  Fly   742 SFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASM-AIISLVIGIAAGVVCYIQ 805
            .|:::|.:.:.|.|...|.||::..:|. ::.:..::..|:|.|.: :::.:|:||.|.|...:|
  Rat   691 PFVVLGTLASALNGSVHPAFSIIFGKLV-TMFEDKNKTTLKQDAELYSMMLVVLGIVALVTYLMQ 754

  Fly   806 TFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQ 870
            ..|:..|...|..|:|...|:.::.|:|.|:|.|:||.|||:..|:.|.|.::||....|..|.|
  Rat   755 GLFYGRAEEILAMRLRHSAFKAMLYQDMAWYDEKDNSTGALTTTLAVDVAQIRGAATSRLGIITQ 819

  Fly   871 AFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQ 935
            ..||...||.|:|.|.||:.|:.||.:|.:..:.:.:.......|.|:|:.|:...:||||.:..
  Rat   820 DVTNMSLSILISFVYGWEMTLLILSFAPILAVTGMIQTAAMAGFANKDKQELKRAGKIATEAVEN 884

  Fly   936 IRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGK 1000
            ||||..|.||:....:|::.:.......|.|....|...::..:.:.|.:|....:|.::...|:
  Rat   885 IRTVVSLTREKAFEHMYEETLRTQHRNALKRAHITGSCYAVSHAFVHFAHAAGFRFGAYLIQAGR 949

  Fly  1001 IKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGT 1065
            :..|.:..:...:.||...:.::|.:.|.::.|...|..::.::..||.|.|     ..|||.
  Rat   950 MTPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGAAHLFALLKNKPSIDS-----CSQNGE-- 1007

  Fly  1066 AYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDP 1130
              |.:..:..:.:|.::|.||.||.:.|||:.:|.|.:|:|||.||:||.|||||||||.|:|||
  Rat  1008 --KPDACEGNLEFREVSFFYPCRPEVPVLQDMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDP 1070

  Fly  1131 DEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMAN 1195
            .:|::|:|...: .:::::.||.:..||||||.||..|||:||.|||.||.||:::|.|.|..||
  Rat  1071 MKGQVLLDGVDV-KELNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAAN 1134

  Fly  1196 AHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQAL 1260
            .|.||..||.:|.|.:|.:|..||||||||:|||||::|.||||||||||||||.:||::|||||
  Rat  1135 IHSFIEGLPGKYSTQVGLRGMHLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKMVQQAL 1199

  Fly  1261 DSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKL 1312
            |.|..||||:|:||||||||||::|.|:|.|:|.|||:|.:||.....|.||
  Rat  1200 DKARRGRTCLVVAHRLSTIQNADMIVVLQNGRIKEQGTHQELLRNGETYFKL 1251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	220/509 (43%)
		MdlB	723..1320	CDD:440747	232/591 (39%)
Abcb5	XP_006240775.1	PTZ00265	48..1252	CDD:240339	480/1275 (38%)