DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10226 and Abcb11

DIOPT Version :9

Sequence 1:NP_648040.1 Gene:CG10226 / 38725 FlyBaseID:FBgn0035695 Length:1320 Species:Drosophila melanogaster
Sequence 2:NP_001350421.1 Gene:Abcb11 / 27413 MGIID:1351619 Length:1321 Species:Mus musculus


Alignment Length:1330 Identity:494/1330 - (37%)
Similarity:775/1330 - (58%) Gaps:87/1330 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 KKKKTKEKAQ---PMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERT 85
            ||.:.::|.:   ..|.:.||||:.:..|..::..|.|.|.|..:..|..|:|:..|..:|:|..
Mouse    30 KKSRLQDKKKGEGARVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGILTDIFVEYD 94

  Fly    86 LGQGTSSV--------TIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVY 142
            :.:...|:        ||         :..|:|:.:||    .:..|.| |:.:|:.::.|||:|
Mouse    95 IERQELSIPEKVCMNNTI---------VWINSSFNQNM----TNGTSCG-LVDINSEVIKFSGIY 145

  Fly   143 -----YVDAFNRLALKLTV--------RMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIR 194
                 .|.......::|.|        :||:.:|:..:|.||||.|.........|.:|::.||.
Mouse   146 AGVGVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRFSDDINKID 210

  Fly   195 SGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYV 259
            ..||:.:..:::.:...:..::|.|..||||.|.|:...||..:..:.:.....|.|..|..:|.
Mouse   211 EAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTELELKAYA 275

  Fly   260 RASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGS 324
            :|.|:.:||:.:||||.|||||..|..||:..|..|.:.|.|||...|.....|..::|...|.:
Mouse   276 KAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIFFCYALA 340

  Fly   325 FWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDV 389
            ||||:.|:|         ||.||||..::.:...:|::|..|...|..||.|:....:||:|...
Mouse   341 FWYGSRLVL---------DEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQT 396

  Fly   390 IDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCG 454
            |||..::|.:|..|..|: .:||.:||.:|.|.||:|.:|.:|..|::|::.|:|.|.||.||.|
Mouse   397 IDRQPVMDCMSGDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAG 460

  Fly   455 KSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQ 519
            |||.:||:||||||..|.|.|||.|:|..||:|||..|.:|.||||||..:|.||||.|:.|||.
Mouse   461 KSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEATM 525

  Fly   520 KEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALD 584
            :::..|||.|||::||:||.:.:||.:.|.|.|:||||:||:|||||||::|||||||.||||||
Mouse   526 EDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSALD 590

  Fly   585 YHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVT 649
            ..||..||.||:|...|.|.:.|:||||.:|.|..|:..|:|.|||:||||||::.:|.|..:||
Mouse   591 NESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFMLVT 655

  Fly   650 VHSYDDSA-EELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLA----- 708
            :.|.:|:. :|...:.::..|....:.::....||...|.||....|:....:.:...||     
Mouse   656 LQSQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLSHLSHEPPLAIGDHK 720

  Fly   709 --------NITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVL 765
                    |..:.:|::...|.         |||.:...||.::::||:||.:.|...|::|::.
Mouse   721 SSYEDRKDNDVLVEEVEPAPVR---------RILKYNISEWPYILVGALCAAINGAVTPIYSLLF 776

  Fly   766 AELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMN 830
            :::..:.:....|:...:..||.:..:::|..:....::|.:.|..:|..||.|:|...|:.::.
Mouse   777 SQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLR 841

  Fly   831 QEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLS 895
            |::||||..:|:.|.|:.||:.||:.||||.|..:..::.:|||...::.|||.::|:|:|:...
Mouse   842 QDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVISV 906

  Fly   896 TSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYR 960
            ..||:..|...:.:.....|.::||:||:..:|..|.::.||||||:..|...||.::.|:|:..
Mouse   907 FFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFIKAFEVELEKSY 971

  Fly   961 HQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLA 1025
            ...:.:....||..:..:.:.|...:....|||::.....:.|..:.::.:::......:.::.:
Mouse   972 KTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIAMSATAVGRTFS 1036

  Fly  1026 FTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPH 1090
            :||::..|.:||.|.::::||||.|..         .:|...|.:..|..:.:....|:|||||.
Mouse  1037 YTPSYAKAKISAARFFQLLDRKPPIDV---------YSGAGEKWDNFQGKIDFIDCKFTYPSRPD 1092

  Fly  1091 IKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHD---MDLKTLR 1152
            |:||...::.::.|||:|.||:||.||||.:|||.|:||||:|.::||    .||   ::::.||
Mouse  1093 IQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMID----GHDSKKVNVQFLR 1153

  Fly  1153 RRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQ 1217
            ..:|||||||.||:.||.|||.|||.::::.:::.|.|||.|..|:|:||||.:|:|.:|.:|:|
Mouse  1154 SNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQ 1218

  Fly  1218 LSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNA 1282
            ||.|:|||||||||:||:||||||||||||||.:||:.||.|||.|..||||||||||||||||:
Mouse  1219 LSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNS 1283

  Fly  1283 NVICVIQAGKIVEQGSHSQLLAKNGIYSKL 1312
            ::|.|:..|.::|:|:|.:|:.:.|.|.||
Mouse  1284 DIIAVMSQGVVIEKGTHKKLMDQKGAYYKL 1313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10226NP_648040.1 PTZ00265 81..1311 CDD:240339 475/1267 (37%)
ABC_membrane <147..333 CDD:279056 62/193 (32%)
ABC_MTABC3_MDL1_MDL2 414..649 CDD:213216 130/234 (56%)
ABC_membrane 749..1019 CDD:279056 71/269 (26%)
ABC_MTABC3_MDL1_MDL2 1076..1316 CDD:213216 132/240 (55%)
Abcb11NP_001350421.1 AAA 29..1314 CDD:333001 494/1330 (37%)
Interaction with HAX1. /evidence=ECO:0000250 651..674 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..722 10/59 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 198 1.000 Domainoid score I3072
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2081
OMA 1 1.010 - - QHG63700
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.670

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