Protein Alignment CG10226 and Abcb4

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_036822.1
• Gene: Abcb4 / 24891
• RGDID: 620248
• Length: 1278
• Species: Rattus norvegicus
• Alignment Length: 1333
• Identity: 535/1333 - (40%)
• Similarity: 792/1333 - (59%)
• Gaps: 87/1333 - (6%)

  Fly     9 DVPAA--------DADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSL 65
            |:.||        |.|....:...:.:.|:|...::....||||....|.|.:|.|...|.....
  Rat     2 DLEAARNGTARRLDGDFELGSISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGS 66

  Fly    66 VFPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELR--KDSVSFGIL 128
            ..|:.::|:.|:...|::.. |..:..|...||:...|:||     ||.|....  ...:..|:|
  Rat    67 GLPLMMIVFGEMTDKFVDNA-GNFSLPVNFSLSMLNPGRIL-----EEEMTRYAYYYSGLGGGVL 125

  Fly   129 MTLNTLLMLFSGVYYVDAFNRLALKLTVR-MRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEK 192
            :          ..|...:|..||....:| :|::||.|.||||:||.|:........|:||::.|
  Rat   126 L----------AAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEMGWFDIKGTTELNTRLTDDISK 180

  Fly   193 IRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAV-AHYQGKLTGQEQS 256
            |..||.:.:|.:.:.:.......::.||.||||.| ::..|...|.:::|| |......:.:|.:
  Rat   181 ISEGIGDKVGMFFQAIATFFAGFIVGFIRGWKLTL-VIMAITAILGLSTAVWAKILSTFSDKELA 244

  Fly   257 SYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITG 321
            :|.:|.:|.||.:||||||:||||:..|..||...|:.|.|.|..|...:.:|..:...:::.:.
  Rat   245 AYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASY 309

  Fly   322 AGSFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAI 386
            |.:||||:.|::          .:|||....|.|...|::.|..:.:.:|.::.|..|||:|..|
  Rat   310 ALAFWYGSTLVI----------SKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVI 364

  Fly   387 LDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPS 451
            .|:||....||..|:.|...: .:||.:||.||.|.||:|.::.:|:|||:.|:.||||||||.|
  Rat   365 FDIIDNNPKIDSFSERGHKPD-SIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNS 428

  Fly   452 GCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPE 516
            ||||||.:|||||.|||..|.:.:||:|:|.:|::.||..|.||.||||||..:|.||||:|:..
  Rat   429 GCGKSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGN 493

  Fly   517 ATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATS 581
            .|..|::.|.|.|||:|||:.|.:.:||.:.::|.||||||:|||||||||::.|||||||||||
  Rat   494 VTMDEIKKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATS 558

  Fly   582 ALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHK 646
            |||..||..||||||||.:||||:|::||||.:|:|..|...|:|..||||:|.||:|.||.|.:
  Rat   559 ALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFR 623

  Fly   647 MVTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANIT 711
            :|.:.:   |..::|:|..|| |:.:.|.:..|.|.....|....|.:|:.:....:.|.| ::.
  Rat   624 LVNMQT---SGSQILSEEFEV-ELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRL-DVE 683

  Fly   712 MNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPT 776
            .|:.  |..||..:|:    ::|...:.||.:.::|.:||...|...|.||::|:|:. ::..|.
  Rat   684 TNEL--DANVPPVSFL----KVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMI-AIFGPG 741

  Fly   777 DEEVLEQSASM-AIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKE 840
            |:.|.:|..:| :::.|.:|:.:....::|.|.|..||..||||:||..|:.::.|:|.|||..:
  Rat   742 DDTVKQQKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHK 806

  Fly   841 NSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIV 905
            ||.||||.||:.|||.||||.|..|:.|.|...|....|.|:|.|.|:|.|:.||..||:..:.:
  Rat   807 NSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGI 871

  Fly   906 FEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVER----YRHQILSR 966
            .|.:....:|.::|:.:|...:||||.|..||||..|.:|.:...:|   ||:    ||:.: .:
  Rat   872 VEMKMLAGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMY---VEKLHGPYRNSV-RK 932

  Fly   967 LKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFN 1031
            ....|:..|:.::.|:|.||....:|.::..:|.::|:.::.:.:.::.|...|..:.:|.|.:.
  Rat   933 AHIYGITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYA 997

  Fly  1032 AALLSANRMYEIIDRKPQIQS-------PESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRP 1089
            .|.|||..::.:.:|:|.|.|       |:.||                ..|::..:.|:||:|.
  Rat   998 KAKLSAAYLFSLFERQPLIDSYSREGMWPDKFE----------------GSVTFNEVVFNYPTRA 1046

  Fly  1090 HIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILID-QESIHHDMDLKTLRR 1153
            ::.|||..:|::.:|||:||||:||.||||.||||.|:|||..|.:|:| ||:  ..::::.||.
  Rat  1047 NVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVLLDGQEA--KKLNVQWLRA 1109

  Fly  1154 RLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQL 1218
            :||||||||.||:.|||.||.|||.||.|...:|:.|||.||.|.||.:||.:|:|.:|.|||||
  Rat  1110 QLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQL 1174

  Fly  1219 SGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNAN 1283
            |||||||||||||::|.|::|||||||||||.:||:|||:|||.|..|||||||||||||||||:
  Rat  1175 SGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNAD 1239

  Fly  1284 VICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQ 1316
            :|.||..||:.|.|:|.||||:.|||..:...|
  Rat  1240 LIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	227/506 (45%)
		MdlB	723..1320	CDD:440747	257/607 (42%)
Abcb4	NP_036822.1	PTZ00265	29..1271	CDD:240339	529/1303 (41%)
		MdlB	42..632	CDD:440747	254/620 (41%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385	622..646		7/27 (26%)