Protein Alignment CG10226 and Tap1

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_114444.2
• Gene: Tap1 / 24811
• RGDID: 3817
• Length: 725
• Species: Rattus norvegicus
• Alignment Length: 624
• Identity: 187/624 - (29%)
• Similarity: 307/624 - (49%)
• Gaps: 78/624 - (12%)

  Fly    49 DYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEE 113
            |.|..:.||:.:....|...:.:::.|.|..|.|....|:.|..:.         :..|..|:..
  Rat   148 DMLCRMLGFLDSKKGRLHLVLVLLILSCLGEMAIPFFTGRITDWIL---------QDKTAPSFAR 203

  Fly   114 NMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLAL-KLTVRMRREFFKATLRQEIGWHDMA 177
            ||..:        .::|:.:..:.|:|    |....:.: .:..|:..|.|:|.|.||.|:....
  Rat   204 NMWLM--------CILTVASTALEFAG----DGIYNITMGHMHSRVHGEVFRAVLHQETGFFLKN 256

  Fly   178 KDQNFAVRITDNMEKIRSGIAENLGHYV----EIMCDVIISVVLSF-IYG-WKLALAIVFYIPLT 236
            ...:...|:|::...:...|::.|..::    ..:|      :|:| |:| :.|.:..:..:||.
  Rat   257 PTGSITSRVTEDTSNVCESISDKLNLFLWYLGRGLC------LLAFMIWGSFYLTVVTLLSLPLL 315

  Fly   237 LVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGK- 300
            .::...:......|..:.|.|..:::.|..|.:.|:.||.:|..|..|:.::...|:......|
  Rat   316 FLLPRRLGKVYQSLAVKVQESLAKSTQVALEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKK 380

  Fly   301 ---------WKGAFSGLSDTV----MKAMLFITGAGSFWYGANLILYYRDPSIPIDEREYTPAVV 352
                     |..:.||:...|    :...|.:.||.|.....:.:||         :.::|.||.
  Rat   381 EALAYVTEVWTMSVSGMLLKVGILYLGGQLVVRGAVSSGNLVSFVLY---------QLQFTRAVE 436

  Fly   353 MIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGAVEFR 417
            :::               ....:...:.|::..|.:.:|||. ..|||  |.:....:||.|:|:
  Rat   437 VLL---------------SIYPSMQKSVGASEKIFEYLDRTP-CSPLS--GSLAPLNMKGLVKFQ 483

  Fly   418 DVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRK 482
            ||.|.||...:|.||:||...:..|:..|||||:|.||||...|||..|.|..|:||||||.:.:
  Rat   484 DVSFAYPNHPNVQVLQGLTFTLYPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGELLVQ 548

  Fly   483 YNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEA-TQKEVEDAAKAANAHDFIIALHKGYDTDI 546
            |:..:|.:.:|.|||||:||..|..|||.:|.... |.:|:...|..:.|||||....:||||::
  Rat   549 YDHHYLHTQVAAVGQEPLLFGRSFRENIAYGLTRTPTMEEITAVAMESGAHDFISGFPQGYDTEV 613

  Fly   547 SEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACK--GRTTLVVSH 609
            .|.|.||||||||.:|:|||||::|::|:||:||||||..::..||..|.::.:  .||.|:::.
  Rat   614 GETGNQLSGGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWASRTVLLITQ 678

  Fly   610 RLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMV 648
            :||....||.|::::.|...|||||.:||:..|.|..||
  Rat   679 QLSLAERAHHILFLKEGSVCEQGTHLQLMERGGCYRSMV 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	168/526 (32%)
		MdlB	723..1320	CDD:440747
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	185/622 (30%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	352..397		9/44 (20%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03518	430..464		8/49 (16%)