DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and ABCB10

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_036221.2	Gene:	ABCB10 / 23456	HGNCID:	41	Length:	738	Species:	Homo sapiens

Alignment Length:	626	Identity:	213/626 - (34%)
Similarity:	335/626 - (53%)	Gaps:	70/626 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 PSANFISTFFRILGWARPE-------WSFLIIGAICAGLYGVTMPVF-SVVLAELYGSLAKPTDE 778
            |:|..:....::||.|.||       ..||.:.::.:    ::.|.| ..::..:|   ..||
Human   149 PAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVIS----MSAPFFLGKIIDVIY---TNPT-- 204

  Fly   779 EVLEQSASMAIISLVIGIAAGVVC-----YIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDR 838
              ::.|.::.  .|.:|::|..:|     .|:.:....:|..:..|:|:..|..|:.||:.:||:
Human   205 --VDYSDNLT--RLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDK 265

  Fly   839 KENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVAS 903
            ...  |.|..|||.|.|.:..::...||:.::|.......|::.|..|..||...||..|.:...
Human   266 TRT--GELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSII 328

  Fly   904 IVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERY----RHQIL 964
            .|...|:..|.....::.|.:.:::|.|.|..:|||....:|...|:.|..:|:..    |.:..
Human   329 AVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAF 393

  Fly   965 SRLKWRGLVNSLGKSLMFFGYAVTLTYGG-------HMCADGKIKFETIMKISNTMLYGLFILAQ 1022
            :|..:.|.....|..::     :::.|.|       ||         |:.::|:.::|. |.:..
Human   394 ARAGFFGATGLSGNLIV-----LSVLYKGGLLMGSAHM---------TVGELSSFLMYA-FWVGI 443

  Fly  1023 SLAFTPAFNAALL----SANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNF 1083
            |:....:|.:.|:    :..|::|:::|:|::...|         |........|..:.::.::|
Human   444 SIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNE---------GVILNEKSFQGALEFKNVHF 499

  Fly  1084 SYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDL 1148
            :||:||.:.:.|:|:|.|..|...||||.|||||||.:.||:|.|||..|.|.:|...| ..::.
Human   500 AYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDI-RQLNP 563

  Fly  1149 KTLRRRLGIVSQEPSLFEKSIADNIGYG-DTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLG 1212
            ..||.::|.|||||.||..|||:||.|| |....|..::|...|::|||..||.:.|..::||:|
Human   564 VWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVG 628

  Fly  1213 SKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLS 1277
            .||..||||||||||||||:::|||||||||||||||.::|.:||:|||....|||.:|||||||
Human   629 EKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLS 693

  Fly  1278 TIQNANVICVIQAGKIVEQGSHSQLLAK-NGIYSKLYRCQT 1317
            ||:|||::.|:..|||.|.|.|.:||:| ||||.||...|:
Human   694 TIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	210/618 (34%)
		ABC_membrane	<147..333	CDD:279056
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216
		ABC_membrane	749..1019	CDD:279056	63/286 (22%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	129/241 (54%)
ABCB10	NP_036221.2	mitochondrial targeting sequence	1..105
		PWWP	1..>26	CDD:295359
		MdlB	163..734	CDD:224055	208/610 (34%)
		ABC_membrane	177..438	CDD:279056	64/289 (22%)
		ABC_MTABC3_MDL1_MDL2	493..733	CDD:213216	129/240 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910