Protein Alignment CG10226 and Tap2

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_035660.3
• Gene: Tap2 / 21355
• MGIID: 98484
• Length: 702
• Species: Mus musculus
• Alignment Length: 616
• Identity: 182/616 - (29%)
• Similarity: 303/616 - (49%)
• Gaps: 80/616 - (12%)

  Fly   732 RILGWARPEWSFLIIG--AICAGLYGVTM-PVFSVVLAELYGSLAKPTDEEVLEQSAS----MAI 789
            |:|..:||:..|||..  .:...::|.|: |.:|..:.::.|....|      :..||    |.:
Mouse   139 RLLKLSRPDLPFLIAAFFFLVVAVWGETLIPRYSGRVIDILGGDFDP------DAFASAIFFMCL 197

  Fly   790 ISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDA 854
            .|:....:||  |...:|.|.::.:.|  |:|.:.|..::.|::|:|  :|...|.|::|||.|.
Mouse   198 FSVGSSFSAG--CRGGSFLFTMSRINL--RIREQLFSSLLRQDLGFF--QETKTGELNSRLSSDT 256

  Fly   855 ASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVAS-IVFEARFGEKSALKE 918
            :.:...:.|..:.::::....:.........|..|..:.|...|..:|: .|:..|  .::.|||
Mouse   257 SLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPR--HQAVLKE 319

  Fly   919 -KEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWR-----------G 971
             ::.:.:..::..|.:..::||.....||:.:..|.:.:||.|     :|.||           .
Mouse   320 IQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCR-----QLWWRRDLEKDVYLVIR 379

  Fly   972 LVNSLGKSLMFFGYAVTLTYGGHMCADGKIKF----ETIMKISNTMLYGLFILAQSLAFTPAFNA 1032
            .|.:||..::.....|.....|.:...|.:.|    |.:.:....::|....:..::.
Mouse   380 RVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNVG------- 437

  Fly  1033 ALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNF 1097
               :|.:::..:||||.:..|           .......::..|.::.::||||.||...|||..
Mouse   438 ---AAEKVFSYLDRKPNLPQP-----------GILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGL 488

  Fly  1098 NLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESI----HHDMDLKTLRRRLGIV 1158
            ...::.|...||||.:||||||...||...|.|..|::|:|.|.:    ||     .|.|::.:|
Mouse   489 TFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHH-----YLHRQVVLV 548

  Fly  1159 SQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQK 1223
            .|||.||..|:.|||.||  .|.....|::.||:.|.|.:||..:....:|.:|.||.||:.|||
Mouse   549 GQEPVLFSGSVKDNIAYG--LRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQK 611

  Fly  1224 QRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVI 1288
            ||:|||||:||||::|:|||||||||.|.|:.:|.....  ..||.:||||||.|:|||:.:.|:
Mouse   612 QRLAIARALVRNPRVLILDEATSALDAQCEQALQNWRSQ--GDRTMLVIAHRLHTVQNADQVLVL 674

  Fly  1289 QAGKIVEQGSHSQLLAKNGIYSKLYRCQTKA 1319
            :.|::||   |.||.....:|:.|.:.:.:|
Mouse   675 KQGRLVE---HDQLRDGQDVYAHLVQQRLEA 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747
		MdlB	723..1320	CDD:440747	182/616 (30%)
Tap2	NP_035660.3	3a01208	1..696	CDD:273363	180/608 (30%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	300..388		22/94 (23%)
		Part of the peptide-binding site. /evidence=ECO:0000250|UniProtKB:Q03519	413..432		2/18 (11%)