DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and pgp-7

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001361833.1	Gene:	pgp-7 / 188697	WormBaseID:	WBGene00004001	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1223	Identity:	358/1223 - (29%)
Similarity:	597/1223 - (48%)	Gaps:	121/1223 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DEATP-AAQKKKKTKEKAQPMVSYTE-LFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELV 78
            |..|| .||..:|   |...:.|:.. :|:..:.::..:.|.|...:.:..|..|
Worm     7 DYTTPLIAQSNEK---KPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQP---------- 58

  Fly    79 AMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQ--ELRKDSVSFGILMTLNTLLMLFSG- 140
              |:..|||: |:.|.:         .:|||...:.:.  :|:|....:...|....|.....|
Worm    59 --FVSYTLGE-TAQVLV---------TITNAINNKTIDPADLKKAYEQYERGMYQVVLYFFLCGC 111

  Fly   141 VYYVDAFNRLAL------KLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAE 199
            .|:..|..:.|:      ..|.|:|:::....||::..:.|.....:.:..:.||:|:.|....|
Worm   112 AYFTFASIQHAIMKYVGDNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNE 176

  Fly   200 NLGHYVEIMCDVIISVVLSFIYGWKLALAIVFY---IPLTLVVNSAVAHYQGKLTGQEQSSYVRA 261
            .:.....::.|.::...|:|...|:||...:|:   |..:..:|||...   |.||::.:.|..|
Worm   177 KIALIFALLTDFVVGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVM---KTTGKQNTHYANA 238

  Fly   262 SSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFW 326
            .|:..:.:||.:||.:..|:.:|..||...||...|.|            :.:|:::....|..:
Worm   239 GSIAFQTLGAYKTVCSLNGQNTEIERYTEELKAGEKYG------------IHRALMYSISRGFTY 291

  Fly   327 YGAN----LILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAIL 387
            :..|    :|||.....|.....|  ||||:.:...::..|..:|...|.:...|.|..|.:.|.
Worm   292 FFCNSLNTVILYVGANMIYSGSLE--PAVVVRIFHYMMFGAFCLSEALPHISRLAGAISSTAPIA 354

  Fly   388 DVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSG 452
            :::.:...:....:....:...:.|.:.|::|.|.||.|.|..||:|::..|:.|:.:||||.||
Worm   355 EMLIKEDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASG 419

  Fly   453 CGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEA 517
            .||||.:|||..:|:...|.:.:||.|:...|||.||..|.||.||||||..:|.||||.|.|..
Worm   420 SGKSTVVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNV 484

  Fly   518 TQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSA 582
            :..|:..|.:.|||:||:.:..||..|.:.|:|.||||||:|||||||.|::.||||||||||||
Worm   485 SLPEIYGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSA 549

  Fly   583 LDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKM 647
            ||..||::||.||:.|.:||||:||:||||.||:|.:|:.::.|:.||.|.|:||:...|.|:.:
Worm   550 LDNESEQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDL 614

  Fly   648 V---TVHSYDDSAEELLNELEEVAEIKERKMSYEVEP-----YQLGTRNSIVSLEKNAEFQMKNL 704
            |   .:.|:||.        ||:..:..|::|.|:.|     .|..|.|..
Worm   615 VQAQLLESHDDH--------EELPPLAARQLSQELSPLHSYAIQRSTSNDA-------------- 657

  Fly   705 NGLANITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELY 769
             |:.:..|.:.:|:.....|. .|....|:...||::.||.|....:.:.||:.|:.:.::...|
Worm   658 -GVHDDDMERILDELSKEGAK-KSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTY 720

  Fly   770 GSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMG 834
            ...|. ..|::|..|...|:..:.:.:...:..|.|.::|......|:||:|.|:|..:::....
Worm   721 EGFAM-IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCA 784

  Fly   835 WFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPF 899
            ::|...:|...||.||:.|:::|:.|:...|..:|........:|..|..|.|::.|..|...|.
Worm   785 FYDDPNHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPL 849

  Fly   900 M-VASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQI 963
            : :|...::|. .|.|..::....|.::|.|.|.:..:|||..|..|::::.:..:.:::.....
Worm   850 LYLAEYCYDAA-TETSIQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSY 913

  Fly   964 LSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMC-------ADGKIKFETIMKISNTMLYGLFILA 1021
            ..|...:|..|.|..|...|.|:|:..:|.::.       .|..:..||:...:|       :..
Worm   914 FKRAIIQGAANGLSLSCYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTAN-------MAG 971

  Fly  1022 QSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYP 1086
            .:.|:.|.:..|:.:|..::.:      ...|.:.....:..    |.|:.:..:....:.|.|.
Worm   972 SAAAYLPDYKKAVHAAGLIFHL------FTYPATMPFSSSDG----KKNIEKGEIIGENVQFHYD 1026

  Fly  1087 SRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTL 1151
            .||...:|...||.::.|:|:||||.||.||||.:.||.|:|...:|::.||.|:: .|::|..|
Worm  1027 QRPDRMILNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV-EDINLNHL 1090

  Fly  1152 RRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLP 1204
            |..|.:|||||:||..||.:|:.||.| |.||..::.:|.:.|||..|:...|
Worm  1091 RSNLALVSQEPTLFNCSIRENLLYGLT-RSVPQLELEKALQTANAFNFVFQFP 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	345/1156 (30%)
		ABC_membrane	<147..333	CDD:279056	44/198 (22%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	122/237 (51%)
		ABC_membrane	749..1019	CDD:279056	62/277 (22%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	54/129 (42%)
pgp-7	NP_001361833.1	MdlB	42..621	CDD:224055	203/617 (33%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	122/236 (52%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	71/322 (22%)
		TM helix 1	695..718	CDD:350022	5/22 (23%)
		TM helix 2	733..781	CDD:350022	11/47 (23%)
		TM helix 3	790..835	CDD:350022	12/44 (27%)
		TM helix 4	836..885	CDD:350022	12/49 (24%)
		TM helix 5	897..947	CDD:350022	9/49 (18%)
		TM helix 6	956..989	CDD:350022	7/39 (18%)
		P-loop_NTPase	1019..>1143	CDD:393306	54/126 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.880