Protein Alignment CG10226 and Abcb1a

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_035206.2
• Gene: Abcb1a / 18671
• MGIID: 97570
• Length: 1276
• Species: Mus musculus
• Alignment Length: 1333
• Identity: 526/1333 - (39%)
• Similarity: 799/1333 - (59%)
• Gaps: 79/1333 - (5%)

  Fly     5 ETREDVPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGW-DYLVLLSGFVAAFLQSLVFP 68
            |..||:........:...:|.||.|::.:|.||...:||| ||| |.|.:|.|.:||.:..:..|
Mouse     2 ELEEDLKGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRY-AGWLDRLYMLVGTLAAIIHGVALP 65

  Fly    69 IAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNT 133
            :.::::.::...|         :||         |.:..|::   ||.|..|.::...:...:.|
Mouse    66 LMMLIFGDMTDSF---------ASV---------GNVSKNST---NMSEADKRAMFAKLEEEMTT 109

  Fly   134 LLMLFSGV--------YYVDAFNRLALKLTV-RMRREFFKATLRQEIGWHDMAKDQNFAVRITDN 189
            ....::|:        |...:|..||....: ::|::||.|.:.|||||.|:........|:||:
Mouse   110 YAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDD 174

  Fly   190 MEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQE 254
            :.||..||.:.:|.:.:.|.......::.|..||||.|.|:...|:..:.....|......|.:|
Mouse   175 VSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKE 239

  Fly   255 QSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFI 319
            ..:|.:|.:|.|||:.|||||:||||::.|..||::.|:.|.:.|..|...:.:|......:::.
Mouse   240 LHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYA 304

  Fly   320 TGAGSFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSAS 384
            :.|.:||||.:|::          .:||:...|:.|...:::.|..:.:.||.:|.||.|||:|.
Mouse   305 SYALAFWYGTSLVI----------SKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAY 359

  Fly   385 AILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVG 449
            .:..:||....||..||:|...: .::|.:||:::.|.||:|::|.:|:|||:.|:.||||||||
Mouse   360 EVFKIIDNKPSIDSFSKSGHKPD-NIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVG 423

  Fly   450 PSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGK 514
            .|||||||.:||:||.|||:.|.|.:||:|:|..|:::||..|.||.||||||..:|.||||:|:
Mouse   424 NSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGR 488

  Fly   515 PEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEA 579
            .:.|..|:|.|.|.|||:|||:.|...:||.:.|:|.||||||:|||||||||::.|||||||||
Mouse   489 EDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEA 553

  Fly   580 TSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFY 644
            |||||..||.:||||||||.:||||:|::||||.:|:|..|...:.|..||||.|:|||:.:|.|
Mouse   554 TSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIY 618

  Fly   645 HKMVTVHSYDDSAEELLNELE---EVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNG 706
            .|:|...:..       ||:|   |..:.|:     |::...:.:::|..||.:....: |::.|
Mouse   619 FKLVMTQTAG-------NEIELGNEACKSKD-----EIDNLDMSSKDSGSSLIRRRSTR-KSICG 670

  Fly   707 L----ANITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAE 767
            .    ..::..:.:|:. ||.|    :|:|||.....||.:.::|..||.:.|...|.|||:.::
Mouse   671 PHDQDRKLSTKEALDED-VPPA----SFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSK 730

  Fly   768 LYGSLAKPTDEEVLEQSASM-AIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQ 831
            :.|........|...|:::: :::.|::||.:.:..::|.|.|..||..||.|:|...|:.::.|
Mouse   731 VVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQ 795

  Fly   832 EMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLST 896
            ::.|||..:|:.|||:.||:.|||.|:||.|..|:.|.|...|....|.|:..|.|:|.|:.|:.
Mouse   796 DVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAI 860

  Fly   897 SPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRH 961
            .|.:..:.|.|.:.....|||:|:.||.:.:||||.|...|||..|.||::...:|.:.::....
Mouse   861 VPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYR 925

  Fly   962 QILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAF 1026
            ..:.:....|:..|..:::|:|.||....:|.::.....:.||.::.:.:.:::|...:.|..:|
Mouse   926 NAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSF 990

  Fly  1027 TPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHI 1091
            .|.:..|.:||:.:..||::.|:|   :|:..|      ..|.|:::..|.:.|:.|:||:||.|
Mouse   991 APDYAKATVSASHIIRIIEKTPEI---DSYSTQ------GLKPNMLEGNVQFSGVVFNYPTRPSI 1046

  Fly  1092 KVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLG 1156
            .|||..:|::.:|||:||||:||.||||.||||.|:|||..|.:.:|.:.| ..::::.||.:||
Mouse  1047 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEI-KQLNVQWLRAQLG 1110

  Fly  1157 IVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGG 1221
            ||||||.||:.|||:||.|||.||.|..::|:.|||.||.|:||.|||.:|:|.:|.||||||||
Mouse  1111 IVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGG 1175

  Fly  1222 QKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVIC 1286
            ||||||||||:||.|.||||||||||||.:||:|||:|||.|..|||||||||||||||||::|.
Mouse  1176 QKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIV 1240

  Fly  1287 VIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTKA 1319
            |||.||:.|.|:|.||||:.|||..:...|..|
Mouse  1241 VIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGA 1273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	222/505 (44%)
		MdlB	723..1320	CDD:440747	255/598 (43%)
Abcb1a	NP_035206.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		6/23 (26%)
		PTZ00265	47..1263	CDD:240339	505/1275 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..681		5/35 (14%)