Protein Alignment CG10226 and pgp-13

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_001359545.1
• Gene: pgp-13 / 184845
• WormBaseID: WBGene00004007
• Length: 1323
• Species: Caenorhabditis elegans
• Alignment Length: 1344
• Identity: 457/1344 - (34%)
• Similarity: 702/1344 - (52%)
• Gaps: 152/1344 - (11%)

  Fly    33 QPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSEL--VAMFIERTLGQGTSSVTI 95
            || ||..:|||:...:||::||.|.:.:.:..:..|:..::...:  |.:.|:....:..:....
 Worm    74 QP-VSLLQLFRFATTFDYILLLIGLITSVISGVSQPVLAIISGRMTNVLLVIDPLSKEFKTKTME 137

  Fly    96 GLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLALKLTVRMRR 160
            .:.:|.|                      .||.:::|......       .|.|:..::...||.
 Worm   138 NVYIFLG----------------------LGIFVSINDFCQYM-------CFQRVCSRMMTVMRN 173

  Fly   161 EFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKL 225
            .:..:.|||..||.|.........|:.||||:|:.|:.:.||..:..:..||.|||:|.||.|:|
 Worm   174 RYISSILRQNAGWFDKNLSGTITTRLNDNMERIQDGVGDKLGVLIRGISMVIASVVISLIYEWRL 238

  Fly   226 ALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDS 290
            ||.::..||::.:..:.::.:..|.||:|......|.::.||.:..:||:.||.|:.....:|:.
 Worm   239 ALMMLGLIPVSTICMTLLSRFLEKSTGEELEKVGEAGAIAEECLMGVRTIQAFNGQEEMVAKYEK 303

  Fly   291 LLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFW----------YGANLILYYRDPSIPIDER 345
            .|....|...|.|.:||          |..|...||          ||..|:      .:.|.:
 Worm   304 QLNSGKKHAIWGGFWSG----------FFGGIFFFWLMAFMGCGILYGGYLL------KVGIIK- 351

  Fly   346 EYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGL 410
              :|..|.|::..:::.|..:...||.|.....||.:|::|...|||...|||.|:.||.:. .:
 Worm   352 --SPGDVFIIVVAMLLGAYFLGLISPHLMVLLNARVAAASIYKTIDRVPKIDPYSRHGKKIE-KV 413

  Fly   411 KGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLL 475
            .|.|.|.:|.||||.|::..||.|||:.||.|.:|||||.|||||||.:.||.|.|:|..|.|.:
 Worm   414 VGKVTFENVHFRYPTRKEAKVLNGLNLTVEPGTSVALVGHSGCGKSTSVGLLTRLYEPEQGSVQI 478

  Fly   476 DGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHK 540
            ||.|||..|::|||:.:.:|.|||:||..:|..|:..|.|:||::.:....|.|||||||..:.|
 Worm   479 DGVDVRDLNLEWLRNVVGIVQQEPILFNDTIHNNLLFGNPDATRETMIRVCKMANAHDFIKKMPK 543

  Fly   541 GYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTL 605
            ||||.|.:.||||||||:||:||||.||:.||:|||||||||||..||.:||:||:.|.|||||:
 Worm   544 GYDTQIGDGGVQLSGGQKQRVAIARTLIRDPKVLLLDEATSALDAQSESVVQSALNNASKGRTTI 608

  Fly   606 VVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEI 670
            :::||||.||.|.:||:.|.|..||.|.||||:.|.|.|..:|...::....:|:..|.||..:.
 Worm   609 MIAHRLSTIREADKIVFFEKGVIVEAGNHEELVNLGGRYFDLVKAQAFKQDPDEIALEKEEEDQF 673

  Fly   671 KE--------RKMSYEVEPYQLGTRNSIVSLEKNA-EFQMKNLNGLANITMNQEIDDPRVPSA-- 724
            .|        ||:|         .|||..|....: ||:.   ..|||.:.::......:|||
 Worm   674 DEFDKPTVFNRKVS---------VRNSRSSGRSGSEEFRR---GSLANHSFDRFRKASHIPSAED 726

  Fly   725 ---------------NFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELY-GSLA 773
                           ...:.|..|...|:..:::::||...|.:.|:.:|.|:::.|.:: |...
 Worm   727 EAFALRVKETMEKDGEITAGFLDIFKNAQGNYTYMLIGLSAALIRGLDLPTFALLFAWVFEGFEF 791

  Fly   774 KPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDR 838
            .|...:::.:.|...|.....|:.......:.|..|.:....|..|.|...||.::.|:..:||.
 Worm   792 VPYGGKMMHRLAMSVIAHCAAGLGIWFFQTLSTVMFAIVSENLGVRFRVAAFRNLLYQDAAYFDN 856

  Fly   839 KENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTS-----P 898
            ..::.|:|..||:.|...|:..:...:..::.|....|..:.|.|...|::|:  |.|:     .
 Worm   857 PAHAPGSLITRLAADPPCVKAVVDGRMMQVVYATAAVIACVTIGFINCWQVAI--LGTALIFLLG 919

  Fly   899 FMVASIVFEARFGEKSALKEKEVLE--ETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRH 961
            |::|.:.|      |.::...|.:|  :..:||.|.|..::|:..|.|....:..|:.|.::.:.
 Worm   920 FIMAGLAF------KISIVAAEHMENDDAGKIAIEIIENVKTIQLLTRTRRFLNSYENESKKRKR 978

  Fly   962 QILSRLKWRGLVNSLGKSLMF------FGYAVTLTYGGHMCADGKIKFETIMKISNTML--YGLF 1018
            ..|.:..:..:...:.::.|:      |..|:.:...|....|     :|...:...||  .|:.
 Worm   979 TELRKSVYEAVNYCISQNFMYYMSCFCFALAIRIINQGDQTVD-----KTFRCLMAMMLCCEGII 1038

  Fly  1019 ILAQSLAFTPAFNAALLSANRMYEIIDRKPQ---IQSPESFEIQQNGNGTAYKTNVVQQGVSYRG 1080
            :.||   |.|.|..|..:|.:|:.:|:|:||   ::|....||:.|              :.:..
 Worm  1039 MSAQ---FFPQFVGAKSAAGQMFNLINRQPQTGDLKSGTKPEIRGN--------------ILFEN 1086

  Fly  1081 LNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHD 1145
            :.||||.|||..|::.......:||||||||.||||||||:.:|.|:||...|.:.:|.:.| .:
 Worm  1087 VKFSYPQRPHQPVMKQLQWTALRGQTVALVGPSGSGKSTCIGMLERFYDVTGGALRMDGQDI-KN 1150

  Fly  1146 MDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTV 1210
            :.|..||.::.:|.|||.||..:|.:|:..|  .:.||:::|.:|.::|||:.|:.:||...||.
 Worm  1151 ISLYHLRTQMALVGQEPRLFVGTIRENVCLG--LKDVPLEKINQALELANANRFLGNLPDGIDTE 1213

  Fly  1211 LGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHR 1275
            :|.:|.|||||||||||||||:||:||||||||||||||.:|||.||:|||.|..|||||.||||
 Worm  1214 VGERGGQLSGGQKQRIAIARALVRDPKILLLDEATSALDSESERAVQEALDRAREGRTCITIAHR 1278

  Fly  1276 LSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQTKA 1319
            ||:|||:::|..|..|::.|.|:|.:|:...|.|.:|.:.|..|
 Worm  1279 LSSIQNSDLIVYIDDGRVQESGTHKELMQLKGKYFELIKKQDLA 1322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	214/514 (42%)
		MdlB	723..1320	CDD:440747	205/633 (32%)
pgp-13	NP_001359545.1	MdlB	77..655	CDD:440747	231/626 (37%)
		PTZ00265	92..1317	CDD:240339	446/1318 (34%)