DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and pgp-6

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001041287.2	Gene:	pgp-6 / 181278	WormBaseID:	WBGene00004000	Length:	1263	Species:	Caenorhabditis elegans

Alignment Length:	1328	Identity:	414/1328 - (31%)
Similarity:	686/1328 - (51%)	Gaps:	118/1328 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PAAQKKKKTKEKAQPMVSYTE-LFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIE 83
            |.:.:||.::     :.|:.. :|:..:.::..:.|.|.:.:.:.....|            |:.
Worm    14 PQSDEKKPSQ-----ICSFIRVVFKCSSCFEKFLFLLGVLFSLMTGFCQP------------FMS 61

  Fly    84 RTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLF---SGVYYVD 145
            .|.|: .|.|.:.::.....|.:..|..|:..:|..:.         :|.::..|   ...|::.
Worm    62 YTFGE-VSQVLVTITNAINNKTIDPADLEKAYEEYERG---------MNQVVFHFFLCGCAYFIF 116

  Fly   146 AFNRLAL------KLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHY 204
            |..:.|:      ..|.|:|:::....|:::..:.|.....:.:..:.||:|:.|....|.:...
Worm   117 ASLQHAIMKYVGDNTTYRVRKQYISRLLKKDAQYFDSVSTGHLSTVLNDNLERFREVFNEKIALI 181

  Fly   205 VEIMCDVIISVVLSFIYGWKLALAIVFY---IPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVE 266
            :..:.|..:...|:|...|:||...:|:   |..:..:|||...   |.||::.:.|..|.|:..
Worm   182 IAFVTDFTLGTALAFYTDWRLASYGIFFSLGIAFSGFINSAGVM---KTTGKQNTHYANAGSIAF 243

  Fly   267 EVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGAN- 330
            :.:||.:||.:..|:::|..||...||...|.|            :.:|:::....|..::..|
Worm   244 QTLGAYKTVCSLNGQKTEIERYTEELKAGEKYG------------IRRALMYSISRGVTYFFCNS 296

  Fly   331 ---LILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDR 392
               ::||.....|.....|  .|||:.:...::..|..:|...|.:...|.|..|.:.|.:::.:
Worm   297 LNTVVLYVGATMIYSGTLE--TAVVVRLFHYMLFGAFCLSEALPHISRLAGAISSTAPIAEMLIK 359

  Fly   393 TSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKST 457
            ...:....:....:...:.|.:.|::|.|.||.|.|..||:|::..|:.|:.:||||.||.||||
Worm   360 DDNVIEKDETDYDVEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKST 424

  Fly   458 CIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEV 522
            .:|||..:|:...|.:.:||.|:...|||.||..|.||.||||||..:|.||||.|.|..:..|:
Worm   425 VVQLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEI 489

  Fly   523 EDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHS 587
            ..|.:.|||:||:.:..||..|.:.|:|.||||||:|||||||.|::.||||||||||||||..|
Worm   490 YGALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNES 554

  Fly   588 EKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMV---T 649
            |::||.||:.|.:||||:||:||||.||:|.:|:.::.|:.||.|.|:||:...|.|:.:|   .
Worm   555 EQVVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQAQL 619

  Fly   650 VHSYDDSAEELLNELEEVAEIKERKMSYEVEP-----YQLGTRNSIVSLEKNAEFQMKNLNGLAN 709
            :.|:||.        ||:..:..|::|.|:.|     .|..|.|..               |:.:
Worm   620 LESHDDH--------EELPPLAARQLSQELSPLHSYAIQRSTSNDA---------------GVHD 661

  Fly   710 ITMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAK 774
            ..|.:.:|:.....|. .|....|:...||::.||.|....:.:.||:.|:.:.::...|...|.
Worm   662 DDMERILDELSKEGAK-KSNLREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFAM 725

  Fly   775 PTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRK 839
             ..|::|..|...|:..:.:.:...:..|.|.::|......|:||:|.|:|..:::....::|..
Worm   726 -IGEDMLYYSHLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDP 789

  Fly   840 ENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFM-VAS 903
            .:|...||.||:.|:::|:.|:...|..:|........:|..|..|.|::.|..|...|.: :|.
Worm   790 NHSATRLSNRLNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLMFFPLLYLAE 854

  Fly   904 IVFEARFGEKSALKEKEV-LEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRL 967
            ..:||  ..::|::|..: .|.::|.|.|.:..:|||..|..|::::.:..:.:::.......|.
Worm   855 YCYEA--ATETAIQEDTIAFENSNRTAIEALENVRTVRALNLEDKIMSLISEHLQKIHKSYFKRA 917

  Fly   968 KWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKI----KFETIMKISNTMLYGLFILAQSLAFTP 1028
            ..:|..|.|..|...|.|:|:..:|.::....::    .:..:|.:|.|    ..:...:.|:.|
Worm   918 IIQGAANGLSLSCFLFVYSVSFKFGTYLALRKEVAPMDTYLVLMTLSMT----ANMAGSAAAYLP 978

  Fly  1029 AFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKV 1093
            .:..|:.:|..::.:      ...|.:.....:..    |.|:.:..:....:.|.|..||...:
Worm   979 DYKKAVHAAGLIFHL------FTYPATMPFSSSDG----KKNIEKGEIIGENVQFHYDQRPDRMI 1033

  Fly  1094 LQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIV 1158
            |...||.::.|:|:||||.||.||||.:.||.|:|...:|::.||.|:: .|::|..||..|.:|
Worm  1034 LNGVNLKVDPGKTLALVGPSGCGKSTIISLLERFYHAVDGEVKIDSENV-EDINLNHLRSNLALV 1097

  Fly  1159 SQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQK 1223
            ||||:||..||.:|:.||.| |.||..::.:|.:.|||..|:...|...||::|.:|.|||||||
Worm  1098 SQEPTLFNCSIRENLLYGLT-RSVPQLELEKALQTANAFNFVFQFPQGLDTLVGERGAQLSGGQK 1161

  Fly  1224 QRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVI 1288
            ||||||||::||||:|||||||||||..||:|||.|||:|....:.:|:||||||:.||:.|.|:
Worm  1162 QRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASERLSTVVVAHRLSTVVNADSIAVL 1226

  Fly  1289 QAGKIVEQGSHSQLLAKNGIYSKLYRCQ 1316
            :.||:.|||:|.:||.|..||.:|.:.|
Worm  1227 KNGKVAEQGTHEELLRKRSIYWRLVQKQ 1254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	404/1259 (32%)
		ABC_membrane	<147..333	CDD:279056	43/198 (22%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	122/237 (51%)
		ABC_membrane	749..1019	CDD:279056	62/275 (23%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	120/239 (50%)
pgp-6	NP_001041287.2	PTZ00265	32..1252	CDD:240339	409/1301 (31%)
		ABC_membrane	47..331	CDD:294371	64/322 (20%)
		ABC_MTABC3_MDL1_MDL2	381..618	CDD:213216	122/236 (52%)
		ABC_membrane	699..970	CDD:279056	62/277 (22%)
		ABC_MTABC3_MDL1_MDL2	1019..1254	CDD:213216	120/236 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930