DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and pgp-5

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001257116.1	Gene:	pgp-5 / 181276	WormBaseID:	WBGene00003999	Length:	1252	Species:	Caenorhabditis elegans

Alignment Length:	1286	Identity:	423/1286 - (32%)
Similarity:	674/1286 - (52%)	Gaps:	107/1286 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QSLVFPIAIVVYSELVAM---FIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVS 124
            :.|:|.:. ||:|.|..|   |...|||: ||.|.:.::.....|.:.........:....|
Worm    33 EKLLFFLG-VVFSILTGMCQPFESYTLGE-TSQVLVKVTNAINNKTIDPVDLAHAYKLFESD--- 92

  Fly   125 FGILMTLNTLLMLFSGV---YYVDAFNRLALKLTV------RMRREFFKATLRQEIGWHDMAKDQ 180
                  :|.:::||..|   |:...|.:.::...|      .:||::....||::|.:.|.....
Worm    93 ------MNRVVLLFFLVGFAYFTFGFLQFSIMKFVGDNTAYNVRRQYISRLLRKDISYFDGMSTG 151

  Fly   181 NFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVLSFIYGWKLA-LAIVFYIPLTLVVNSAVA 244
            :.::.:.||||:.|....|.:...:.::.|.:|..:|:|...|:|| ...||...:.|   |.:.
Worm   152 HLSIVLNDNMERFREVFNEKIALIIALLTDFVIGTILAFYTDWRLACYGTVFSFGIVL---SGLL 213

  Fly   245 HYQGKLTGQE-QSSYV-RASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSG 307
            ...||:...| |:.:: .|.|:..:.:|..:||.:..|::.|..||...||...|....:.....
Worm   214 DSWGKMKNNEKQNEHISNAGSIAFQALGCYKTVSSLNGQQQEVERYTEELKNGEKYALNRAFVFS 278

  Fly   308 LSDTVMKAMLFITGAGSF---WYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRT 369
            ||   ..|..|.|.|.:|   ::|||:|.          |....|.||:.::..|:..:..:...
Worm   279 LS---RSADYFFTNALNFVILYFGANMIY----------EGTIEPGVVVRILYYILFGSYCLGEA 330

  Fly   370 SPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLK----GAVEFRDVFFRYPAREDVI 430
            ...:...|.|......|.|:     |:|..:.|.:..:..:|    |.:.|::|.|.||.|.||.
Worm   331 ILHISRLASAIPLTVPIADI-----LLDSDATADEFFSEEIKDTFQGIISFKNVLFSYPTRPDVP 390

  Fly   431 VLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVV 495
            ||:.::..|:.|:.:||||.||.||||.||||..:|:...|::.:||.|:...|||.||..:.||
Worm   391 VLKEISFNVQGGECIALVGASGSGKSTVIQLLLHYYNIDSGRISIDGNDIYNINIKQLRQAMGVV 455

  Fly   496 GQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQR 560
            .||||||..||.||||.|||:||::|:.||.|.|||.||:.....|..|.:.|:|.||||||:||
Worm   456 FQEPVLFNTSIEENIRFGKPDATEQEIIDALKNANAFDFVCNFPDGIKTIVGERGAQLSGGQKQR 520

  Fly   561 IAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIEN 625
            |||||.|::.|:||||||||||||..||.:||.||.||..||||:||:||||.||:|::|:.:|.
Worm   521 IAIARTLVRNPRILLLDEATSALDNESEFIVQEALQKASIGRTTIVVAHRLSTIRNANKIIVMEK 585

  Fly   626 GKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSI 690
            |:.||.|.|::|:.:.|.|:.:|.......:.|: :||.||..                 ||.|
Worm   586 GEIVEVGDHKQLIAMNGVYNNLVQTQLMSTNYEK-MNENEERV-----------------TRQS- 631

  Fly   691 VSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANF------ISTFFRILGWARPEWSFLIIGAI 749
                .:::|..   |.:::..::||.|..:...|..      .|....|:.:.|.|:..|.|..:
Worm   632 ----SHSDFPS---NEISHQKIDQEDDYVKKLIAEIKEEGAKKSNICEIIKYCRSEYCILFIAVL 689

  Fly   750 CAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGV 814
            .:.:.|:..|:.|.::.:.|.:.|...| |:|.:|...|:..|.:.....:..:.|.:||.....
Worm   690 GSAIQGIYYPLSSQLMIKSYEAYAFDKD-EMLSKSHFWALSILFLAFTRPIFIFFQYYFFGKTAE 753

  Fly   815 WLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSI 879
            .|:.::||.:|:.:|:....::|...::...||.||:.|:::|..|:...|.::|......:.::
Worm   754 KLSIKLRSMSFKHLMSLPCAFYDDPCHTATRLSNRLNADSSNVTAAVDDRLGSVIMTLVAILLAV 818

  Fly   880 AIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRR 944
            .::|.|||:::|..|...|.:..:......|.:::..::....|:::|.|.|.:..:|||..|..
Worm   819 IMSFFYSWKMSLQVLMFCPLLYLAGYCNDNFVDQAVEEDSIAFEKSNRAAIEALENVRTVRALNM 883

  Fly   945 EEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKI----KFET 1005
            |..:|.:....:::.|:....|...:|..|....|..||.|||:..:|..:....:|    .:..
Worm   884 ENRVILLVTSHLQKIRNSYFKRAVIQGTANGFACSCYFFIYAVSFKFGTWLVLREEILPMDTYLV 948

  Fly  1006 IMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTN 1070
            :|.:|.|..|.    ..::|:.|....|:.:|..::.:. ..|.|...:|         :..|.|
Worm   949 LMTLSMTASYA----GSAVAYLPDHRKAIHAAGLIFHLF-TYPAIMPYDS---------SQGKRN 999

  Fly  1071 VVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKI 1135
            :....:..:.::|.|..|....:|...:|.:..|:|:||||.|||||||.:.||.|:|...:|::
Worm  1000 IKNGEIELKNVSFEYAQRSDKMILDGVSLKLPAGRTLALVGPSGSGKSTIISLLERFYHAVDGEV 1064

  Fly  1136 LIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFI 1200
            .||:|:: .|::|..||..:.:|||||.||..||.:|..:| .|......:|.:|.|:|||..|:
Worm  1065 KIDEENV-VDVNLHHLRESVSLVSQEPVLFNCSIKENFLFG-ISHNASQLEIDQALKVANAFSFV 1127

  Fly  1201 MSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACS 1265
            ...|...||::|.:|.|||||||||||||||::||||:|||||||||||..||:|||.|||:|..
Worm  1128 SQFPQGLDTLVGERGAQLSGGQKQRIAIARAILRNPKVLLLDEATSALDSDSEKVVQNALDTASE 1192

  Fly  1266 GRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYRCQ 1316
            ..:.:|:||||||:.||:.|.|::.||:.|||:|.:||.|..||.:|.:.|
Worm  1193 RLSTVVVAHRLSTVVNADSIAVLKNGKVAEQGTHEELLRKRSIYWRLVQKQ 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	414/1258 (33%)
		ABC_membrane	<147..333	CDD:279056	51/197 (26%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	126/234 (54%)
		ABC_membrane	749..1019	CDD:279056	63/273 (23%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	116/239 (49%)
pgp-5	NP_001257116.1	PTZ00265	27..1241	CDD:240339	422/1282 (33%)
		ABC_membrane	41..322	CDD:294371	76/306 (25%)
		ABC_MTABC3_MDL1_MDL2	374..611	CDD:213216	127/236 (54%)
		ABC_membrane	688..955	CDD:294371	61/267 (23%)
		ABC_MTABC3_MDL1_MDL2	1005..1243	CDD:213216	116/239 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2081
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880