Protein Alignment CG10226 and pgp-10

DIOPT Version :10

• Sequence 1: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Sequence 2: NP_509205.2
• Gene: pgp-10 / 180981
• WormBaseID: WBGene00004004
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1377
• Identity: 397/1377 - (28%)
• Similarity: 683/1377 - (49%)
• Gaps: 154/1377 - (11%)

  Fly    24 KKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQ 88
            |...:|.|......|..|:.:....|..::..|..:|.|||.:.|...::....|::.|.|..|:
 Worm    68 KSSDSKPKLGFFEPYKRLYAFADSIDMQLMAMGLFSALLQSALPPFVWLIMGNFVSISILREEGK 132

  Fly    89 GTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAF-NRLA- 151
                  :||      |.|| :.|..:.|.....:.:|..::.|:..:       ::.|| .|:|
 Worm   133 ------LGL------KNLT-SDYPIDDQFAHSATPAFISMLGLSIAM-------FIAAFCQRIAW 177

  Fly   152 ----LKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVI 212
                ::...|:::.:.:..|..:|.|.:..:..:.|..:.::.:.|.:||:::|...|.|:..::
 Worm   178 EISSIRQVFRIKKAYIRKLLLMDISWLESRQSGHVAAMLQESADSIYNGISDHLPMVVFILSYLL 242

  Fly   213 ISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVA 277
            :::.:.....|.:.|.:...|||.::.....:.:......:|.....:.:::|.|....|.||::
 Worm   243 VNIGVCLYIQWDVTLFMCLAIPLLIISRILYSKWFANTMEEETKLQNKITNLVNETFNCITTVIS 307

  Fly   278 FGGERSE-------SLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYY 335
            |..::.:       |..:..|.:..|::..   .|..|:..::..::|   .|:..||   |...
 Worm   308 FAAQKQKINKFEKLSAEHSKLTEERLRSSV---VFDSLTQILLTELIF---TGALCYG---IWRV 363

  Fly   336 RDPSIPIDEREYTPAVVMI--VISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLID- 397
            .|.|   ..|....|:.|:  .::.|.:..:....|        .|:.:|..|.:|::....|:
 Worm   364 ADNS---PGRLCALAINMLYMCVTSISIGFHMNGAT--------RAKDNAKEICEVLNEQPKIEV 417

  Fly   398 ------------PLSKA---GKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVAL 447
                        |:::.   .:.:.:..|||:.|||:.|.||:|::..||||::..||.|:.:|:
 Worm   418 ELASIDNNIDYVPVTRCKYRRQSMKFMGKGALHFRDIHFSYPSRKETEVLRGISFKVEAGEKIAI 482

  Fly   448 VGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRH 512
            ||.||.||||...||.|||||..|.:|||||:::......||...::|.||||||.|:|.:|||:
 Worm   483 VGSSGSGKSTLTALLLRFYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGTISDNIRY 547

  Fly   513 GKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLD 577
            |:.:|||:|:.|||:...|..||.:|..|..|.:.|:|.||||||:||:|||||:|::|.:|:.|
 Worm   548 GRLDATQQEINDAARKVGAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLIFD 612

  Fly   578 EATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELM-KLE 641
            |||||||...|:.|.||:|.|.:|.||:.::||||.|:::.||:.:..||.||:|..:||: ...
 Worm   613 EATSALDNIHEEEVNAAIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDELIADAN 677

  Fly   642 GFYHKMVTVHSYDDSAEELLNELEEVAEIK------ERKMSYEVEP------------------- 681
            |.:|||..    |...::|..:.:::.:.:      :::||:...|
 Worm   678 GIFHKMYN----DQRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARSSLGGN 738

  Fly   682 YQLGTRNSIVSLEK--------------NAEFQMKNLNGLANITMNQEI--DDPRVPSANFISTF 730
            .:||...|:.|:||              ..:::...::.: ::..:.:.  ||..:|......|.
 Worm   739 KKLGKSYSVNSMEKEKLKLPVMSKKKSERLDYKYSKVHSM-DVKQHTDSMHDDDDLPGKETNFTV 802

  Fly   731 FRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAK----PTDEEVLEQSASMAIIS 791
            .:.|.::......|:.|||..   .:...||.:::.....|:.:    |.:|..|:.....||.:
 Worm   803 LKDLIYSYRTGLPLLAGAIPT---TIVRAVFYLLICFQVASVLEISIAPDEERALQIFIVAAIYT 864

  Fly   792 LVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAAS 856
            .:| |...:...:...|..|.|......||::.||.::.....:||.:.||.|.|..::..::::
 Worm   865 ALI-IVKTIFEALGRIFIALYGHGFCKFMRNEMFRKVLRHGAAYFDEERNSPGRLVHKVINESST 928

  Fly   857 VQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEV 921
            :...:...|..:|......:.||..|...:|::||:|....|......:.:.|.|.|   :::::
 Worm   929 LNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLCSFQFPAYFVIRILQIREGTK---RQRQM 990

  Fly   922 LEE---TSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFF 983
            ::|   .:.:|:..:..:.|:.....:.....::...::.....:..:.....||.:...|..:.
 Worm   991 VDEEKKAANLASVVLANMSTIKAYNLQSHFYNVFCDALKPVSQCMQKQSLISALVFACQYSFTYI 1055

  Fly   984 GYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKP 1048
            ..|:||.:|..|....:|.....|::.....:|....:|.:|....|..|.::|..:..:| |:|
 Worm  1056 LIAITLHFGKVMMLANEISVFDYMRVVLLTQFGANFFSQLIASVSDFTKAQIAAENVMRVI-REP 1119

  Fly  1049 QIQ----SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVAL 1109
            .:.    |.|....:..||            :..:.::|.|||||.:.||.|.||.:..|:::||
 Worm  1120 PVDMDNLSEEGLRPKLEGN------------LCLKDVSFRYPSRPIVPVLTNLNLKVRGGESIAL 1172

  Fly  1110 VGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIG 1174
            ||.||||||:.:.|..|.|:..:|.::||:.:| ..::...|||.:..|.|||.||..:|.:||.
 Worm  1173 VGPSGSGKSSVISLFQRMYNATDGVVIIDKYNI-KSINPAYLRRCIVQVGQEPDLFSFTIKENIA 1236

  Fly  1175 YGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKIL 1239
            :|....:..:.::|||||:|:.|.||.|||..|||.:|..|.|||||||||||||||::|.|.:|
 Worm  1237 FGMMESEATIDKVIEAAKIADIHNFITSLPQGYDTEVGEFGAQLSGGQKQRIAIARAIIRKPTVL 1301

  Fly  1240 LLDEATSALDFQSERVVQQALD----SACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHS 1300
            ||||||||||..|||.||.|.:    |..:..|||.||||||||:|.:.|.||..|:|.|:|||.
 Worm  1302 LLDEATSALDSASEREVQNAFERVKRSTKTQCTCIQIAHRLSTIRNVDKIYVIVHGEIAEEGSHE 1366

  Fly  1301 QLLAKNGIYSKL 1312
            ||:...|||.::
 Worm  1367 QLINLKGIYYEM 1378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	169/536 (32%)
		MdlB	723..1320	CDD:440747	188/605 (31%)
pgp-10	NP_509205.2	MdlB	76..687	CDD:440747	192/654 (29%)
		MdlB	796..1378	CDD:440747	188/602 (31%)