DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and pgp-10

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_509205.2	Gene:	pgp-10 / 180981	WormBaseID:	WBGene00004004	Length:	1382	Species:	Caenorhabditis elegans

Alignment Length:	1377	Identity:	397/1377 - (28%)
Similarity:	683/1377 - (49%)	Gaps:	154/1377 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQ 88
            |...:|.|......|..|:.:....|..::..|..:|.|||.:.|...::....|::.|.|..|:
Worm    68 KSSDSKPKLGFFEPYKRLYAFADSIDMQLMAMGLFSALLQSALPPFVWLIMGNFVSISILREEGK 132

  Fly    89 GTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAF-NRLA- 151
                  :||      |.|| :.|..:.|.....:.:|..::.|:..:       ::.|| .|:|
Worm   133 ------LGL------KNLT-SDYPIDDQFAHSATPAFISMLGLSIAM-------FIAAFCQRIAW 177

  Fly   152 ----LKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVI 212
                ::...|:::.:.:..|..:|.|.:..:..:.|..:.::.:.|.:||:::|...|.|:..::
Worm   178 EISSIRQVFRIKKAYIRKLLLMDISWLESRQSGHVAAMLQESADSIYNGISDHLPMVVFILSYLL 242

  Fly   213 ISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVA 277
            :::.:.....|.:.|.:...|||.::.....:.:......:|.....:.:::|.|....|.||::
Worm   243 VNIGVCLYIQWDVTLFMCLAIPLLIISRILYSKWFANTMEEETKLQNKITNLVNETFNCITTVIS 307

  Fly   278 FGGERSE-------SLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYY 335
            |..::.:       |..:..|.:..|::..   .|..|:..::..::|   .|:..||   |...
Worm   308 FAAQKQKINKFEKLSAEHSKLTEERLRSSV---VFDSLTQILLTELIF---TGALCYG---IWRV 363

  Fly   336 RDPSIPIDEREYTPAVVMI--VISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLID- 397
            .|.|   ..|....|:.|:  .::.|.:..:....|        .|:.:|..|.:|::....|:
Worm   364 ADNS---PGRLCALAINMLYMCVTSISIGFHMNGAT--------RAKDNAKEICEVLNEQPKIEV 417

  Fly   398 ------------PLSKA---GKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVAL 447
                        |:::.   .:.:.:..|||:.|||:.|.||:|::..||||::..||.|:.:|:
Worm   418 ELASIDNNIDYVPVTRCKYRRQSMKFMGKGALHFRDIHFSYPSRKETEVLRGISFKVEAGEKIAI 482

  Fly   448 VGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRH 512
            ||.||.||||...||.|||||..|.:|||||:::......||...::|.||||||.|:|.:|||:
Worm   483 VGSSGSGKSTLTALLLRFYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGTISDNIRY 547

  Fly   513 GKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLD 577
            |:.:|||:|:.|||:...|..||.:|..|..|.:.|:|.||||||:||:|||||:|::|.:|:.|
Worm   548 GRLDATQQEINDAARKVGAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRKPIVLIFD 612

  Fly   578 EATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELM-KLE 641
            |||||||...|:.|.||:|.|.:|.||:.::||||.|:::.||:.:..||.||:|..:||: ...
Worm   613 EATSALDNIHEEEVNAAIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPDELIADAN 677

  Fly   642 GFYHKMVTVHSYDDSAEELLNELEEVAEIK------ERKMSYEVEP------------------- 681
            |.:|||..    |...::|..:.:::.:.:      :::||:...|
Worm   678 GIFHKMYN----DQRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARSSLGGN 738

  Fly   682 YQLGTRNSIVSLEK--------------NAEFQMKNLNGLANITMNQEI--DDPRVPSANFISTF 730
            .:||...|:.|:||              ..:::...::.: ::..:.:.  ||..:|......|.
Worm   739 KKLGKSYSVNSMEKEKLKLPVMSKKKSERLDYKYSKVHSM-DVKQHTDSMHDDDDLPGKETNFTV 802

  Fly   731 FRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAK----PTDEEVLEQSASMAIIS 791
            .:.|.::......|:.|||..   .:...||.:::.....|:.:    |.:|..|:.....||.:
Worm   803 LKDLIYSYRTGLPLLAGAIPT---TIVRAVFYLLICFQVASVLEISIAPDEERALQIFIVAAIYT 864

  Fly   792 LVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAAS 856
            .:| |...:...:...|..|.|......||::.||.::.....:||.:.||.|.|..::..::::
Worm   865 ALI-IVKTIFEALGRIFIALYGHGFCKFMRNEMFRKVLRHGAAYFDEERNSPGRLVHKVINESST 928

  Fly   857 VQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEV 921
            :...:...|..:|......:.||..|...:|::||:|....|......:.:.|.|.|   :::::
Worm   929 LNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLCSFQFPAYFVIRILQIREGTK---RQRQM 990

  Fly   922 LEE---TSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFF 983
            ::|   .:.:|:..:..:.|:.....:.....::...::.....:..:.....||.:...|..:.
Worm   991 VDEEKKAANLASVVLANMSTIKAYNLQSHFYNVFCDALKPVSQCMQKQSLISALVFACQYSFTYI 1055

  Fly   984 GYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKP 1048
            ..|:||.:|..|....:|.....|::.....:|....:|.:|....|..|.::|..:..:| |:|
Worm  1056 LIAITLHFGKVMMLANEISVFDYMRVVLLTQFGANFFSQLIASVSDFTKAQIAAENVMRVI-REP 1119

  Fly  1049 QIQ----SPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVAL 1109
            .:.    |.|....:..||            :..:.::|.|||||.:.||.|.||.:..|:::||
Worm  1120 PVDMDNLSEEGLRPKLEGN------------LCLKDVSFRYPSRPIVPVLTNLNLKVRGGESIAL 1172

  Fly  1110 VGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIG 1174
            ||.||||||:.:.|..|.|:..:|.::||:.:| ..::...|||.:..|.|||.||..:|.:||.
Worm  1173 VGPSGSGKSSVISLFQRMYNATDGVVIIDKYNI-KSINPAYLRRCIVQVGQEPDLFSFTIKENIA 1236

  Fly  1175 YGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKIL 1239
            :|....:..:.::|||||:|:.|.||.|||..|||.:|..|.|||||||||||||||::|.|.:|
Worm  1237 FGMMESEATIDKVIEAAKIADIHNFITSLPQGYDTEVGEFGAQLSGGQKQRIAIARAIIRKPTVL 1301

  Fly  1240 LLDEATSALDFQSERVVQQALD----SACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHS 1300
            ||||||||||..|||.||.|.:    |..:..|||.||||||||:|.:.|.||..|:|.|:|||.
Worm  1302 LLDEATSALDSASEREVQNAFERVKRSTKTQCTCIQIAHRLSTIRNVDKIYVIVHGEIAEEGSHE 1366

  Fly  1301 QLLAKNGIYSKL 1312
            ||:...|||.::
Worm  1367 QLINLKGIYYEM 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	384/1317 (29%)
		ABC_membrane	<147..333	CDD:279056	35/198 (18%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	117/235 (50%)
		ABC_membrane	749..1019	CDD:279056	51/276 (18%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	120/241 (50%)
pgp-10	NP_509205.2	MdlB	73..687	CDD:224055	194/657 (30%)
		ABC_membrane	156..381	CDD:294371	44/243 (18%)
		ABC_MTABC3_MDL1_MDL2	450..687	CDD:213216	117/240 (49%)
		ABC_membrane	823..1099	CDD:294371	52/282 (18%)
		MdlB	825..1382	CDD:224055	182/572 (32%)
		P-loop_NTPase	1141..1381	CDD:304359	120/239 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.890