DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10226 and haf-3

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_506927.2	Gene:	haf-3 / 180056	WormBaseID:	WBGene00001813	Length:	666	Species:	Caenorhabditis elegans

Alignment Length:	671	Identity:	205/671 - (30%)
Similarity:	335/671 - (49%)	Gaps:	86/671 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   667 VAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSANFISTFF 731
            |:.::.::.||:::........:|:||.  ..::.:.:.|::.:.::..|         |:.| .
Worm    53 VSVVETKRESYKLKNASWKDLKAILSLA--GPYKWRIMLGISFLGISSSI---------FLFT-P 105

  Fly   732 RILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVL------EQSASMAII 790
            |:||....||.                        |.......|.|:.:|      |...::|.:
Worm   106 RVLGKLIDEWD------------------------ETKQDKMDPNDKALLLARFFKENPIALAGV 146

  Fly   791 SLV--IGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGD 853
            .::  |.|||.:.|      .:.||..:...:|...|..::.|:|.:||:  |.:|.:.:|||.|
Worm   147 FMLGAIAIAARIYC------MHTAGQLVINDLRKSVFNSVLRQDMAFFDK--NKVGEIVSRLSTD 203

  Fly   854 AASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKE 918
            |..|..::...||:..:|......|..:....|..:..:.....|.:|.:.....:...|..|..
Worm   204 ALIVGYSVSMNLSDGARALITCFGSGGLMVYTSLAMCKVIFVVVPVIVGTFAVFGKLQRKYTLMM 268

  Fly   919 KEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNS-LGKSLMF 982
            :|.:...:::|||.::.:|||..|..|.:.:..|..::    ::|....|..||... :..|..|
Worm   269 QEAVAGANQVATERLSSVRTVRMLVAERKELAAYSDKI----NEIWQISKKEGLAKGFMFGSFQF 329

  Fly   983 FGY---AVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALL----SANRM 1040
            .||   :..|.||.::.:.|.:   |..::|:..||.: :.|.||:....|...|:    :::|:
Worm   330 TGYLALSSILFYGSNLISQGLL---TYGELSSFCLYAV-LSAGSLSAMSGFYLELMKGLGASSRL 390

  Fly  1041 YEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQ 1105
            :|:.:|:|:|......:|   ||        |:..:.:..:.|.|..|.  .:..|.:.|:..|:
Worm   391 FELKNREPRIPLEGGVQI---GN--------VKDTIRFEHVAFGYADRD--PLFHNISFDVPAGK 442

  Fly  1106 TVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIA 1170
            ..|:||:|||||||...||:|.|||..|:||:|...: .|:|....||.:|.|.|||.||..:|.
Worm   443 ITAVVGSSGSGKSTIASLLLRLYDPTSGRILVDGTDL-KDIDPSYWRRHIGTVGQEPVLFSTTIK 506

  Fly  1171 DNIGYGDTS-RQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVR 1234
            :||.||... ..|...:|:.||..:||.|||...|.:|||.:|..|:.||||||||||||||:|.
Worm   507 ENIIYGSLEPENVTDAEIVSAADQSNADEFISRFPIKYDTKVGEHGSTLSGGQKQRIAIARALVN 571

  Fly  1235 NPKILLLDEATSALDFQSERVVQQALDS--ACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQG 1297
            .|.||::||||||||..||.:|:.||:.  |.|.:|.::||||||||::|:.|.|:..|.:.|.|
Worm   572 KPNILIMDEATSALDASSEYLVRIALNKLLANSKQTVMIIAHRLSTIKHADQIVVVDRGSVAESG 636

  Fly  1298 SHSQLLA-KNGIYSKLYRCQT 1317
            |:.:|:| .:||:.||...||
Worm   637 SYDELIAIPDGIFRKLVEKQT 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	201/663 (30%)
		ABC_membrane	<147..333	CDD:279056
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216
		ABC_membrane	749..1019	CDD:279056	62/281 (22%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	112/243 (46%)
haf-3	NP_506927.2	MdlB	70..657	CDD:224055	200/652 (31%)
		ABC_membrane	96..366	CDD:279056	70/319 (22%)
		P-loop_NTPase	415..656	CDD:304359	112/243 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910