DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and haf-1

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_503098.2	Gene:	haf-1 / 178522	WormBaseID:	WBGene00001811	Length:	677	Species:	Caenorhabditis elegans

Alignment Length:	640	Identity:	188/640 - (29%)
Similarity:	316/640 - (49%)	Gaps:	88/640 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 NITMNQEIDDPRVPSANFISTFFRILGW---------ARP--EWSFLIIGAICAGLYGVTMPVFS 762
            |..:||.|  .||...| .:...|...|         |:|  :|.||          |.:..|.|
Worm    44 NQKLNQNI--RRVDRRN-AAYLLRHTTWKDLVELYEIAKPFRKWIFL----------GTSFMVVS 95

  Fly   763 ----VVLAELYGSLAKPTD--------EEVLEQSAS-------MAIISLV----IGIAAGVVCYI 804
                :::..:.|.|....|        |||.....:       |:::.|:    :..||.|.|
Worm    96 SGIFLIIPRILGKLIDQFDSNTGVQKAEEVFTMKIAKYFKEQPMSLVGLLAIGALATAAKVYC-- 158

  Fly   805 QTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNII 869
                ..:|||.:...:|...:..|:.|:|.:||:  |.:|.:.:|.:.|...|..::...|...:
Worm   159 ----LQIAGVNIVGSLRKMVYSSIIRQDMTFFDK--NMVGEIGSRHAADTVIVGYSVSSSLRAGV 217

  Fly   870 QAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETIT 934
            :|....:.||.:....|.||:.:...|:|.::.......|..::...:.:||..:.::.|.|.:.
Worm   218 RAVLVGVGSIGMMLMTSLELSTVSFLTAPIVMGIFKMFGRVQQQCTWQLQEVAADVNQTAIERMA 282

  Fly   935 QIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLV-NSLGKSLMFFGYAV---TLTYGGHM 995
            .::|:..|..|::.|..|.|:.|    .:|...|...|. .||..|..|.||:.   .|.||.|:
Worm   283 NMKTIRMLSAEQQSIDEYCKKGE----LVLDISKTEALAKGSLIGSFQFTGYSAFSSILFYGSHL 343

  Fly   996 CADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALL----SANRMYEIIDRKPQIQSPESF 1056
            ...|.|   |..::|:..||.: :.|.||:....|...::    :::|:.|:.:.:|.:
Worm   344 INTGHI---TYGELSSFCLYAV-LAAASLSNISGFYNEVMKGLGASSRLLELKNAQPIM------ 398

  Fly  1057 EIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCV 1121
                |.|....||::. ..:.:..::|:|..|.  |.|:|.:.||.:|:..|::|.||||||:..
Worm   399 ----NLNSGIKKTDIT-TSIQFENVSFAYAGRK--KTLENISFDIPRGKITAVIGPSGSGKSSIA 456

  Fly  1122 QLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYG-DTSRQVPMQ 1185
            .|::|.|||.:|::.:|...: .|::..|.|..:|.|.|||.||..||.:||..| :...:|...
Worm   457 NLMLRLYDPADGRVTVDGVDL-RDLNATTWRHAIGTVGQEPVLFTCSIRENILMGTEHPEKVSQY 520

  Fly  1186 QIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDF 1250
            ::.|||::|||.:||......::|::|..|.:||||||||||||||::..|||::|||||||||.
Worm   521 ELEEAAQLANALDFIQGFENGFETMVGEHGCKLSGGQKQRIAIARALISKPKIMILDEATSALDA 585

  Fly  1251 QSERVVQQALDSACSGR--TCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLL 1303
            .|:.:::..||:.....  |.:||||||:|:|.|:.:..:..|:|..||:..:::
Worm   586 TSDYLIRMTLDNLLKNHNLTVLVIAHRLATMQQADQVVYVNRGRIEGQGTFDEMM 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	188/640 (29%)
		ABC_membrane	<147..333	CDD:279056
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216
		ABC_membrane	749..1019	CDD:279056	69/296 (23%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	94/231 (41%)
haf-1	NP_503098.2	MdlB	82..641	CDD:224055	177/599 (30%)
		ABC_membrane	93..363	CDD:294371	68/285 (24%)
		P-loop_NTPase	413..641	CDD:304359	94/231 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910