DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and haf-6

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_490828.3	Gene:	haf-6 / 171694	WormBaseID:	WBGene00001816	Length:	668	Species:	Caenorhabditis elegans

Alignment Length:	657	Identity:	209/657 - (31%)
Similarity:	327/657 - (49%)	Gaps:	91/657 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KTKEKAQPMVSYTELFRYIA---GWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLGQ 88
            :|.|.....::..||:..|.   ||.:..::...::|:: ::..|:.               ||.
Worm    73 RTTEDQNASMTAGELWNLIKPFFGWFFAAVVCAILSAYI-NIQIPLC---------------LGD 121

  Fly    89 GTSSVTIGLSLFGGGKILTNAS--YEENMQELRKDSVSFGILMTL----NTLLMLFSGVYYVDAF 147
            ..:.:.         ||:.:.|  ...:.::|:..::.   ||||    :.|..|     |:...
Worm   122 LVNGIV---------KIIKDESNNLRSHFEQLKPSALH---LMTLYVAQSALTFL-----YITFL 169

  Fly   148 NRLALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVI 212
            ..|..::..:||.:.|:..|..::.:.|..|....:.|:..::::.:|.....:...:......|
Worm   170 TVLGERMATKMRSDLFQKLLHHDMAFFDSHKSGELSARLNADVQEFKSSFKLCVSQGLRTFAQTI 234

  Fly   213 ISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVA 277
            ..:...:.....:.:..|..:|..::..||:.....:|:.:.|.....||:|.:|.:..|||:.|
Worm   235 GCIGSLYFLSPTMTMYTVAVVPGIILAGSAIGAGLRQLSRRAQGQSATASAVSDEALTNIRTIRA 299

  Fly   278 FGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPI 342
            |..|:.||..:|:.|..|....:..|...|         ||..|...|..|..|.:.|...:: |
Worm   300 FAMEKLESRLFDNELDKARAMQEQLGVGIG---------LFQAGTNLFLNGMILSVLYGGSNL-I 354

  Fly   343 DEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILN 407
            .:.|.||..:|    ..:|||..|.|:   |...::..|:|            |...:..|::|.
Worm   355 SKGEMTPGALM----SFLVSAQTIQRS---LSQLSIIFGTA------------IKGWTAGGRVLQ 400

  Fly   408 Y------------------GLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCG 454
            :                  .|.|.::|.||.|.||.|....|...|.:.:..||.|||.||||.|
Worm   401 FSRLEPSIPMDTGVCIPYHSLWGDIKFEDVSFSYPTRPGHTVFENLTLSIPAGQVVALCGPSGEG 465

  Fly   455 KSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSN-IAVVGQEPVLFQGSIGENIRHGKPEAT 518
            |||...||:|||:|..|:|.|||.|:|:.|::|||.. |.::.||||||..|:.||||:|:|:||
Worm   466 KSTITHLLERFYEPKSGRVTLDGRDLRELNVEWLRGQVIGLISQEPVLFATSVEENIRYGRPDAT 530

  Fly   519 QKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSAL 583
            .:||.:||:||:..:|:.....||.|.:.|:|.||||||:||||||||:::.|.||:||||||||
Worm   531 DEEVREAARAAHVDEFVSRFPSGYSTVVGERGAQLSGGQKQRIAIARAILKNPPILILDEATSAL 595

  Fly   584 DYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEG-FYHKM 647
            |.|||.:||.||:...||||.|:::||||.||.|..|..|::.||:|.||||:||..:| .|.|:
Worm   596 DSHSEHMVQEALNNVMKGRTVLIIAHRLSTIRSAQMIYVIKDKKALESGTHEQLMAKKGSLYRKL 660

  Fly   648 VTVHSYD 654
            |..|:.|
Worm   661 VEAHNVD 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	200/600 (33%)
		ABC_membrane	<147..333	CDD:279056	39/185 (21%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	126/236 (53%)
		ABC_membrane	749..1019	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216
haf-6	NP_490828.3	MdlB	87..663	CDD:224055	204/637 (32%)
		ABC_membrane	102..378	CDD:279056	65/325 (20%)
		ABC_MTABC3_MDL1_MDL2	425..663	CDD:213216	127/237 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910