DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and Abcb1a

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_596892.1	Gene:	Abcb1a / 170913	RGDID:	619951	Length:	1272	Species:	Rattus norvegicus

Alignment Length:	1325	Identity:	526/1325 - (39%)
Similarity:	791/1325 - (59%)	Gaps:	67/1325 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ETREDVPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGW-DYLVLLSGFVAAFLQSLVFP 68
            |..||:........:...:|.||.|::.:|.||...:||| ||| |...:|.|.:||.:..:..|
  Rat     2 ELEEDLNGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRY-AGWLDRFYMLLGTLAAIIHGIALP 65

  Fly    69 IAIVVYSELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNT 133
            :.::|:.::...|  ..:|...|     :|.:....|......|..........:..|:|:....
  Rat    66 LMMLVFGDMTDSF--ANVGNNRS-----MSFYNATDIYAKLEDEMTTYAYYYTGIGAGVLIVAYI 123

  Fly   134 LLMLFSGVYYVDAFNRLALKLTV-RMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGI 197
            .:.|:.          ||....: ::|::||.|.:.|||||.|:........|:||::.||..||
  Rat   124 QVSLWC----------LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGI 178

  Fly   198 AENLGHYVEIMCDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRAS 262
            .:.:|.:.:.|.......::.|..||||.|.|:...|:..:.....|......|.:|..:|.:|.
  Rat   179 GDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAG 243

  Fly   263 SVVEEVIGAIRTVVAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWY 327
            :|.|||:.|||||:||||::.|..||::.|:.|.:.|..|...:.:|......:::.:.|.:|||
  Rat   244 AVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWY 308

  Fly   328 GANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDR 392
            |.:|::          .:|||...|:.|...:::.|..:.:.||.:|.||.|||:|..:..:||.
  Rat   309 GTSLVI----------SKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDN 363

  Fly   393 TSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKST 457
            ...||..||:|...: .::|.:||:::.|.||:|:||.:|:|||:.|:.||||||||.|||||||
  Rat   364 KPSIDSFSKSGHKPD-NIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKST 427

  Fly   458 CIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEV 522
            .:|||||.|||:.|:|.:||:|:|..|:::||..|.||.||||||..:|.||||:|:...|..|:
  Rat   428 TVQLLQRLYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEI 492

  Fly   523 EDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHS 587
            |.|.|.|||:|||:.|...:||.:.|:|.||||||:|||||||||::.||||||||||||||..|
  Rat   493 EKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTES 557

  Fly   588 EKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHS 652
            |.:||||||||.:||||:|::||||.:|:|..|...:.|..||||.|:|||:.:|.|.|:|...:
  Rat   558 EAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQT 622

  Fly   653 YDDSAEELLNELE---EVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGL----ANI 710
            ..       ||:|   |..|.|:     .::...:.:::|..||.:....: |::.|.    ..:
  Rat   623 AG-------NEIELGNEACESKD-----GIDNVDMSSKDSGSSLIRRRSTR-KSIRGPHDQDGEL 674

  Fly   711 TMNQEIDDPRVPSANFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKP 775
            :..:.:||. ||.|    :|:|||.....||.:.::|..||.:.|...|.||::.:::.|...|.
  Rat   675 STKEALDDD-VPPA----SFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKN 734

  Fly   776 TDEEVLEQSASM-AIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRK 839
            ...|:..|:::: :::.|::||.:.:..::|.|.|..||..||.|:|...|:.::.|::.|||..
  Rat   735 DTPEIQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDP 799

  Fly   840 ENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASI 904
            :|:.|||:.||:.|||.|:||.|..|:.|.|...|....|.|:..|.|:|.|:.|:..|.:..:.
  Rat   800 KNTTGALTTRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAG 864

  Fly   905 VFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKW 969
            |.|.:.....|||:|:.||.:.:||||.|...|||..|.||::...:|.:.::......|.:...
  Rat   865 VVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHV 929

  Fly   970 RGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAAL 1034
            .|:..|..:::|:|.||....:|.::.|...:.||.::.:.:.:::|...:.|..:|.|.:..|.
  Rat   930 FGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAK 994

  Fly  1035 LSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNL 1099
            :||:.:..||::.|:|.|..:         ...|.|:::..|.:.|:.|:||:||:|.|||..:|
  Rat   995 VSASHIIRIIEKIPEIDSYST---------EGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSL 1050

  Fly  1100 DINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSL 1164
            ::.:|||:||||:||.||||.||||.|:|||..|.:.:|.:.| ..::::.||..||||||||.|
  Rat  1051 EVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGTVFLDGKEI-KQLNVQWLRAHLGIVSQEPIL 1114

  Fly  1165 FEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIA 1229
            |:.|||:||.|||.||.|..::|::|||.||.|:||.|||.:|:|.:|.||||||||||||||||
  Rat  1115 FDCSIAENIAYGDNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIA 1179

  Fly  1230 RAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIV 1294
            ||:||.|.||||||||||||.:||:|||:|||.|..|||||||||||||||||::|.|||.|::.
  Rat  1180 RALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVK 1244

  Fly  1295 EQGSHSQLLAKNGIYSKLYRCQTKA 1319
            |.|:|.||||:.|||..:...|..|
  Rat  1245 EHGTHQQLLAQKGIYFSMVSVQAGA 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	501/1238 (40%)
		ABC_membrane	<147..333	CDD:279056	61/186 (33%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	139/234 (59%)
		ABC_membrane	749..1019	CDD:279056	84/270 (31%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	148/239 (62%)
Abcb1a	NP_596892.1	PTZ00265	51..1259	CDD:240339	505/1263 (40%)
		ABC_membrane	54..335	CDD:279056	79/307 (26%)
		ABC_MTABC3_MDL1_MDL2	385..621	CDD:213216	140/235 (60%)
		ABC_membrane	707..978	CDD:279056	84/270 (31%)
		ABC_MTABC3_MDL1_MDL2	1027..1266	CDD:213216	148/239 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910