DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10226 and ABCB8

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001269220.1	Gene:	ABCB8 / 11194	HGNCID:	49	Length:	735	Species:	Homo sapiens

Alignment Length:	669	Identity:	230/669 - (34%)
Similarity:	345/669 - (51%)	Gaps:	89/669 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VPAADADEATPAAQKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVY 74
            |...:|:||.||:         :.|.|..:. |.:...|.:|         ....||..:|:|
Human   110 VALCEAEEAPPAS---------STPHVVGSR-FNWKLFWQFL---------HPHLLVLGVAVV-- 153

  Fly    75 SELVAMFIERTLGQGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMT----LNTLL 135
                       |..|.:.|.:.:.|..|..:...|.|       .:|.|  |..||    |:|.|
Human   154 -----------LALGAALVNVQIPLLLGQLVEVVAKY-------TRDHV--GSFMTESQNLSTHL 198

  Fly   136 MLFSGVYYVDAFNRLAL------KLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIR 194
            ::..||..:..|..|.|      ::.|.|||..|.:.|||:|.:.|..|......|:|.::::.:
Human   199 LILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFK 263

  Fly   195 SG----IAENLGHYVEIM-CDVIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQE 254
            |.    |::.|....::. |.|.:|::.:     :|.|.::...|..:.|.:.:.....||:.|.
Human   264 SSFKLVISQGLRSCTQVAGCLVSLSMLST-----RLTLLLMVATPALMGVGTLMGSGLRKLSRQC 323

  Fly   255 QSSYVRASSVVEEVIGAIRTVVAFGGERSESLRYDSLLKP----ALKAGKWKGAFSGLSDTVMKA 315
            |....||..|.:|.:|.:|||.||..|:.|..||.:.|:.    |.:.|:....|.|||:.....
Human   324 QEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNC 388

  Fly   316 MLFITGAGSFWYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETF--AM 378
            |:.    |:.:.|.:|:.          .::.|...:|    ..:|::..:.|:...|...  .:
Human   389 MVL----GTLFIGGSLVA----------GQQLTGGDLM----SFLVASQTVQRSMANLSVLFGQV 435

  Fly   379 ARG-SASA-ILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEE 441
            .|| ||.| :.:.:.....| |||....:....|:|:|.|::|.|.||.|....||:...:.:..
Human   436 VRGLSAGARVFEYMALNPCI-PLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPP 499

  Fly   442 GQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSN-IAVVGQEPVLFQGS 505
            |:.|||||.||.||:|...||:|||||..|.|:|||.|:|..:..|||.. :..:.||||||..:
Human   500 GKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTT 564

  Fly   506 IGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQ 570
            |.||||.||.||:.:||..||:.||||:||.:..:||:|.:.|:|..|||||:||:|||||||:|
Human   565 IMENIRFGKLEASDEEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQ 629

  Fly   571 PKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHE 635
            |.:|:|||||||||..||::||.|||:|..|||.||::||||.:|.||.||.:.:|:..|.||||
Human   630 PTVLILDEATSALDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHE 694

  Fly   636 ELMKLEGFYHKMVTVHSYD 654
            ||:|..|.|.:::...:.|
Human   695 ELLKKGGLYAELIRRQALD 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	215/598 (36%)
		ABC_membrane	<147..333	CDD:279056	55/200 (28%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	126/235 (54%)
		ABC_membrane	749..1019	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216
ABCB8	NP_001269220.1	MdlB	165..713	CDD:224055	211/580 (36%)
ABCB8	NP_001269220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..735		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810