DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10226 and tap1

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_002665053.1	Gene:	tap1 / 100333043	ZFINID:	ZDB-GENE-050517-43	Length:	731	Species:	Danio rerio

Alignment Length:	661	Identity:	214/661 - (32%)
Similarity:	334/661 - (50%)	Gaps:	99/661 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSG-FVAAFLQSLVFPIAIVVYSELVAMFIERTLG 87
            ||::|::|.:     ..|.|.:.   |:...|| |.|.|.        .||.|.|..|.|....|
Zfish   136 KKERTEKKGK-----ASLQRLLG---YMKPFSGRFAAVFF--------FVVISSLGEMAIPHYTG 184

  Fly    88 QGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGV--YYVD-AFNR 149
            :.|..:                     |.|  .:..:|...:|:.||:.:.|.|  :..| .:|.
Zfish   185 KMTDWI---------------------MNE--DEPEAFNHAITVMTLMTIMSAVCEFVCDLIYNI 226

  Fly   150 LALKLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIIS 214
            ...::...::...|:|.|:|:|.:.|.|...:...|||.:...:...::|.|...:.....||
Zfish   227 TMSRIHTSIQGLVFQAVLKQDIAFFDKATTGDIVSRITTDTNTMSESLSEKLSLLMWYFMRVI-- 289

  Fly   215 VVLSFIYGWKLALA------IVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIR 273
                |::|..|.|:      .:..:|:..::......:..||:.|.|.|..:|:.|..|...:::
Zfish   290 ----FLFGSMLMLSTRLCCFTLLGLPVIWIIPEIFGRFYQKLSAQVQDSLAKANEVATETFSSMK 350

  Fly   274 TVVAFGGERSESLRYDSLLKPALKAGK----------WKGAFSGLSDTVMKAMLFITG---AGSF 325
            ||.:|..|..|:.||...|:......|          |..:.|.|:..|  ::|:..|   .||.
Zfish   351 TVRSFANEDGETERYRKCLEDTFALNKVEAAAYAVSTWTNSMSSLALKV--SILYYGGRLVTGSD 413

  Fly   326 WYGANLILYYRDPSIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVI 390
            ....:|:      |..:.|.::|.||.:::               .:......|.|::..|.:.:
Zfish   414 VSSGDLV------SFVLYELQFTSAVEVLM---------------SYWPHVKKAVGASEKIFEYV 457

  Fly   391 DRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGK 455
            ||...:.|   .|.:....|||.|:||:|.|.||.|.|..||:.:::.::.|:..|||||||.||
Zfish   458 DRKPDVPP---DGSLAPKTLKGHVQFRNVTFAYPKRPDTDVLKNVSLELKAGKITALVGPSGSGK 519

  Fly   456 STCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQK 520
            :|.:.||:|||.|..|::|||.:.:..|..::|...|:||.||||||..|:.|||::||..||.:
Zfish   520 TTVVSLLERFYQPQNGEILLDQKPLLSYKDQYLHEKISVVSQEPVLFARSVRENIKYGKENATNE 584

  Fly   521 EVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDY 585
            |:..||:.|||||||.:|.||||||..|||.|:||||:|||||||||||:|:||:||:|||:||.
Zfish   585 EIYAAARLANAHDFISSLPKGYDTDAGEKGGQVSGGQKQRIAIARALIQKPQILVLDDATSSLDT 649

  Fly   586 HSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMV-- 648
            .||..|.:||.|..:..|.|::|||||.:.:|..|:::..|:.||:|.|::|:..:|||.:.|
Zfish   650 ESEHRVYSALKKELQSCTVLLISHRLSGVENADHILFLREGELVEEGNHQQLLDKQGFYAEFVKQ 714

  Fly   649 ---TVHSYDDS 656
               .:|...|:
Zfish   715 QNTAIHRNADN 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	197/603 (33%)
		ABC_membrane	<147..333	CDD:279056	46/204 (23%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	122/239 (51%)
		ABC_membrane	749..1019	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216
tap1	XP_002665053.1	3a01208	42..712	CDD:273363	211/646 (33%)
		ABC_membrane	166..433	CDD:279056	67/311 (22%)
		P-loop_NTPase	467..692	CDD:304359	117/224 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910