DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and abcb4

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	NP_001303643.1	Gene:	abcb4 / 100136865	ZFINID:	ZDB-GENE-080204-52	Length:	1275	Species:	Danio rerio

Alignment Length:	1319	Identity:	517/1319 - (39%)
Similarity:	788/1319 - (59%)	Gaps:	98/1319 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLG 87
            :::|:.|||.: ||...|||||....|.|:::.|.:.:.....|.|:.::|:.::...|::.||.
Zfish    27 KEEKEEKEKLE-MVGPIELFRYADSIDILLMMLGLIMSMANGAVLPLMVIVFGDMTDSFVDDTLL 90

  Fly    88 QGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSG-VYYVDAFNRLA 151
            ....::|:.          .|.::.|.      .:::.|..||.:.:.....| |..|.|:.::|
Zfish    91 DNLKNITLP----------PNFTFPET------SNITLGEKMTTHAIYYSIMGFVVLVAAYMQVA 139

  Fly   152 L------KLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCD 210
            .      :...::|:.||.:.::|||||.|:.:......|:||::.||..||.:.||..::.:..
Zfish   140 FWTLAAGRQVKKLRKIFFHSIMKQEIGWFDVNETGQLNTRLTDDVYKINEGIGDKLGMLIQNLTT 204

  Fly   211 VIISVVLSFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTV 275
            .|:.:::.|..||||.|.|:...||..:..:.:.......|.:||::|.:|.:|.|||:.:||||
Zfish   205 FIVGIIIGFAKGWKLTLVILAVSPLLGISAAVIGKVMTTFTSKEQTAYAKAGAVAEEVLSSIRTV 269

  Fly   276 VAFGGERSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSI 340
            .||||::.|..||...|:.|...|..|.....::......|::::.|.:||||:.|||
Zfish   270 FAFGGQKKEIKRYHKNLEDAKNVGVRKAITVNIAMGFTFFMIYMSYALAFWYGSTLIL------- 327

  Fly   341 PIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKI 405
               ..|||..:::.:...:::.|..:.:|||.::||:.|||:|..:..:||....|:..|:.|..
Zfish   328 ---GGEYTIGMLLTIFFAVLIGAFGLGQTSPNIQTFSSARGAAHKVFQIIDHEPKINSFSEEGYK 389

  Fly   406 LNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVF 470
            |:. :||.:||:::.||||:|:||.||.|:|:.|..|||:||||.|||||||.||||||||||..
Zfish   390 LDV-VKGNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFYDPQE 453

  Fly   471 GQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFI 535
            |.|.:||.|:|..|::.||..|.||.||||||..:|.||||:|:.:.||.|:|.||:.|||::||
Zfish   454 GSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANAYNFI 518

  Fly   536 IALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACK 600
            :.|...::|.:.::|.|:||||:|||||||||::.||||||||||||||..||.:|||||||...
Zfish   519 MKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQAALDKVRL 583

  Fly   601 GRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELE 665
            ||||:||:||||.||:|..|...:||:.||.|||:|||:.:|.||.:|.:..:..:
Zfish   584 GRTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSLVNMQMFKST--------- 639

  Fly   666 EVAEIKERKMSY-EVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQE--IDDPRVPSANFI 727
            ||||....:|:. |..|       |:.|:.:...|:.|:.:|.......:|  .::.:||:.:|:
Zfish   640 EVAEEDSEEMTMDEKSP-------SVSSMNERTLFRQKSRSGSEKELKEEEKPTEEEKVPNVSFL 697

  Fly   728 STFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASM-AIIS 791
            :    :|....|||.::::|.:||.:.|...|.|:|:.:::....|:| |:.::.|...: :::.
Zfish   698 T----VLKLNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIAVFAEP-DQNLVRQRCDLYSLLF 757

  Fly   792 LVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAAS 856
            ..||:.:....::|.|.|..||..||.|:|.|.|..:|.|::.|:|..:||:|||:.||:.|.|.
Zfish   758 AGIGVLSFFTLFLQGFCFGKAGELLTMRLRFKAFNAMMRQDLAWYDDTKNSVGALTTRLAADTAQ 822

  Fly   857 VQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEV 921
            ||||.|..|:.:.|...|...:|.|:|.|.|:|.|:.||..|.|..:...:.:.....|||:|:.
Zfish   823 VQGATGVRLATLAQNVANLGTAIVISFVYGWQLTLLILSIVPIMAVAGAIQMKLLAGHALKDKKE 887

  Fly   922 LEETSRIATETITQIRTVAGLRREEELIKIYD-------KEVERYRHQILSRLKWRGLVNSLGKS 979
            ||:..:||||.|..:|||..|.||.:...:|:       |..::..|..       ||..|..::
Zfish   888 LEQAGKIATEAIENVRTVVSLTRESKFESLYEENLIVPYKNAKKKAHVF-------GLTFSFSQA 945

  Fly   980 LMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEII 1044
            :::|.||....:|..:.....:.||.:..:.:.::||...:.::.:|||.:..|.:||:.:..:|
Zfish   946 MIYFAYAGCFKFGSWLIEQKLMTFEGVFLVISAVVYGAMAVGEANSFTPNYAKAKMSASHVLMLI 1010

  Fly  1045 DRKPQIQS-------PESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDIN 1102
            :|.|.|.:       |:.||    ||            |.:..:.|.|||||.:.|||...|.:.
Zfish  1011 NRAPAIDNSSEDGDKPDKFE----GN------------VGFEHVYFKYPSRPDVPVLQGLKLRVK 1059

  Fly  1103 QGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEK 1167
            :|||:||||:||.||||.:|||.|:|||.:|::::|.... ..:::..||.::|||||||.||:.
Zfish  1060 KGQTLALVGSSGCGKSTTIQLLERFYDPQQGRVMLDDNDA-KQLNIHWLRSQIGIVSQEPVLFDC 1123

  Fly  1168 SIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAM 1232
            |:|:||.|||.||:|..::|:||||.||.|.||.:||.:|.|..|.||||||||||||||||||:
Zfish  1124 SLAENIAYGDNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAI 1188

  Fly  1233 VRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQG 1297
            :||||:|||||||||||.:||::||.|||.|..|||||::||||||||||:.|.|:|.|.:||||
Zfish  1189 LRNPKVLLLDEATSALDTESEKIVQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQG 1253

  Fly  1298 SHSQLLAKNGIYSKLYRCQ 1316
            :|.|||::.|.|..|...|
Zfish  1254 THQQLLSQQGAYYTLVTSQ 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	498/1254 (40%)
		ABC_membrane	<147..333	CDD:279056	60/191 (31%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	140/234 (60%)
		ABC_membrane	749..1019	CDD:279056	86/277 (31%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	140/239 (59%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	501/1282 (39%)
		ABC_membrane	60..348	CDD:279056	81/313 (26%)
		ABC_MTABC3_MDL1_MDL2	397..634	CDD:213216	141/236 (60%)
		ABC_membrane	714..984	CDD:279056	86/277 (31%)
		ABC_MTABC3_MDL1_MDL2	1035..1272	CDD:213216	139/237 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7260
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.830