DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and abcb10

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_001343218.3	Gene:	abcb10 / 100003744	ZFINID:	ZDB-GENE-040525-2	Length:	710	Species:	Danio rerio

Alignment Length:	644	Identity:	220/644 - (34%)
Similarity:	346/644 - (53%)	Gaps:	72/644 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   705 NGLANITMNQE------IDDPRVPSANFISTFFRILGWARPE-W------SFLIIGAICAGLYGV 756
            |..:...:|||      .|...|||.:    ..::|..|.|: |      .||:|.:.      |
Zfish    94 NQTSKSVVNQESSAKTTADSLPVPSED----VKKLLQLAHPQRWRLTAAVGFLVISST------V 148

  Fly   757 TM--PVF-SVVLAELYGSLAKPTDEEVLEQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTT 818
            ||  |.| ..|:..:|.|   || |:......|:.::...:.:..|.....:.:...::|..:..
Zfish   149 TMSAPFFLGKVIDTIYTS---PT-EDFSSSLTSLCLMLTGVFLCGGAANAARVYLMQISGQQIVR 209

  Fly   819 RMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAF 883
            ::|...|..|:.||:|:||:...  |.|..|||.|.|.|...:...||:.:::.......:.:..
Zfish   210 KLRESLFSSILKQELGFFDKTRT--GELINRLSADTAIVGRCLTDNLSDGLRSLAQAGAGVGMML 272

  Fly   884 PYSWELALICLSTSPFMVASIVFEARFGEKSALKEKEVLEETSRIATETITQIRTVAGLRREEEL 948
            ..|..||...|...|.:....|...||....:.:.::.|.|.:::|.|.|:.:|||....:|...
Zfish   273 YVSPSLAAFVLMVVPPIACLAVIFGRFLRSISRRTQDALAEATQLAEERISNLRTVRAFGKELTE 337

  Fly   949 IKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGYA--------VTLTY-GGHMCADGKIKFE 1004
            ::.|.::|:.     :..|..:..|.|.|    |:|..        :::.| ||.:.|...:
Zfish   338 VQKYSQKVDH-----IFELAKKEAVVSAG----FYGVTGLSGNVIILSVLYKGGLLMASEAM--- 390

  Fly  1005 TIMKISNTMLYGLFILAQSLAFTPAFNAALL----SANRMYEIIDRKPQIQSPESFEIQQNGNGT 1065
            |:.::|:.::|. |.:..|:|...:|.:.|:    :..|::|:|||||:....|         |.
Zfish   391 TVGQLSSFLMYA-FWVGISIAGFSSFYSELMKGLGAGTRLWELIDRKPEFPLNE---------GL 445

  Fly  1066 AYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDP 1130
            ...:.:::..:.:|.::|:||:|....:.|:.:|.:..|..:|:||:||||||:.|.||:|.|||
Zfish   446 VLTSELLKGELEFRNVSFAYPTRKDSPIFQDLSLHVPAGSVLAVVGSSGSGKSSLVSLLLRLYDP 510

  Fly  1131 DEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYG--DTSRQVPMQQIIEAAKM 1193
            |.|.:.:|...| .|::...||..:|.|||||.||..|||:||.||  |.| ||.::.|..||::
Zfish   511 DSGIVSVDGHDI-RDLNPYWLRSHIGTVSQEPVLFSCSIAENIAYGAPDPS-QVTVEDIYRAAQI 573

  Fly  1194 ANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQ 1258
            ||||:||...|..||||:|.||..||||||||:|||||:::|||||||||||||||.::|.:||:
Zfish   574 ANAHDFIQEFPKGYDTVVGEKGVLLSGGQKQRVAIARALLKNPKILLLDEATSALDAENEFLVQE 638

  Fly  1259 ALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKN-GIYSKLYRCQ 1316
            ||:....|||.::|||||||||:|:.:.|:...:::|.||||||||.: |::.||...|
Zfish   639 ALERLMDGRTVLIIAHRLSTIQSADSVAVLDQHRVMEIGSHSQLLANDQGLFRKLMEKQ 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	217/637 (34%)
		ABC_membrane	<147..333	CDD:279056
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216
		ABC_membrane	749..1019	CDD:279056	64/281 (23%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	126/242 (52%)
abcb10	XP_001343218.3	MsbA_rel	123..697	CDD:131259	211/609 (35%)
		ABC_membrane	141..402	CDD:279056	66/284 (23%)
		P-loop_NTPase	457..697	CDD:304359	126/241 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910