DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10226 and abcc6b.2

DIOPT Version :9

Sequence 1:	NP_648040.1	Gene:	CG10226 / 38725	FlyBaseID:	FBgn0035695	Length:	1320	Species:	Drosophila melanogaster
Sequence 2:	XP_003198194.2	Gene:	abcc6b.2 / 100002917	ZFINID:	ZDB-GENE-110208-2	Length:	1502	Species:	Danio rerio

Alignment Length:	1333	Identity:	292/1333 - (21%)
Similarity:	537/1333 - (40%)	Gaps:	299/1333 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 KDSVSFGILMTLNTLL--------MLFSGVYYVDAFNRLALK--------------LTVRMRREF 162
            :|::.|.|...|:.||        .|:.|  |:.||:...|.              |||.||
Zfish   326 QDALMFSIPQVLSLLLGYVRDEDAPLWKG--YLFAFSLFLLSCLQSLFNHQYMYTCLTVGMR--- 385

  Fly   163 FKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEI--------MCDVIISVVLSF 219
            .|..:...:  :..:...|.|.|.|..:.:|.:.::.:....|:.        :..:.|::.|.|
Zfish   386 VKTAVMGLV--YRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFF 448

  Fly   220 IYGWK----LALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGG 280
            :  |:    ..||.:..:.|...:|..:|..:.||...:.........::.|::..|:.:..:..
Zfish   449 L--WQHLGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAW 511

  Fly   281 E---RSESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILY-----YRD 337
            |   |...|.|......|||..:               :|:.....||.....||.:     |
Zfish   512 EKAFRERVLGYREKELNALKKSQ---------------ILYSVSIASFNSSTLLIAFAMFGVY-- 559

  Fly   338 PSIPIDEREYTPA---------------------VVMIVISGIIVSANQISRTSPFLETFAMARG 381
              :.||::....|                     :.|.....::||   :.|...||:...:.
Zfish   560 --VLIDDKHVLDAQKIFVSMALINILKAPLSQLPIAMSTTMQVVVS---LKRLGTFLDQDELK-- 617

  Fly   382 SASAILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVA 446
                 ||.:.|......:...  ::|.|.          |.: :::....||.:||.|:.|..||
Zfish   618 -----LDSVQRVPYNPNIESV--VINNGT----------FSW-SKDSTPCLRRINVKVQRGSLVA 664

  Fly   447 LVGPSGCGKSTCIQLLQRFYDPVFGQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIR 511
            :||..|.|||:.:..:....:...|.:.:.|             ::..|.|:..:...::.:||.
Zfish   665 VVGHVGSGKSSLLSAMLGEMEKKSGHITITG-------------SVGYVPQQAWIQNATLKDNIL 716

  Fly   512 HG---KPEATQKEVEDAA-----KAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALI 568
            .|   |....||.:|..|     :...|.|         .|:|.|||:.|||||:||:::|||:.
Zfish   717 FGCEKKDSLYQKVLEACALLPDLEILPARD---------ATEIGEKGLNLSGGQKQRVSLARAVY 772

  Fly   569 QQPKILLLDEATSALDYH-----SEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKA 628
            :...|.|||:..||:|.|     .||::  ..:.:.|.:|.::|:|.||.:..|..|:.:.:|:.
Zfish   773 RNSDIYLLDDPLSAVDAHVGQHIFEKVI--GPNGSLKNKTRVLVTHGLSFLPQADLILVMADGEI 835

  Fly   629 VEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSI--V 691
            .|.|::.||:                 |.:....||:..: :.|||.|..::    |||.|:  :
Zfish   836 KEMGSYAELL-----------------SRKNAFAELKAFS-VSERKESATLK----GTRKSVSFL 878

  Fly   692 SLEKNAEFQMKNLNGLANITMNQEIDDP----------RVPSANFIST----------FFRILGW 736
            |::..:...::...|.|:|...:.|.||          |:..|:...|          :||.:|.
Zfish   879 SIKDFSTDLIRGDLGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRTIGL 943

  Fly   737 ARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKP------TDEEVLEQSASMAIISL--- 792
            |     |:|             |:..:...:...|||..      .|:.|:..:.....:.|
Zfish   944 A-----FII-------------PIIFLYAFQQVASLAYNYWLSLWADDPVINGTQVNTDLKLGVY 990

  Fly   793 -VIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAAS 856
             .:|.|.|:..:..|...:|.|:..:.::.......:::..|.:|:
Zfish   991 GALGFAQGIAIFGTTVAISLGGIIASRQLHLDLLNNVLHSPMSFFE------------------- 1036

  Fly   857 VQGAIGFPLSNIIQAFTNFICSIAIAFPYS-----------WELALICLSTSPFMVASIV----- 905
                 ..|..|::..|:..|.:|....|:.           .|:.:|.|..:||....|:
Zfish  1037 -----STPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYVFKLLEVCIIVLMATPFAGVIILPLTLL 1096

  Fly   906 --FEARFGEKSALKEKEVLEETSR--IAT---ETITQIRTVAGLRREEELIKIYDKEVERYRHQI 963
              |...|...::.:.:. ||..||  |.|   ||:.....:.....:...|...:..|:..:...
Zfish  1097 YAFIQSFYVATSCQLRR-LESVSRSPIYTHFNETVQGASVIRAFGEQPRFILQANCRVDLNQTSY 1160

  Fly   964 LSRL---KWRGL-VNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSL 1024
            ..|.   :|..: :..|| :|:....|:....|....:.|.:.......:..|.:....:    .
Zfish  1161 FPRFVASRWLAVNLEFLG-NLLVLAAAILSVMGRATLSPGTVGLAVSHSLQVTGILSWIV----R 1220

  Fly  1025 AFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQ--GVSYR-GLNFSYP 1086
            ::|...| .::|..|:.|..:...  ::|.:||.....:......::..|  |:.|| ||:::
Zfish  1221 SWTDVEN-NIVSVERVKEYAETAK--EAPWTFEDSPLPSDWPRSGSIGFQAYGLQYRKGLDWA-- 1280

  Fly  1087 SRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDPDEGKILIDQESIHHDMDLKTL 1151
                   |:..:|.:|:.:.|.:||.:|:|||:....:.|..:..:|||.||..:| .::.|..|
Zfish  1281 -------LKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINI-AEIGLHEL 1337

  Fly  1152 RRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGT 1216
            |.|:.|:.|:|.||..|:..|:   |...:...:::..:.::|:...|:..||.:.:......|.
Zfish  1338 RSRITIIPQDPVLFSGSLRINL---DPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECSEGGE 1399

  Fly  1217 QLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQN 1281
            .||.||:|.|.:|||::|..|||:|||||:|:|.:::.::|..:.:.....|.:.|||||:||.:
Zfish  1400 NLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMD 1464

  Fly  1282 ANVICVIQAGKIVEQGSHSQLLAKNGIYSKLYR 1314
            ...:.|:..|.|.|..|.|.|::::|.:.::.|
Zfish  1465 YTRVIVMDRGNITEIDSPSNLISQHGQFYRMCR 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10226	NP_648040.1	PTZ00265	81..1311	CDD:240339	291/1328 (22%)
		ABC_membrane	<147..333	CDD:279056	38/214 (18%)
		ABC_MTABC3_MDL1_MDL2	414..649	CDD:213216	67/247 (27%)
		ABC_membrane	749..1019	CDD:279056	48/306 (16%)
		ABC_MTABC3_MDL1_MDL2	1076..1316	CDD:213216	76/240 (32%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	292/1333 (22%)
		ABC_membrane	320..587	CDD:294371	53/288 (18%)
		ABCC_MRP_domain1	633..834	CDD:213217	64/237 (27%)
		ABC_membrane	950..1215	CDD:279056	47/290 (16%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	73/232 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000