Protein Alignment LanA and NTN1

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: NP_004813.2
• Gene: NTN1 / 9423
• HGNCID: 8029
• Length: 604
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 146/488 - (29%)
• Similarity: 226/488 - (46%)
• Gaps: 79/488 - (16%)

  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |.:.|.|.|:.:..::|||:.   |..||.:.....|         :.:.|..|:.:.|::.|||
Human    53 PDFVNAAFGKDVRVSSTCGRP---PARYCVVSERGEE---------RLRSCHLCNASDPKKAHPP 105

  Fly    91 ENAIDGTE----AWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLEKSTD 150
            ....|...    ..|||   ...::| :.|.||::..::|.|.|:.::. .||||....:.||.|
Human   106 AFLTDLNNPHNLTCWQS---ENYLQFPHNVTLTLSLGKKFEVTYVSLQF-CSPRPESMAIYKSMD 166

  Fly   151 YGKTWTPWQHFSDTPADCETYFGKDTYKPITR--DDDVICTTEYSKIVPLENGEIPVMLLNERPS 213
            ||:||.|:|.:|   ..|...:.:....|||:  :.:.:||..::.:.||..|.|....|:.|||
Human   167 YGRTWVPFQFYS---TQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPS 228

  Fly   214 STNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRR--YFYSIKDISIGGRCMCN 276
            :.::.||.|||:|..||::|:...|.     |......:|.:...|  |||::.|:.:||||.||
Human   229 AHDFDNSPVLQDWVTATDIRVAFSRL-----HTFGDENEDDSELARDSYFYAVSDLQVGGRCKCN 288

  Fly   277 GHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGHSNE 341
            |||..| |:|....   |.|.|:|:|.|.:|:.|.|....:.|::.|......|..|||:.|:..
Human   289 GHAARC-VRDRDDS---LVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARR 349

  Fly   342 CKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCD 406
            |:::.|:.:      :.|. ..||||.||:|||.|.:|:.||..|||..||.......|..|.|.
Human   350 CRFNMELYK------LSGR-KSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCH 407

  Fly   407 YFFSTGH-CEEETGNCECRAAFQPPSCDSCAYGYY----------------------GYPNCREC 448
            ...:.|. |.:.||.|.|:......:|:.||.||.                      ......:|
Human   408 PVGAAGKTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAASSVEEPEDC 472

  Fly   449 ECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQ 481
            :.        :|:|..|:   .|||.. .|||:
Human   473 DS--------YCKASKGK---LKINMK-KYCKK 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	73/253 (29%)
		EGF_Lam	272..>314	CDD:238012	19/41 (46%)
		EGF_Lam	332..389	CDD:238012	22/56 (39%)
		EGF_Lam	402..443	CDD:238012	13/63 (21%)
		Laminin_EGF	448..497	CDD:395007	10/34 (29%)
		Laminin_EGF	495..543	CDD:395007
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:395007
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534
		SMC_prok_B	2356..>2705	CDD:274008
		Laminin_II	2566..2700	CDD:368703
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
NTN1	NP_004813.2	LamNT	46..283	CDD:214532	73/253 (29%)
		EGF_Lam	284..329	CDD:238012	20/48 (42%)
		Laminin_EGF	341..401	CDD:395007	25/66 (38%)
		Laminin_EGF	404..>441	CDD:395007	11/36 (31%)
		NTR_netrin-1_like	487..601	CDD:239634	3/8 (38%)
		Cell attachment site. /evidence=ECO:0000255	530..532