Protein Alignment LanA and SLK19

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: NP_014838.3
• Gene: SLK19 / 854370
• SGDID: S000005721
• Length: 821
• Species: Saccharomyces cerevisiae
• Alignment Length: 607
• Identity: 126/607 - (20%)
• Similarity: 228/607 - (37%)
• Gaps: 175/607 - (28%)

  Fly  2121 DVTDRMRYQIDSVLEDFNSVTLAF-FTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSK--KANS 2182
            ::||:: |.::.:|....|...:. |..:|||...||.              :||:..|  |.|:
Yeast   315 ELTDQI-YHLNQMLNSLISKNESLSFQYEKLNKNHQLL--------------IDLTNEKLDKLNT 364

  Fly  2183 ELESDAKSYAKQVNQTLANAFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAA 2247
            |.|||                              :|..|..|.  :.||....::.|:.| :..
Yeast   365 ERESD------------------------------IAKVEKFKK--RIKELNTEIKVLNSN-QKI 396

  Fly  2248 ASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQN-------KSLN 2305
            ...|.||::.:..||.|:...|...|..||::|....   .|:..:...:|..|       .:||
Yeast   397 LQEKFDASITEVNHIKGEHENTVNTLQQNEKILNDKN---VELENMKAELKGNNDKLSEYETTLN 458

  Fly  2306 ALKNDIGEFSDHLEDLFNWSEASQAKSADVERRNVANQKAFDNSKFDTVSEQKLQAEKNIKDAG- 2369
            .|.:.|.:.:|.:|            |.|:..::..|:  .||.|...  ::.|...|:..|:.
Yeast   459 DLNSRIVQLNDKIE------------STDIVLKSKENE--LDNLKLSL--KETLSISKDFNDSDL 507

  Fly  2370 ----NFLINGDLTLNQINQKLDNLRDALNELNSFN-KNVDEELPVREDQHK----EADALTDQAE 2425
                |.||:   |.|.:.||:|:    ||.||..| |.|.::|...|:..|    |.|:|..:.:
Yeast   508 IGQINELIS---TKNNLQQKMDD----LNNLNDDNLKVVQDKLIKNEETLKLKEAEIDSLNSEMD 565

  Fly  2426 QKAAELAIKAQDL---AAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKT 2487
            :...::..|..:.   .::|..:...|:......|..:|.:|.::.::...::.|:...|...|
Yeast   566 ELKKQITSKDDEFKMWQSKYETVEDEAKIRNAEVTELNGDIEDLKESKLHLEETITELENKVHK- 629

  Fly  2488 DGIEERAHLADTGSTDLLQRARQSLQKVQDDLEP-RLNASAGKVQKISAVNN------ATEHQLK 2545
              :|....|           .:|..:|...:||. :|..|..:.:.|..:.|      :.:::||
Yeast   630 --LENECEL-----------EKQKFEKTSLELESLQLKNSNIQAEHIKELENLHENLISLQNELK 681

  Fly  2546 DINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEPVSVQTPKELEKAHGINRDLDLTNK 2610
            ..:..|..|..|::..|.:|:|.|.|..|.                          |...|..::
Yeast   682 ISSDRITTLTKENEVLMEQNNNNNNSVTLS--------------------------NDQKDRDDE 720

  Fly  2611 DVSQANKQLDD--------VEGSVSKLSELAEDI-------EEQQ----------------HRVG 2644
            .:....||:.|        .:.:..:|..||||:       .||:                .::.
Yeast   721 KIKSLGKQVQDWKEKYEAKEKDTNKRLKLLAEDLYIQYSSKHEQKVKLLKKGYENKYQNKFDQLN 785

  Fly  2645 SQSRQLGQEIENLKAQVEAARQ 2666
            .:::.|.:|||.|..|:.:.|:
Yeast   786 LENKTLSEEIEQLNKQLSSERE 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		Laminin_EGF	448..497	CDD:395007
		Laminin_EGF	495..543	CDD:395007
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:395007
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534	58/265 (22%)
		SMC_prok_B	2356..>2705	CDD:274008	73/362 (20%)
		Laminin_II	2566..2700	CDD:368703	23/132 (17%)
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
SLK19	NP_014838.3	PTZ00482	25..>185	CDD:240433
		SMC_N	<356..699	CDD:481474	88/415 (21%)
		Fungal_TACC	742..818	CDD:403801	14/66 (21%)