DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and Ntng1

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	XP_006502418.1	Gene:	Ntng1 / 80883	MGIID:	1934028	Length:	581	Species:	Mus musculus

Alignment Length:	583	Identity:	149/583 - (25%)
Similarity:	222/583 - (38%)	Gaps:	174/583 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVG---ANTEHDHIDYSVIQGQVCDYCD 80
            |.:.:|.||            ..|||   |.||.:|.:..   .|.|                ||
Mouse    60 YLKVKLDPP------------DITCG---DPPESFCAMGNPYMCNNE----------------CD 93

  Fly    81 PTVPERNHPPENAID----GTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPG 141
            .:.||..||||...|    ....:|||.......|..:||:|:::.:...:....:....|.||.
Mouse    94 ASTPELAHPPELMFDFEGRHPSTFWQSATWKEYPKPLQVNITLSWSKTIELTDNIVITFESGRPD 158

  Fly   142 LWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKD--TYKPITRDD--DVICTTEY-------SKI 195
            ...||||.|||:||.|:|:::   .||...|..|  :.|.:::..  ::|||.||       |||
Mouse   159 QMILEKSLDYGRTWQPYQYYA---TDCLHAFHMDPKSVKDLSQHTVLEIICTEEYSTGYSTNSKI 220

  Fly   196 VPLENGEIPVMLLNER------PSSTNYFN-------STVLQEWTRATNVRIRLLRTKNLLGHLM 247
            :..|        :.:|      |...|..:       :..|:::...|::||||||.  .:|.:.
Mouse   221 IHFE--------IKDRFAFFAGPRLRNMASLYGQLDTTKKLRDFFTVTDLRIRLLRP--AVGEIF 275

  Fly   248 SVARQDPTVTRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCP 312
                .|.....||||:|.||.:.|||.||.||.:|...:.|     |.|.|:|:|.|..|.:|..
Mouse   276 ----VDELHLARYFYAISDIKVRGRCKCNLHATSCLYDNSK-----LTCECEHNTTGPDCGKCKK 331

  Fly   313 GFEQKKWRQNTN------------------------------------ARPFNCEP--------- 332
            .::.:.|...:.                                    :.|....|
Mouse   332 NYQGRPWSPGSYLPIPKGTANTCIPSISSIGTPPKFNRIWPNISSLEVSNPKQVAPKLALSTVSS 396

  Fly   333 ---------CNCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYR 388
                     |.|.||||.|.|.:.:|..              :|.:|:|||.|.:|..|:..|:|
Mouse   397 VQVANHKRDCECFGHSNRCSYIDLLNTV--------------ICVSCKHNTRGQHCELCRLGYFR 447

  Fly   389 PKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYG---YYGYPNCRECEC 450
            ......::.:||..|.|:...|.......:|.|||:.....|.||.|..|   |||      |:.
Mouse   448 NASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCDECLPGNSWYYG------CQP 506

  Fly   451 NLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGE 513
            |:......||  ::|..|...:..|      |.:.|.|. .|:...|.:.||    |...:|:
Mouse   507 NVCDNELLHC--QNGGTCQNNVRCA------CPDAYTGI-LCEKLRCEEAGS----CGSESGQ 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	77/282 (27%)
		EGF_Lam	272..>314	CDD:238012	16/41 (39%)
		EGF_Lam	332..389	CDD:238012	19/74 (26%)
		EGF_Lam	402..443	CDD:238012	15/43 (35%)
		EGF_Lam	448..491	CDD:238012	10/42 (24%)
		Laminin_EGF	495..543	CDD:278482	5/19 (26%)
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
Ntng1	XP_006502418.1	Laminin_N	71..295	CDD:365840	73/259 (28%)
		EGF_Lam	296..342	CDD:238012	17/50 (34%)
		EGF_Lam	406..454	CDD:238012	19/61 (31%)
		EGF_Lam	462..509	CDD:214543	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1836
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810