DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and ntn5

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	XP_001920036.4	Gene:	ntn5 / 796299	ZFINID:	ZDB-GENE-130530-593	Length:	839	Species:	Danio rerio

Alignment Length:	538	Identity:	127/538 - (23%)
Similarity:	190/538 - (35%)	Gaps:	183/538 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 HPPENAIDGTEAWWQSPPLSRGMKFNEVNLTINFEQEFHVAYL---FIRMGNSPRPGLWTLEKST 149
            |.|.|.     ..|.:   |.|....:..|.:...:.|.:.|:   |.:..:|......|:.||.
Zfish    89 HNPHNL-----TCWTA---SEGSSGGDWTLMVPLGRRFEITYISLQFCQQVDSVESYSITILKSM 145

  Fly   150 DYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKIVPLENGEIPVM-------- 206
            |:|::|.|.|.:|:   ||...||        |....|..|::.:..||.:...|:.
Zfish   146 DFGQSWRPLQFYSN---DCMGSFG--------RPAQSIALTKHQETEPLCSDPRPLQKHRGNIVL 199

  Fly   207 ---LLNERPSSTNYFNSTVLQEWTRATNVRI------------------------------RLLR 238
               .|:.||||.::..|..||:|..||:::|                              :.||
Zfish   200 AFSTLDGRPSSPDFDYSPGLQDWVTATDIKIVFHQSMDKMKKQEEKMNEVGGAYRWRERGDKALR 264

  Fly   239 ----------------------------------------TKNLLGHLMSVAR----------QD 253
                                                    |:..:|....|.|          ||
Zfish   265 FGEKNTGTKATDVWGNSREKQTSTQRFKNKSTVLQSGHNVTRKEMGSQGRVGRGHRKDNSRPCQD 329

  Fly   254 PTVTR-------------------------RYF----------------------YSIKDISIGG 271
            .|..|                         .:|                      .::.|:.:||
Zfish   330 GTCDRSLNIQQQSSKGRELRRRRNNGGRGKSHFKQRKNGSRQLVPSSLYAPTKPTLALSDLQVGG 394

  Fly   272 RCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCH 336
            ||.|||||..|...:....|    |:|:|||.|..|:.|...|..:.|::.|.::|..|.||.|:
Zfish   395 RCKCNGHASRCRRDNQGHAV----CQCEHHTSGPDCDMCEQFFYDRPWQRATPSQPHPCVPCECN 455

  Fly   337 GHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCS 401
            ||||:|::...|.::...:       .||||..|:|:|.|.:|..|:..|.|...|..|....|.
Zfish   456 GHSNKCRFSMAVYQQSGRV-------SGGVCLKCRHHTTGRHCQFCQNGYMRDHSKALNHRKACQ 513

  Fly   402 PCQCDYFFSTGH-CEEETGNCECRAAFQPPSCDSCAYGY-YGYPNCREC---ECNLNGTNGYHCE 461
            ||||....:.|. |.:.||.|.||.......|:.||.|| .|:...|.|   :.....|..|..:
Zfish   514 PCQCHPVGAVGRWCNQSTGQCLCREGVIGQRCNRCAPGYKQGHSPLRPCIRIQEVAPPTPVYQPQ 578

  Fly   462 AESGQQCPCKINFAGAYC 479
            ...|::|.       :||
Zfish   579 YSIGEECV-------SYC 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	54/323 (17%)
		EGF_Lam	272..>314	CDD:238012	17/41 (41%)
		EGF_Lam	332..389	CDD:238012	20/56 (36%)
		EGF_Lam	402..443	CDD:238012	17/42 (40%)
		EGF_Lam	448..491	CDD:238012	7/35 (20%)
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntn5	XP_001920036.4	Laminin_N	51..233	CDD:322101	42/162 (26%)
		EGF_Lam	395..440	CDD:238012	19/48 (40%)
		EGF_Lam	451..509	CDD:238012	23/64 (36%)
		Laminin_EGF	515..557	CDD:278482	16/41 (39%)
		NTR_netrin-1_like	603..718	CDD:239634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910