DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and si:dkey-220k22.1

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	XP_001336203.3	Gene:	si:dkey-220k22.1 / 795920	ZFINID:	ZDB-GENE-060526-255	Length:	574	Species:	Danio rerio

Alignment Length:	532	Identity:	123/532 - (23%)
Similarity:	192/532 - (36%)	Gaps:	179/532 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 CECNKIGSI-TNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPT--CSYCDCDNQGTESEICNKQ 556
            |.|:..||: ...|:..|.:|.|:..:.|..|:.|:..||...|  |..|||.:.|..|.:|| .
Zfish   177 CNCSTEGSVDPYTCDSVTSQCVCIIGYTGQRCDECEDEYFTNGTNGCQPCDCHSYGAVSGLCN-S 240

  Fly   557 SGQCICREGFGGPRCDQCLPGFYNYPD--CKPCNCSSTGSSAITCDNTGKC-NCLNNFAGKQCTL 618
            ||.|.|:.|..|.:||.|||||.|:..  |:.|.|::  .|:.....:|.| ||..|..|:.|..
Zfish   241 SGMCNCKMGVHGDKCDDCLPGFMNFSSTGCQTCQCNN--HSSYCHPQSGICMNCQGNTEGRSCEK 303

  Fly   619 CTAGYYSYP------DCLPCHCDSHGSQGVSCNSD--GQ--CL-CQPNFDGRQCDSCKEGFYNFP 672
            |...:|..|      .|:||.|.|..|.| ||..|  ||  |: |:|.:.|..|:.|.:||||..
Zfish   304 CKYNFYRRPGSPVTEPCIPCPCSSVTSTG-SCKLDSRGQPYCVQCKPEYQGPNCEQCSDGFYNAD 367

  Fly   673 S-CEDCNCDPAGVIDKFAGCGSVPVGELCKCKERVTGRICNECKPLYWNLNISNTEGCEICDCWT 736
            | |..|||...|                   ..|::.|||:.
Zfish   368 SICLPCNCSGNG-------------------DPRLSPRICHP----------------------- 390

  Fly   737 DGTISALDTCTSKSGQC-PCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVCDKI 800
                   ||     |.| .|..::.|..|:.|.||
Zfish   391 -------DT-----GYCLSCINNSTGPHCERCADG------------------------------ 413

  Fly   801 SGQCKCHPRITGLACTQPLTTHFFPT-LHQFQYEYEDGSLPSGTQVRYDYDEAAFPGFSSKGYVV 864
                     .||    .||..:..|| :|         :.||                |:.|:.:
Zfish   414 ---------FTG----DPLARNCTPTVVH---------TTPS----------------STTGWFL 440

  Fly   865 FNAIQNDVRNEVNVFKSSLYRIVLRYVNPNAENVTATISVTSDNPLEVDQHVKVLLQPTSEPQFV 929
            :..:.:..........::.....|....||....|.|::     ||           |.::...:
Zfish   441 YTTMTSSPNATTQFTSTTALLSSLASSTPNTTTTTTTVT-----PL-----------PWNQFNII 489

  Fly   930 TVAGPLGVKPSAIVLDPGRYVFTTKANKNVMLDYFV-------LLPAAYYE-------AGILTRH 980
            .:|..:.|..:.:.:..|.|.:....|:.:...::.       :..::|::       :|:|...
Zfish   490 ILAVIIIVVIALLAVVGGVYTYREYQNRKLNAPFWTIELKEDNISFSSYHDSIPNADISGLLEDE 554

  Fly   981 ISNPCELGNMEL 992
            :|   ::||.:|
Zfish   555 VS---DMGNGQL 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		EGF_Lam	448..491	CDD:238012
		Laminin_EGF	495..543	CDD:278482	16/50 (32%)
		Laminin_EGF	541..589	CDD:278482	23/49 (47%)
		Laminin_EGF	587..634	CDD:278482	16/53 (30%)
		EGF_Lam	631..673	CDD:238012	21/46 (46%)
		Laminin_EGF	677..729	CDD:278482	8/51 (16%)
		Laminin_EGF	732..782	CDD:278482	10/50 (20%)
		EGF_Lam	785..828	CDD:238012	6/43 (14%)
		CBM6-CBM35-CBM36_like	831..966	CDD:271143	17/141 (12%)
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
si:dkey-220k22.1	XP_001336203.3	EGF_Lam	177..223	CDD:214543	14/45 (31%)
		Laminin_EGF	226..273	CDD:278482	22/47 (47%)
		EGF_Lam	273..315	CDD:238012	13/43 (30%)
		EGF_Lam	322..373	CDD:238012	23/51 (45%)
		EGF_Lam	372..422	CDD:238012	22/146 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910