Protein Alignment LanA and ntn5

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: NP_001072385.1
• Gene: ntn5 / 779839
• XenbaseID: XB-GENE-22063027
• Length: 601
• Species: Xenopus tropicalis
• Alignment Length: 495
• Identity: 150/495 - (30%)
• Similarity: 225/495 - (45%)
• Gaps: 87/495 - (17%)

  Fly    19 YCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTV 83
            ||    .|.:.|:|.|:::..:.|||:.   |:..|..         :|.:.:..:.|..||...
 Frog    51 YC----IPDFINVALGQEVITSNTCGRT---PQKLCYF---------LDSTNVTSRRCQLCDQKR 99

  Fly    84 PERNHPPENAID-GTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLE 146
            ||.::||....| ..:..|:|   ..|:.| ..|.||:...:.|.:.|..:|. .||||....:.
 Frog   100 PENSYPPSYMTDTDAQTCWKS---ESGITFPQNVTLTLPLGRRFELVYASLRF-CSPRPDSMAIY 160

  Fly   147 KSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITR--DDDVICTTEYSKIVPLENGEIPVMLLN 209
            ||.||||||.|:|.:|   ..|...:.:.|...|::  ..:..||...:.:.||..|.:..|.|.
 Frog   161 KSMDYGKTWIPFQFYS---THCRRVYDQATTSAISKPMQHEATCTDFQTGVKPLTKGLVAFMPLA 222

  Fly   210 ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCM 274
            .|||:..:..|.|||:|..||::|:...|..:  |..|.:.|      :..||.:.:|.:||||.
 Frog   223 GRPSARRFEYSPVLQDWVTATDIRVVFNRLHH--GKKMGIRR------KTAFYGVSEIQVGGRCK 279

  Fly   275 CNGHADTCDV-KDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGH 338
            |||||..|.. |:.      |.|.|||:|.|.:|:.|.|.:..:.|::.|.:....|..|.|:.|
 Frog   280 CNGHASRCTAGKEG------LMCECQHNTIGPECDACKPFYYDRPWQRATPSNAHECVACECNLH 338

  Fly   339 SNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPC 403
            |:.|:::.|:.:      :.|. ..||||.||:|||.|.:|:.||..|.|...|.......|.||
 Frog   339 SHRCRFNMELYK------LSGR-KSGGVCLNCRHNTAGRHCHYCKQGYKRDLSKPITSRKACKPC 396

  Fly   404 QCDYFFS-TGHCEEETGNCECRAAFQPPSCDSCAYGYY--------------------GYPNCRE 447
            ||....: ...|.:.||.|:|:.....|:|:.||.||.                    .||  :|
 Frog   397 QCHPIGAVNAMCNQTTGQCQCKTGVTGPTCNRCAPGYQQSRSAHMPCVRIQEEMTTTASYP--QE 459

  Fly   448 CECNLNGTNGYHCEAESGQQCPCKINFAGA------YCKQ 481
            .:.   ||||..|      |..||.:.:..      |||:
 Frog   460 WKA---GTNGTEC------QSYCKPSHSRVHMNLRKYCKK 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	73/255 (29%)
		EGF_Lam	272..>314	CDD:238012	19/42 (45%)
		EGF_Lam	332..389	CDD:238012	21/56 (38%)
		EGF_Lam	402..443	CDD:238012	15/61 (25%)
		Laminin_EGF	448..497	CDD:395007	11/40 (28%)
		Laminin_EGF	495..543	CDD:395007
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:395007
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534
		SMC_prok_B	2356..>2705	CDD:274008
		Laminin_II	2566..2700	CDD:368703
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntn5	NP_001072385.1	Laminin_N	48..276	CDD:470680	73/255 (29%)
		EGF_Lam	277..321	CDD:238012	20/49 (41%)
		Laminin_EGF	333..393	CDD:395007	23/66 (35%)
		EGF_Lam	395..444	CDD:238012	15/48 (31%)
		NTR_netrin-1_like	484..598	CDD:239634	3/7 (43%)