DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and ntn1

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_001072385.1	Gene:	ntn1 / 779839	XenbaseID:	XB-GENE-989335	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	495	Identity:	150/495 - (30%)
Similarity:	225/495 - (45%)	Gaps:	87/495 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTV 83
            ||    .|.:.|:|.|:::..:.|||:.   |:..|..         :|.:.:..:.|..||...
Frog    51 YC----IPDFINVALGQEVITSNTCGRT---PQKLCYF---------LDSTNVTSRRCQLCDQKR 99

  Fly    84 PERNHPPENAID-GTEAWWQSPPLSRGMKF-NEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLE 146
            ||.::||....| ..:..|:|   ..|:.| ..|.||:...:.|.:.|..:|. .||||....:.
Frog   100 PENSYPPSYMTDTDAQTCWKS---ESGITFPQNVTLTLPLGRRFELVYASLRF-CSPRPDSMAIY 160

  Fly   147 KSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITR--DDDVICTTEYSKIVPLENGEIPVMLLN 209
            ||.||||||.|:|.:|   ..|...:.:.|...|::  ..:..||...:.:.||..|.:..|.|.
Frog   161 KSMDYGKTWIPFQFYS---THCRRVYDQATTSAISKPMQHEATCTDFQTGVKPLTKGLVAFMPLA 222

  Fly   210 ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTVTRRYFYSIKDISIGGRCM 274
            .|||:..:..|.|||:|..||::|:...|..:  |..|.:.|      :..||.:.:|.:||||.
Frog   223 GRPSARRFEYSPVLQDWVTATDIRVVFNRLHH--GKKMGIRR------KTAFYGVSEIQVGGRCK 279

  Fly   275 CNGHADTCDV-KDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPCNCHGH 338
            |||||..|.. |:.      |.|.|||:|.|.:|:.|.|.:..:.|::.|.:....|..|.|:.|
Frog   280 CNGHASRCTAGKEG------LMCECQHNTIGPECDACKPFYYDRPWQRATPSNAHECVACECNLH 338

  Fly   339 SNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPC 403
            |:.|:::.|:.:      :.|. ..||||.||:|||.|.:|:.||..|.|...|.......|.||
Frog   339 SHRCRFNMELYK------LSGR-KSGGVCLNCRHNTAGRHCHYCKQGYKRDLSKPITSRKACKPC 396

  Fly   404 QCDYFFS-TGHCEEETGNCECRAAFQPPSCDSCAYGYY--------------------GYPNCRE 447
            ||....: ...|.:.||.|:|:.....|:|:.||.||.                    .||  :|
Frog   397 QCHPIGAVNAMCNQTTGQCQCKTGVTGPTCNRCAPGYQQSRSAHMPCVRIQEEMTTTASYP--QE 459

  Fly   448 CECNLNGTNGYHCEAESGQQCPCKINFAGA------YCKQ 481
            .:.   ||||..|      |..||.:.:..      |||:
Frog   460 WKA---GTNGTEC------QSYCKPSHSRVHMNLRKYCKK 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	73/255 (29%)
		EGF_Lam	272..>314	CDD:238012	19/42 (45%)
		EGF_Lam	332..389	CDD:238012	21/56 (38%)
		EGF_Lam	402..443	CDD:238012	15/61 (25%)
		EGF_Lam	448..491	CDD:238012	11/40 (28%)
		Laminin_EGF	495..543	CDD:278482
		Laminin_EGF	541..589	CDD:278482
		Laminin_EGF	587..634	CDD:278482
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntn1	NP_001072385.1	Laminin_N	61..276	CDD:365840	68/241 (28%)
		EGF_Lam	277..321	CDD:238012	20/49 (41%)
		EGF_CA	333..386	CDD:389777	22/59 (37%)
		EGF_Lam	395..444	CDD:238012	15/48 (31%)
		NTR_netrin-1_like	484..598	CDD:239634	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910