DRSC/TRiP Functional Genomics Resources

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Protein Alignment LanA and USH2A

DIOPT Version :9

Sequence 1:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster
Sequence 2:NP_996816.3 Gene:USH2A / 7399 HGNCID:12601 Length:5202 Species:Homo sapiens


Alignment Length:1596 Identity:397/1596 - (24%)
Similarity:625/1596 - (39%) Gaps:363/1596 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 GALLVILAISYCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQG 73
            |.||.:.|.|:|:...:.|        :::..|         :.||                |..
Human   291 GDLLRLHAQSHCRCPGSHP--------RVHPLA---------QRYC----------------IPN 322

  Fly    74 QVCDYCDPTVPERN---HPPENAID---GTEAWWQSPPLSRGMKFNE-VNLTINFEQ-EFHVAYL 130
            ...|..|..|...|   ||.....|   ||.  |.|...:...:.|: |.::::.|. ::.|.|:
Human   323 DAGDTADNRVSRLNPEAHPLSFVNDNDVGTS--WVSNVFTNITQLNQGVTISVDLENGQYQVFYI 385

  Fly   131 FIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDVICTTEYSKI 195
            .|:. .||:|....:::..:....|..||:|:   .:|.. ||......:.:.|.|.| .:.|..
Human   386 IIQF-FSPQPTEIRIQRKKENSLDWEDWQYFA---RNCGA-FGMKNNGDLEKPDSVNC-LQLSNF 444

  Fly   196 VPLENGEIPVMLL----NERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDPTV 256
            .|...|.:...:|    |.||...|::|:..|||:.:||.:|...        |......:....
Human   445 TPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHF--------HGQYYTTETAVN 501

  Fly   257 TRRYFYSIKDISIGGRCMCNGHADTCDVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQ 321
            .|..:|::.:|:|.|||.|:||||.||.  ...|.|.| |..:..|.|:.|:.|.|.:..|.:||
Human   502 LRHRYYAVDEITISGRCQCHGHADNCDT--TSQPYRCL-CSQESFTEGLHCDRCLPLYNDKPFRQ 563

  Fly   322 NTNARPFNCEPCNCHGHSNECKYDEEVNRKGLSLD--IHGHY-DGGGVCQNCQHNTVGINCNKCK 383
            ......|||:||.|:.||..|.|:       :|:|  ...|: .|||||.:|:|||.|.||..||
Human   564 GDQVYAFNCKPCQCNSHSKSCHYN-------ISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCK 621

  Fly   384 PKYYRPKGKHWNETDVCSPCQCDYFFSTGH------CEEETGNCECRAAFQPPSCDSCAYGYYGY 442
            ..::|..|...:..|||.||.||   :.|.      |::..|.|.|:.......|:.|..|:|..
Human   622 DYFFRQVGADPSAIDVCKPCDCD---TVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNL 683

  Fly   443 -----PNCRECECNLNGT--NGYHCEAESGQQCPCKINFAGAYCKQCAEGY-----YGFPECKAC 495
                 ..|..|.||.:||  ....|...|| ||.||.|..|..|..|..|:     :....|:.|
Human   684 QELDPDGCSPCNCNTSGTVDGDITCHQNSG-QCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPC 747

  Fly   496 ECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYF--NYPTCSYCDCDNQGT-ESEICNKQS 557
            :||..||:...||..:|:|:|.....|..|:.|:..::  :...|..||||..|: ...:||.::
Human   748 QCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKT 812

  Fly   558 GQCICREGFGGPRCDQCLPG-FY----NYPDCKPCNCSSTG--SSAITCD-NTGKCNCLNNFAGK 614
            |||||:....|.:|::||.| ||    |...|.||||..||  :.::.|: :||:|.|.....|.
Human   813 GQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGL 877

  Fly   615 QCTLCTAGYY-----SYPDCLPCHCDSHGS-QGVSCNS-DGQCLCQPNFDGRQCDSCKEGFY--- 669
            :|..|....|     ::..|..|.|||.|: .|..|:. .|||||.||..||:|:.|:.|||   
Human   878 RCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISP 942

  Fly   670 -NFPSCEDCNCDPAGVIDKFAGCGSVPVGELCKCKE-RVTGRICNECKPLYWNLNISNTEGCEIC 732
             |...|..|:|...|.::..  |.|: .|: |.|:: .:.|:.|::||..|:..: ..|..|:.|
Human   943 GNATGCLPCSCHTTGAVNHI--CNSL-TGQ-CVCQDASIAGQRCDQCKDHYFGFD-PQTGRCQPC 1002

  Fly   733 DCWTDGTISALDTCTSKSGQCPCKPHTQGRRCQECRDGTFDLDSASLFGCKDCSCDVGGSWQSVC 797
            :|...|.::  :||...:|||.||....|.:|..|......||..:|.||...      .:|...
Human  1003 NCHLSGALN--ETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKT------PFQQPP 1059

  Fly   798 DKISGQCKCHPRITGLACTQPLTTHFFPTLHQFQYE-YEDGSLPSGTQVRYDY------DEAAFP 855
            .:  ||.:....| .|:.:.|.:    |..|...|. ..||.....|:.:|.|      |....|
Human  1060 PR--GQVQSSSAI-NLSWSPPDS----PNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLP 1117

  Fly   856 GFSSKGYVVFNAIQNDVRNEVNVFKSS----LYRIVLRYVNP-NAENVTATISVTSD--NPLEVD 913
            ......|:....:....|:....:|:.    ...:.|.|:.| .:::||.|.:..|:  .|:|  
Human  1118 YTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIE-- 1180

  Fly   914 QHVKVLLQPTSEPQFVTVAGPL----------GVKPSAIV--LDP-GRYVFTTKANKN----VML 961
                         :::....||          |.:.||.:  |.| .:|.|:.:|..:    ..|
Human  1181 -------------KYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSL 1232

  Fly   962 DYFV---------LLPAAYYEAGILTRHI--SNPCELGN--------MELCRHYKYASVE---VF 1004
            ...|         |.|....:......|:  |.|.||..        |...|..|..:.|   ||
Human  1233 PITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVF 1297

  Fly  1005 ------SPAATPFVIGENSKPTNPVETYTDPEHLQIVSHVGDIPVLSGSQNELHY---IVDVPRS 1060
                  ||.:  ||...|.....|.:|.|               .::|.:....|   ::.|..:
Human  1298 QSSGWLSPHS--FVESANENALKPPQTMT---------------TITGLEPYTKYEFRVLAVNMA 1345

  Fly  1061 GRYIFVIDYISDRN-------------FP-DSYYINLKLKDNPDSET--SVLLY----------- 1098
            |.....  ::|:|.             || .||.:|:..:...|:.|  .|:.|           
Human  1346 GSVSSA--WVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQ 1408

  Fly  1099 ---PCLYSTICRTSVNEDGMEKSFYINKEDLQP---------------VIISADIEDGS------ 1139
               |..:|.:..|:.::   |.|:.:  |.|:|               .:.||   .|:      
Human  1409 QSIPMAFSQLLHTAKSQ---ELSYTV--EGLKPYRIYEFTITLCNSVGCVTSA---SGAGQTLAA 1465

  Fly  1140 -----RFPI---ISVTAIPVDQWSIDYIN-PSPVCVIHDQQCATPKFRSVPDSKKIEFETDHEDR 1195
                 |.|:   |:.|.|.:..:..:.:| |||:..:..::.:.|...:.. .|.|.|..:...:
Human  1466 APAQLRPPLVKGINSTTIHLRWFPPEELNGPSPIYQLERRESSLPALMTTM-MKGIRFIGNGYCK 1529

  Fly  1196 IATNKPPYASLDERVKLVHLDSQNEATIVIESKVDATKPNLFVILVK------YYQPSHPKYQVY 1254
            ..::..|..:....:|........|..||..:. ...:...|.:.:|      .:.|.....:|.
Human  1530 FPSSTHPVNTDFTGIKASFRTKVPEGLIVFAAS-PGNQEEYFALQLKKGRLYFLFDPQGSPVEVT 1593

  Fly  1255 YTLTAGKNQYDGKFD----IQHCPSS--------SGCRGVIRPAGEGSFEIDDEF---------K 1298
            .|...||...|||:.    |:|....        :|...::    .||..|.|..         .
Human  1594 TTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAIL----NGSTVIGDNTGVFLGGLPRS 1654

  Fly  1299 FTITTDRSQSVWLDYLVVVP----LKQYNDDLLVEETFDQTKEFIQNCGHDHFHITHNASDFCKK 1359
            :||.....:.:...::..:.    :|.||...:.|....|:.|...|        .:|:.:.|..
Human  1655 YTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQIN--------VYNSWEGCPA 1711

  Fly  1360 SVFSLTADYNSGALPCNCDYAGSTSFECHPF---GG 1392
            |:       |.||     .:.|:...|.||:   ||
Human  1712 SL-------NEGA-----QFLGAGFLELHPYMFHGG 1735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LanANP_476617.1 LamNT 18..271 CDD:214532 57/264 (22%)
EGF_Lam 272..>314 CDD:238012 18/41 (44%)
EGF_Lam 332..389 CDD:238012 24/59 (41%)
EGF_Lam 402..443 CDD:238012 13/51 (25%)
EGF_Lam 448..491 CDD:238012 17/49 (35%)
Laminin_EGF 495..543 CDD:278482 15/49 (31%)
Laminin_EGF 541..589 CDD:278482 23/53 (43%)
Laminin_EGF 587..634 CDD:278482 16/54 (30%)
EGF_Lam 631..673 CDD:238012 22/47 (47%)
Laminin_EGF 677..729 CDD:278482 14/52 (27%)
Laminin_EGF 732..782 CDD:278482 16/49 (33%)
EGF_Lam 785..828 CDD:238012 7/42 (17%)
CBM6-CBM35-CBM36_like 831..966 CDD:271143 32/174 (18%)
Laminin_EGF 1375..1423 CDD:278482 6/21 (29%)
EGF_Lam 1420..1457 CDD:238012
Laminin_EGF 1466..1516 CDD:278482
Laminin_EGF 1514..1562 CDD:278482
LamB 1632..1760 CDD:214597
Laminin_EGF <1775..1801 CDD:278482
EGF_Lam 1808..1851 CDD:238012
EGF_Lam 1859..1907 CDD:214543
EGF_Lam 1916..1968 CDD:238012
EGF_Lam 1969..2015 CDD:238012
EGF_Lam 2016..>2054 CDD:238012
EGF_Lam 2063..>2097 CDD:238012
Laminin_I 2129..2385 CDD:283627
Tar 2278..2662 CDD:223910
Laminin_II 2566..2700 CDD:283628
LamG 2674..2843 CDD:238058
LamG 2878..3029 CDD:238058
LamG 3078..3205 CDD:214598
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
USH2ANP_996816.3 LamGL 146..283 CDD:214722
Laminin_N 291..516 CDD:413488 61/273 (22%)
EGF_Lam 517..565 CDD:238012 21/50 (42%)
EGF_Lam 574..639 CDD:238012 28/71 (39%)
Laminin_EGF 641..691 CDD:395007 12/52 (23%)
EGF_Lam 694..733 CDD:214543 16/39 (41%)
Laminin_EGF 747..795 CDD:395007 14/47 (30%)
EGF_Lam 794..844 CDD:238012 20/49 (41%)
EGF_Lam 847..897 CDD:214543 14/49 (29%)
EGF_Lam 900..948 CDD:238012 22/47 (47%)
EGF_Lam 950..1000 CDD:238012 14/54 (26%)
EGF_Lam 1001..>1037 CDD:238012 13/37 (35%)
fn3 1058..1132 CDD:394996 16/80 (20%)
fn3 1150..1227 CDD:394996 19/91 (21%)
FN3 1242..1357 CDD:238020 26/133 (20%)
FN3 1368..1451 CDD:214495 17/87 (20%)
LamG 1519..1678 CDD:238058 26/163 (16%)
LamG 1716..1868 CDD:238058 8/25 (32%)
FN3 1956..2051 CDD:238020
FN3 2241..2313 CDD:238020
FN3 2329..2428 CDD:238020
FN3 2432..2528 CDD:238020
FN3 2533..2619 CDD:238020
FN3 2621..2719 CDD:238020
FN3 2724..2799 CDD:238020
FN3 2818..2920 CDD:238020
FN3 2925..3015 CDD:238020
FN3 3026..>3087 CDD:238020
FN3 <3449..3494 CDD:238020
FN3 3503..3586 CDD:238020
FN3 3590..3676 CDD:238020
FN3 3680..3767 CDD:238020
fn3 3777..3856 CDD:394996
FN3 3866..3960 CDD:238020
FN3 3964..4057 CDD:238020
fn3 4161..4247 CDD:394996
FN3 4268..4351 CDD:238020
fn3 4357..4428 CDD:394996
FN3 4444..4516 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4518..4541
FN3 4529..4627 CDD:238020
FN3 4636..4730 CDD:238020
FN3 4826..4927 CDD:238020
PDZ-binding 5200..5202
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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