Protein Alignment LanA and ntn2

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: NP_001032492.2
• Gene: ntn2 / 641469
• ZFINID: ZDB-GENE-050310-2
• Length: 609
• Species: Danio rerio
• Alignment Length: 533
• Identity: 155/533 - (29%)
• Similarity: 234/533 - (43%)
• Gaps: 107/533 - (20%)

  Fly    26 PPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDYSVIQGQVCDYCDPTVPERNHPP 90
            |.:.|.|.|:::..::.||:.....   |.||    |.|  |...:  :.|..||.:.|...||.
Zfish    47 PEFINAAFGQEVSVSSVCGRPVSRS---CSLV----ERD--DRPAV--RTCQICDASDPRNAHPA 100

  Fly    91 E-----NAIDGTEAW----WQSPPLSRGMKFNEVNLTINFEQEFHVAYLFIRMGNSPRPGLWTLE 146
            .     |:......|    .||.||:       |.||::..::|.:.|:.::. .||||....:.
Zfish   101 SYLTDLNSAHNLTCWQSENLQSSPLN-------VTLTLSLGKKFEITYVSLQF-CSPRPESLAIY 157

  Fly   147 KSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITR--DDDVICTTEYSKIVPLENGEIPVMLLN 209
            ||.|||:||||:|.:|   :.|...:.:.....||:  :.:.:||..::.:.||..|.|....|:
Zfish   158 KSMDYGRTWTPYQFYS---SQCRRMYNRPNKAAITKQNEQEALCTDGHTDLYPLSGGLIAFSTLD 219

  Fly   210 ERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQD-----PTVTRRYFYSIKDISI 269
            .|||..::.:|.|||:|...|::|:...|.::.....||....:     |.....|:|::.|..:
Zfish   220 GRPSGKDFDSSPVLQDWVTVTDIRVVFSRPQHTRALPMSGRESEDALGAPGSLPTYYYAVGDFQV 284

  Fly   270 GGRCMCNGHADTC-DVKDPKSPVRILACRCQHHTCGIQCNECCPGFEQKKWRQNTNARPFNCEPC 333
            ||||.|||||..| ..||.|     |.|.|:|:|.|.:|:.|.|....:.|::.|......|.||
Zfish   285 GGRCKCNGHASRCVREKDGK-----LLCECKHNTEGPECDRCKPFHYDRPWQRATGKEANECLPC 344

  Fly   334 NCHGHSNECKYDEEVNRKGLSLDIHGHYDGGGVCQNCQHNTVGINCNKCKPKYYRPKGKHWNETD 398
            ||:.|:..|:::.|:.:      :.|. ..||||.||:|||.|.:|:.||..:||..||
Zfish   345 NCNLHARRCRFNMELYK------LSGR-KSGGVCMNCRHNTAGRHCHYCKEGFYRDMGK------ 396

  Fly   399 VCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSCDSCAYGYYGYPNCRECECNLNGTNGYHCEAE 463
                       :..|          |.|                  |:.|:|:..|..|..|...
Zfish   397 -----------AITH----------RRA------------------CKACDCHPVGAAGKTCNQT 422

  Fly   464 SGQQCPCKINFAGAYCKQCAEGYYGFPECKACECNKIGSITNDCNVTTGE--------CKCLTNF 520
            :| |||||....|..|.:||:||.. .......|.||..|.....::|.|        ||.|...
Zfish   423 TG-QCPCKDGVTGITCNRCAKGYQQ-SRSPVAPCIKIPVIKPTAVISTTEEPADCDSYCKPLKGN 485

  Fly   521 GGDNCER-CKHGY 532
            ...|.:: ||..|
Zfish   486 LKINMKKYCKKDY 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	71/260 (27%)
		EGF_Lam	272..>314	CDD:238012	20/42 (48%)
		EGF_Lam	332..389	CDD:238012	22/56 (39%)
		EGF_Lam	402..443	CDD:238012	3/40 (8%)
		Laminin_EGF	448..497	CDD:395007	17/48 (35%)
		Laminin_EGF	495..543	CDD:395007	13/47 (28%)
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:395007
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2134..2385	CDD:310534
		SMC_prok_B	2356..>2705	CDD:274008
		Laminin_II	2566..2700	CDD:368703
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
ntn2	NP_001032492.2	Laminin_N	45..286	CDD:459653	71/260 (27%)
		EGF_Lam	287..332	CDD:238012	21/49 (43%)
		EGF_Lam	343..393	CDD:238012	22/56 (39%)
		EGF_Lam	406..454	CDD:238012	17/49 (35%)
		NTR_netrin-1_like	490..606	CDD:239634	3/9 (33%)