DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LanA and NTN4

DIOPT Version :9

Sequence 1:	NP_476617.1	Gene:	LanA / 38723	FlyBaseID:	FBgn0002526	Length:	3712	Species:	Drosophila melanogaster
Sequence 2:	NP_067052.2	Gene:	NTN4 / 59277	HGNCID:	13658	Length:	628	Species:	Homo sapiens

Alignment Length:	660	Identity:	179/660 - (27%)
Similarity:	258/660 - (39%)	Gaps:	192/660 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GVASIGALLVILAISYCQAELTPPYFNLATGRKIYATATCGQDTDGPELYCKLVGANTEHDHIDY 68
            |||.:.        |.|:....|...|||.|||::|..||||  :..|||| ....||     |.
Human    22 GVAGVS--------SRCEKACNPRMGNLALGRKLWADTTCGQ--NATELYC-FYSENT-----DL 70

  Fly    69 SVIQGQVCDYCDPTVPERNHPPENAIDGT----EAWWQSPPLSRGMKFNEVNLTINFEQEFHVAY 129
            :..|.: ||.|:...|...|.|....|.:    ..||||     ....:...:.::.|.||:..:
Human    71 TCRQPK-CDKCNAAYPHLAHLPSAMADSSFRFPRTWWQS-----AEDVHREKIQLDLEAEFYFTH 129

  Fly   130 LFIRMGNSPRPGLWTLEKSTDYGKTWTPWQHFSDTPADCETYFGKDTYKPITRDDDV-----ICT 189
            |.: |..||||....|::|.|:||||.|:::|:   .:|...||        .:|||     |||
Human   130 LIV-MFKSPRPAAMVLDRSQDFGKTWKPYKYFA---TNCSATFG--------LEDDVVKKGAICT 182

  Fly   190 TEYSKIVPLENGEIPVMLLNERPSSTNYFNSTVLQEWTRATNVRIRLLRTKNLLGHLMSVARQDP 254
            ::||...|...||:....|:....:.|.:::.| ||..:.||:|::||:.::     ....|.|.
Human   183 SKYSSPFPCTGGEVIFKALSPPYDTENPYSAKV-QEQLKITNLRVQLLKRQS-----CPCQRNDL 241

  Fly   255 TVTRRYF--YSIKDISIGGRCMCNGHADTCDVKDPKSPVRILA--------CRCQHHTCGIQCNE 309
            ....::|  |:|.|..:.|.|.||||||.|.......||:...        |.|:|:|.|..|..
Human   242 NEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHMVHGKCMCKHNTAGSHCQH 306

  Fly   310 CCPGFEQKKWR--QNTNARPFNCEPCNCHGHSNECKYDEEV-----NRKGLSLDIHGHYDGGGVC 367
            |.|.:..:.|.  ......|..|..|.|:||::.|.:|..|     ||            .||||
Human   307 CAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVNVWEASGNR------------SGGVC 359

  Fly   368 QNCQHNTVGINCNKCKPKYYRPKGKHWNETDVCSPCQCDYFFSTGHCEEETGNCECRAAFQPPSC 432
            .:|||||.|..|.:|||.:||...:.::..|.|.||.|          ...|:....|
Human   360 DDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSC----------HPVGSAVLPA------- 407

  Fly   433 DSCAYGYYGYPNCRECECNLNGTNGYHCEAESGQQCPCKINFAGAYCKQCAEGYYGFPE--CKAC 495
            :|..:                      |:..:| .||||...||..|.:|..||:||.:  |:.|
Human   408 NSVTF----------------------CDPSNG-DCPCKPGVAGRRCDRCMVGYWGFGDYGCRPC 449

  Fly   496 ECNKIGSITNDCNVTTGECKCLTNFGGDNCERCKHGYFNYPTCSYCDCDNQGTESEICNKQSGQC 560
            :|      ...|:..||:|                      ..|:.|.|
Human   450 DC------AGSCDPITGDC----------------------ISSHTDID---------------- 470

  Fly   561 ICREGFGGPRCDQCLPGFYNYPDCKPCNCSS---------TGSSAITCDNTGKCNCLNNFAGKQC 616
                            .::..||.:|.:..|         .|.||:.  ::|||.|.....|...
Human   471 ----------------WYHEVPDFRPVHNKSEPAWEWEDAQGFSALL--HSGKCECKEQTLGNAK 517

  Fly   617 TLCTAGYYSY 626
            ..| ...|||
Human   518 AFC-GMKYSY 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532	81/263 (31%)
		EGF_Lam	272..>314	CDD:238012	18/49 (37%)
		EGF_Lam	332..389	CDD:238012	24/61 (39%)
		EGF_Lam	402..443	CDD:238012	6/40 (15%)
		EGF_Lam	448..491	CDD:238012	14/42 (33%)
		Laminin_EGF	495..543	CDD:278482	7/47 (15%)
		Laminin_EGF	541..589	CDD:278482	5/47 (11%)
		Laminin_EGF	587..634	CDD:278482	13/49 (27%)
		EGF_Lam	631..673	CDD:238012
		Laminin_EGF	677..729	CDD:278482
		Laminin_EGF	732..782	CDD:278482
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:278482
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:278482
		Laminin_EGF	1514..1562	CDD:278482
		LamB	1632..1760	CDD:214597
		Laminin_EGF	<1775..1801	CDD:278482
		EGF_Lam	1808..1851	CDD:238012
		EGF_Lam	1859..1907	CDD:214543
		EGF_Lam	1916..1968	CDD:238012
		EGF_Lam	1969..2015	CDD:238012
		EGF_Lam	2016..>2054	CDD:238012
		EGF_Lam	2063..>2097	CDD:238012
		Laminin_I	2129..2385	CDD:283627
		Tar	2278..2662	CDD:223910
		Laminin_II	2566..2700	CDD:283628
		LamG	2674..2843	CDD:238058
		LamG	2878..3029	CDD:238058
		LamG	3078..3205	CDD:214598
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
NTN4	NP_067052.2	Laminin_N	43..260	CDD:278484	75/248 (30%)
		EGF_Lam	261..320	CDD:238012	19/58 (33%)
		Laminin_EGF	332..392	CDD:278482	26/71 (37%)
		EGF_Lam	395..446	CDD:214543	19/90 (21%)
		NTR_netrin-4_like	516..626	CDD:239633	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910