Protein Alignment LanA and si:ch211-241e1.3

DIOPT Version :10

• Sequence 1: NP_476617.1
• Gene: LanA / 38723
• FlyBaseID: FBgn0002526
• Length: 3712
• Species: Drosophila melanogaster
• Sequence 2: XP_696031.7
• Gene: si:ch211-241e1.3 / 567640
• ZFINID: ZDB-GENE-030131-230
• Length: 1336
• Species: Danio rerio
• Alignment Length: 1612
• Identity: 357/1612 - (22%)
• Similarity: 601/1612 - (37%)
• Gaps: 478/1612 - (29%)

  Fly  1760 EDADGTGEYQFLAVERCSCPPGYSGH--------SCED---CAPGYYRDPSGPYGGYCIPCECNG 1813
            |:|:.....|....:|...|   |.|        :.||   |..|:|.|.||.: ..|:||.|||
Zfish    38 EEAEWIQRAQLNDAQRVQFP---SLHDTQQVQIPTLEDGQRCPAGHYLDRSGLF-PRCVPCSCNG 98

  Fly  1814 HSETCDCATGICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISE 1878
            ||..|:..||.|..|...|.|..||.|..|:|.:...   ..|..|.|||....||||..|  :|
Zfish    99 HSNECEENTGRCLNCADNTAGQRCELCKEGFYWSEAR---RKCTACPCPLGNQDNNFAVGC--TE 158

  Fly  1879 SGDQIHCECKPGYTGPRCESCANGFYGEPESIGQVCKPCECSGNINPEDQGSCDTRTGECLRCLN 1943
            :..:|.|.||.|:.|.|||.||:|:||:|...|..|:||.|:||:       ||::||.|
Zfish   159 TQSRIQCVCKTGHAGERCERCASGYYGDPLVYGGGCRPCRCAGNL-------CDSKTGAC----- 211

  Fly  1944 NTFGAACNLCAPGFYGDAIKLKNCQSCDCDDLGTQTCDPFVGVCTCHENVIGDRCDRCKPDHYGF 2008
                                 :|  |.:..|..|
Zfish   212 ---------------------RN--SLELQDTNT------------------------------- 222

  Fly  2009 ESGVGCRACDCGAASNSTQCDPHTGHCACKSGVTGRQCDRCAVDHWKYEKDGCTPCNCNQGYSRG 2073
                                                                             
Zfish   223 ----------------------------------------------------------------- 222

  Fly  2074 FGCNPNTGKCQCLPGVIGDRCDACPNRWVLIKDEGCQECNNCHHALLDVTDRMRYQIDSV--LED 2136
                                            :|.|:||:||...||:..:::..::..:  ..|
Zfish   223 --------------------------------EEQCEECDNCAQTLLNDLEKLEMELRRIKGQAD 255

  Fly  2137 FNSVTLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSKKANSELESDAKSYAKQVNQTLAN 2201
            |:|:.    .|.|. ...||.|.:.....|::..|..::.......:||.|..:.|..::....
Zfish   256 FDSLR----PSSKA-LLKQLEDAITATKNLVNTFSFAVNSQMPKIVQLEQDVINLADDMDSLKE- 314

  Fly  2202 AFDIRERSSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNLEAAASTKIDAALEQAQHILGQI 2266
              ::|:||..:        .:|:.:|:.:.:....::..::||    .|||...|:|...  .:.
Zfish   315 --EVRKRSGDS--------QKALANAENSHQRAKDLDTETQNL----LTKIRELLKQLMD--AKS 363

  Fly  2267 NGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALKNDIGEFSDHLEDLFNWSEASQAK 2331
            :|:|:......::|||:..:.:::..     ::.....:|.|.:..|.:..|||:.|     ..|
Zfish   364 DGSSLPSADLAKLLEKSENMVKDMEK-----RSFTTQKDAAKKEQAEANKFLEDVKN-----IVK 418

  Fly  2332 SADVERRNVANQKAFDN--SKFDT----VSEQKLQAEKNIKDAGNFLINGDLTLNQINQKLDNLR 2390
            ..|   :|....|..|.  |.::|    :.:...|||..:|.|.|        ||.:|.:  .|:
Zfish   419 QCD---QNEEASKRVDGLLSNYETKLKELEDLLKQAENMVKKAKN--------LNDVNAQ--GLK 470

  Fly  2391 DALNELNSFNKNVD---EELPVREDQHKEA----------------------------------- 2417
            |.|..:|...:..|   :::.:..||.|:.
Zfish   471 DILKRVNDLQRERDVVRDQIVLATDQLKDTQDLLKMFNDGKTEYEQLAAQLNGAKTDLKKKLQTV 535

  Fly  2418 ------DALTDQAEQKAA---ELAIKAQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLS 2473
                  :.|..|||:.|.   :||.:.|| |.|.....:..:.|:....||..|.:||.||::.:
Zfish   536 SQAAAKEKLVQQAEEHAENMYKLAKELQD-AVQNVSGRSGVQDALSGIEAYKNITDAVNAAEEAA 599

  Fly  2474 QDAISAAGNA-TDKTDG-IEERAHLADTGSTDLLQRAR---QSLQKVQDDLEPRLNASAGKVQKI 2533
            :.|..||..| .|.:.| :..||....|..::||:.|:   :.|:....||..:.|    ::|..
Zfish   600 KKAKEAADKALNDVSQGDLINRAQDLKTNGSNLLKTAKNTAKDLKGATKDLTEQKN----RLQDA 660

  Fly  2534 SAVNNATEHQL------------KDINKLIDQLPAESQRDMWKNSNANASDALEILKNVLEILEP 2586
            .....|.|.:|            .||.|:||     :.:.....:|.:.||.::.|.::...::.
Zfish   661 EKKKKALEEELLKIQDGLKGIQRDDIAKIID-----AAKKTAAAANRSTSDTMDQLNDIKAEVKK 720

  Fly  2587 VSVQTPKELEKAHGINRDLDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLG 2651
            :|: || .:.....:..::|:|.|:||          ||:..|.:..:::..|.    :....:.
Zfish   721 ISI-TP-TVSNMDNVLNNVDMTVKNVS----------GSIPSLLDKIDELNNQI----NYGNNVS 769

  Fly  2652 QEIENLKAQVEAARQLANSIKVGVNFKPSTILELKTPEKTKLLATRTNLSTYFRTTE--PSG--- 2711
            ..|..:|..:|.||..||.:.|.:.|.....:||:.|.....:...|.||...:..|  |:.
Zfish   770 DNINKIKELIEQARDAANRVVVPMKFTGVGHVELRPPADLADMRAFTALSLSLQRPEKPPARGDD 834

  Fly  2712 ----------FLLYLGNDNKTA-------QKN------------NDFVAVEIVNGYPILT----I 2743
                      |::|||..|.:.       :||            .|..|..|......|:    |
Zfish   835 AVVQQDEDDLFVMYLGKKNASGDYIGMVLRKNVLHFIYKLNGREYDIEAYNITESSSDLSFFDKI 899

  Fly  2744 DLGNGPERITSDKYVADGRWYQAVVDRMGPNAKLTIREELPNGDVVEHSKSGYLEGSQNILHVDK 2808
            ||    .||..|..|...:.|.: ::.|.|..|..      .||:           ::|:|.:..
Zfish   900 DL----YRIYQDAEVTYTKQYTS-INPMPPQTKEN------KGDL-----------TRNLLDLQP 942

  Fly  2809 NSRLF-VGGYPGISDFNAPPDLTTNSFSGDIEDLKIGDESVGLWNFVYG-DDNDQGARERDVLLE 2871
            :..:| |||||  .:|..|..|....:.|.||.....::.:.|:||... :.|.:...:|.:.|
Zfish   943 DDVVFYVGGYP--DNFTPPASLNYGKYKGCIEFSTFNEKFLSLYNFKNAVNINLETPCKRQIPL- 1004

  Fly  2872 KKKPVTGLRFKGNGYVQLNATSNLKSR--SSIQFSFKADKDTSNGLLFFYGRDKHYMSIEMIDGA 2934
              |......|:|:||.::     |..|  |::|...:.:....:.||.:.| ||        |..
Zfish  1005 --KSTESDYFEGSGYAKV-----LLERFPSNLQLVQRVETRAKDALLLYLG-DK--------DDD 1053

  Fly  2935 IFFNISLGEGGGVQSGSQDRYNDNQWHKVQAERENRNGLLK----VDDIVISRTN-------APL 2988
            .:::.|| |||.:....|::  |.....:   |.|...:|.    |..|:::|.|       ..:
Zfish  1054 FYYSASL-EGGYLVLRGQEK--DTILEPI---RSNEQPVLSPGIDVRLILVNRKNLRVIIGTTEV 1112

  Fly  2989 EADLELP-KLRRLYFGGHP----RRLNTSISLQPNFDGCIDNVVINQGVVDLTEYVTGGGVEEGC 3048
            :.|:.:| |....|.||.|    .|.|.::   |....|:.|::::.....:.|.|   |:..||
Zfish  1113 KRDVNIPRKFLYYYIGGIPSILRERYNITV---PALKACVKNILVSNVAPFIEEKV---GIGRGC 1171

  Fly  3049 SAKFSTVVSYAPHEYGF------LRMNNVSSDNNLHVVLHFKTTQPNGVLFYAANHDQSSTIGLS 3107
            |.:...|   ...|:|.      ||.:....|.||.  :.|::|:.:|:|.  .|...::.|.||
Zfish  1172 SDELLMV---RKAEFGSGSALEKLREDFKLDDVNLS--MGFRSTKSDGILM--ENQKNNNFIKLS 1229

  Fly  3108 LQDGLLKLNSMGSQLVIDDRILNDGEDHVVT-VQHTQG-ELRLTVDDVDNKRLGSPQPLILEGGD 3170
            |::|.:.| ..|..:....:...|||.|.:| |...|. |||:..:||..:..|
Zfish  1230 LENGFVVL-YFGGLIYTSTKQYQDGEWHYLTAVAKGQSVELRVDEEDVGQRLTG----------- 1282

  Fly  3171 IFFAGLPDNYRTPRNALASLAYFVGCISDVTVN--------EEIINFANSAE 3214
            ||......|....:|.      :.||:|::.:.        |::..:::|.:
Zfish  1283 IFREQYSSNVVLGKNT------YEGCVSNLYLRRPGSPYRAEDLSVYSSSGD 1328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LanA	NP_476617.1	LamNT	18..271	CDD:214532
		EGF_Lam	272..>314	CDD:238012
		EGF_Lam	332..389	CDD:238012
		EGF_Lam	402..443	CDD:238012
		Laminin_EGF	448..497	CDD:395007
		Laminin_EGF	495..543	CDD:395007
		Laminin_EGF	541..589	CDD:395007
		Laminin_EGF	587..634	CDD:395007
		Laminin_EGF	632..679	CDD:395007
		Laminin_EGF	677..729	CDD:395007
		Laminin_EGF	732..782	CDD:395007
		EGF_Lam	785..828	CDD:238012
		CBM6-CBM35-CBM36_like	831..966	CDD:271143
		Laminin_EGF	1375..1423	CDD:395007
		EGF_Lam	1420..1457	CDD:238012
		Laminin_EGF	1466..1516	CDD:395007
		Laminin_EGF	1514..1562	CDD:395007
		LamB	1632..1760	CDD:214597	357/1612 (22%)
		Laminin_EGF	<1775..1801	CDD:395007	11/36 (31%)
		EGF_Lam	1808..1851	CDD:238012	19/42 (45%)
		EGF_Lam	1859..1907	CDD:214543	24/47 (51%)
		EGF_Lam	1916..1968	CDD:238012	11/51 (22%)
		EGF_Lam	1969..2015	CDD:238012	3/45 (7%)
		EGF_Lam	2016..>2054	CDD:238012	0/37 (0%)
		EGF_Lam	2063..>2097	CDD:238012	0/33 (0%)
		Laminin_I	2134..2385	CDD:310534	54/256 (21%)
		SMC_prok_B	2356..>2705	CDD:274008	92/412 (22%)
		Laminin_II	2566..2700	CDD:368703	29/133 (22%)
		LamG	2674..2843	CDD:238058	47/207 (23%)
		LamG	2878..3029	CDD:238058	40/168 (24%)
		LamG	3078..3205	CDD:214598	32/136 (24%)
		LamG	3349..3512	CDD:238058
		LamG	3535..3689	CDD:238058
si:ch211-241e1.3	XP_696031.7	TNFRSF	<75..160	CDD:473981	37/90 (41%)
		EGF_Lam	93..>130	CDD:238012	18/36 (50%)
		Laminin_EGF	<164..194	CDD:395007	15/29 (52%)
		Laminin_I	261..509	CDD:310534	59/288 (20%)
		CwlO1	469..>658	CDD:443091	43/193 (22%)
		Laminin_II	701..818	CDD:368703	29/132 (22%)
		LamG	841..979	CDD:473984	38/161 (24%)
		LamG	1011..1154	CDD:238058	40/165 (24%)
		LamG	1183..1308	CDD:238058	38/146 (26%)